Drug & supplement interaction

Lactobacillus Jensenii + Varenicline

Varenicline brand names: Chantix, Champix, Tyrvaya.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lactobacillus Jensenii and Varenicline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Varenicline states a food rule worth keeping to.

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Interaction report

Lactobacillus Jensenii and Varenicline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Varenicline and Lactobacillus Jensenii in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lactobacillus Jensenii safety at a glance

Lactobacillus Jens... overall Use caution Generally considered low risk for healthy people, but supplement evidence is limited and quality varies.
Pregnancy Use caution Not well studied as a supplement in pregnancy; speak with your doctor before using.
Breastfeeding Use caution Little safety data exists for use while breastfeeding; check with your doctor first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Varenicline and Lactobacillus Jensenii? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Varenicline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Varenicline is filed under 3 classifications — including organic cation transporter 2 (oct2) substrates, oral drugs. Lactobacillus Jensenii has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Varenicline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lactobacillus Jensenii Does Interact With Other Medications

Lactobacillus Jensenii has 182 moderate known drug interactions in our database — Varenicline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Varenicline)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Jensenii

Covers the 2,830 medications we’ve checked against Lactobacillus Jensenii. Pick one to open its full report.

What to actually watch for

What Lactobacillus Jensenii Itself Has Been Linked To

This is not an interaction — nothing below involves Varenicline. It is the side-effect record for Lactobacillus Jensenii on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Lactobacillus Jensenii, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    “Since Lactobacillus jensenii preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. L. jensenii has been isolated in cases of bacteremia, sepsis, prostate abscess, perinephric abscess, endocarditis, and pulmonary septic emboli.”

    Lactobacillus Jensenii · Natural Medicines adverse-effect record, reported in sepsis.

    5 sources cited
    1. 107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
    2. 110917. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
    3. 110918. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
    4. 110920. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
    5. 110921. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.

Everything above comes from the Natural Medicines adverse-effect record for Lactobacillus Jensenii — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Varenicline’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Varenicline column appears here.

How to take them

Some Varenicline Products Have a Food Rule — Lactobacillus Jensenii Should Not Break It

At least one FDA label for a product containing Varenicline says to take it with food. If you take Lactobacillus Jensenii on an empty stomach out of habit, keep them separate — and take Varenicline with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Varenicline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Varenicline tablets should be taken orally after eating and with a full glass of water.

From the Dosage and Administration section of the FDA label we read for Varenicline — where that label names a specific product, the instruction is that product's. See the Varenicline drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Varenicline

This page covers Lactobacillus Jensenii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Varenicline page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (moderate), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 1 major · 10 moderate · 9 minor.

From our pharmacist’s overview on the Varenicline page

“For anyone taking varenicline (Chantix, Champix, Tyrvaya) to quit smoking, this list earns real caution rather than a quick skim. Activated charcoal is the single entry rated major; it binds many medicines in the gut and can pull varenicline's blood levels down, and losing that support mid-quit is a genuine setback.”

Reviewed by 2 · Jul 18, 2026

Open the Varenicline interaction page

How much people look this up

Where Lactobacillus Jensenii and Varenicline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Jensenii
Top half

#618 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Varenicline
Top half

#1,238 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactobacillus Jensenii reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lactobacillus Jensenii and Varenicline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lactobacillus Jensenii

What is Lactobacillus Jensenii?

  • Vaginal health
  • Maintaining healthy vaginal flora
  • Bacterial vaginosis support
  • Yeast infection support
  • General probiotic use

Lactobacillus jensenii is one of the natural 'good' bacteria found in a healthy vagina, and it is sometimes added to probiotic products marketed for vaginal health. While its role in the body is well recognized, there is only limited human research on taking it as a supplement, so the benefits are not proven. Talk with your pharmacist or doctor before using it, especially if you have a weakened immune system.

Lactobacillus jensenii · Lactobacillaceae · Whole live bacteria (probiotic strain) · Capsules, vaginal suppositories, multi-strain probiotic blends, powders

An interaction check asks whether these two react with each other — it does not ask whether Lactobacillus Jensenii is a good idea for someone in your situation. Here is what our Lactobacillus Jensenii record says about it on its own.

Lactobacillus Jensenii: dosing

There is no official or standardized dose for Lactobacillus jensenii. Probiotic amounts are often measured in colony-forming units (CFUs), and products vary widely.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Lactobacillus Jensenii monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lactobacillus Jensenii monograph & all interactions
Medication

About Varenicline

What Is Varenicline Used For?

Brand names: Chantix, Champix, Tyrvaya

Varenicline tablets — sold under brand names including Chantix — are used to help adults quit smoking. They work as part of a structured smoking cessation program.

Tyrvaya (varenicline solution) nasal spray is a separate product used to treat the signs and symptoms of dry eye disease. It is not used for smoking cessation.

Most-Reported Side Effects for Varenicline

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 14,514 reports
Depression 8,686 reports
Abnormal dreams 7,841 reports
Anxiety 5,978 reports
Insomnia 5,620 reports
See full Varenicline drug information
Keep checking

Other Drugs & Lactobacillus Jensenii

Browse every other medication we’ve checked against Lactobacillus Jensenii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Lactobacillus Jensenii page.

No interaction 2,647 drugs checked — show the list

We also checked Lactobacillus Jensenii against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Lactobacillus Jensenii list.

See the full Lactobacillus Jensenii interactions page
See every supplement checked against Varenicline, ranked by severity
Evidence & sources

Lactobacillus Jensenii References

The 6 references that drive our Lactobacillus Jensenii monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lactobacillus Jensenii and Varenicline Together: Common Questions

Is it safe to take Lactobacillus Jensenii with Varenicline?
We do not list a known interaction between Lactobacillus Jensenii and Varenicline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Lactobacillus Jensenii and Varenicline at the same time of day?
At least one FDA label for a product containing Varenicline says to take it with food. If you take Lactobacillus Jensenii on an empty stomach out of habit, keep them separate and take Varenicline with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Varenicline products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Lactobacillus Jensenii and Varenicline combination checked?
Interactions in our licensed database are recorded against drug classes. Varenicline is filed under 3 classifications, and Lactobacillus Jensenii has documented interactions with 1 drug class — none of Varenicline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lactobacillus Jensenii interact with any other medications?
Yes. Lactobacillus Jensenii has 182 documented drug interactions in our database — Varenicline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Varenicline interact with any supplements?
Yes. Varenicline has documented interactions with 20 supplements in our database — Lactobacillus Jensenii is not one of them. The Varenicline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lactobacillus Jensenii monograph Uses, safety profile, and every drug interaction in one place Varenicline drug information The full plain-English guide to this medication Varenicline supplement interactions Every supplement checked against Varenicline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Varenicline and Lactobacillus Jensenii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.