Drug & supplement interaction

Lathyrus + Atazanavir

Atazanavir brand name: Reyataz.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lathyrus and Atazanavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atazanavir states a food rule worth keeping to.

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Interaction report

Lathyrus and Atazanavir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atazanavir and Lathyrus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lathyrus at all — not against Atazanavir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lathyrus safety at a glance

Lathyrus overall Use caution Heavy or prolonged intake of grass pea is linked to a serious nerve disorder called lathyrism.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atazanavir and Lathyrus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Lathyrus Itself Has Been Linked To

This is not an interaction — nothing below involves Atazanavir. It is the side-effect record for Lathyrus on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Lathyrus, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Orally, consuming a diet high in lathyrus can cause neurotoxic manifestations including muscular rigidity, spasticity, weakness, paralysis, weak pulse, shallow breathing, convulsions, or death (6,58002,58008,58009,58012,58014,58018,58021,58023,58024). Consumption of lathyrus can also result in problems with collagen crosslinking.”

    Lathyrus · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 58002. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
    3. 58008. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. PubMed
    4. 58009. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
    5. 58012. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
    6. 58014. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed

    “When inhaled, lathyrus flour or pollen has caused allergic rhinoconjunctivitis and asthma in case reports.”

    Lathyrus · Natural Medicines adverse-effect record, reported in asthma.

    4 sources cited
    1. 58003. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. PubMed
    2. 58015. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
    3. 58019. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
    4. 58031. Lieberman, P. Preventing fatalities from anaphylaxis: an allergist-immunologist's perspective. Allergy Proc 1995;16(3):109-111. PubMed
  • Seizures Worth acting on Additional detail

    “Orally, lathyrus consumption is associated with the disease lathyrism. Neurological symptoms are known as neurolathyrism. Symptoms of neurolathyrism include muscular rigidity, spasticity, weakness, paralysis of leg muscles, weak pulse, shallow breathing, convulsions, or death (6).”

    Lathyrus · Natural Medicines adverse-effect record, reported in spasticity.

    6 sources cited
    1. 58002. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
    2. 58009. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
    3. 58012. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
    4. 58014. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed
    5. 58018. Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067. PubMed
    6. 58024. Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629.

Everything above comes from the Natural Medicines adverse-effect record for Lathyrus — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Atazanavir’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Atazanavir column appears here.

Special populations

Lathyrus in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Atazanavir Products Have a Food Rule — Lathyrus Should Not Break It

At least one FDA label for a product containing Atazanavir says to take it with food. If you take Lathyrus on an empty stomach out of habit, keep them separate — and take Atazanavir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atazanavir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

b For adult patients who cannot swallow the capsules, REYATAZ oral powder is taken once daily with food at the same recommended adult dosage as the capsules along with ritonavir.

From the Dosage and Administration section of the FDA label we read for Atazanavir — where that label names a specific product, the instruction is that product's. See the Atazanavir drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Atazanavir

This page covers Lathyrus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atazanavir page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 107 moderate · 42 minor.

From our pharmacist’s overview on the Atazanavir page

“Atazanavir (Reyataz) treats HIV, and keeping its blood level steady is what stands between viral control and drug resistance, so I read this list with genuine care. Of the 152 supplement and herbal ingredients on file, three carry a major rating: St.”

Reviewed by 2 · Jul 18, 2026

Open the Atazanavir interaction page

How much people look this up

Where Lathyrus and Atazanavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lathyrus
Steady interest

#754 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atazanavir
Top half

#725 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lathyrus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lathyrus and Atazanavir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lathyrus

What is Lathyrus?

  • Food and famine crop in some regions
  • Source of dietary protein
  • Traditional folk remedies
  • Animal fodder

Lathyrus most often refers to the grass pea (Lathyrus sativus), a hardy legume eaten as food in parts of Asia and Africa. While it is nutritious, heavy or prolonged consumption is linked to a serious neurological disorder called lathyrism, so it is not recommended as a dietary supplement. There is no good evidence supporting Lathyrus for any specific health condition.

Lathyrus sativus · Fabaceae · Seeds (grass pea / chickling pea); occasionally other plant parts · Dried seeds, flour, cooked legume dishes; not commonly sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether Lathyrus is a good idea for someone in your situation. Here is what our Lathyrus record says about it on its own.

Lathyrus: dosing

There is no established or standardized supplement dose for Lathyrus, and it is not recommended as a supplement. Because of the toxin it contains, larger and more frequent intake increases the risk of harm.If grass pea is part of your traditional diet, it is safest to eat it in moderation as one of many foods, and to prepare it by soaking and boiling. Do not rely on it as a main protein source.

From our Lathyrus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lathyrus monograph & all interactions
Medication

About Atazanavir

What Is Atazanavir Used For?

Brand name: Reyataz

Atazanavir capsules are used together with other antiretroviral medicines to treat HIV-1 infection in adults and in children 6 years and older who weigh at least 15 kg (about 33 lbs).

Reyataz — available as capsules and as an oral powder — is also approved for HIV-1 treatment in adults and in children as young as 3 months who weigh at least 5 kg (about 11 lbs). Reyataz oral powder must always be taken with ritonavir and food, and is not for use in children weighing less than 5 kg.

Most-Reported Side Effects for Atazanavir

From FAERS, the FDA’s public side-effect reporting system (14,470 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 1,318 reports
Foetal exposure during pregnancy 1,048 reports
Anxiety 878 reports
Emotional distress 660 reports
Anhedonia 601 reports
See full Atazanavir drug information
Keep checking

Other Drugs & Lathyrus

Browse every other medication we’ve checked against Lathyrus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lathyrus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lathyrus list.

See the full Lathyrus interactions page
See every supplement checked against Atazanavir, ranked by severity
Evidence & sources

Lathyrus References

The 22 references that drive our Lathyrus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
  3. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. PubMed
  4. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. PubMed
  5. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
  6. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
  7. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed
  8. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
  9. Haimanot, R. T., Kidane, Y., Wuhib, E., Kalissa, A., Alemu, T., Zein, Z. A., and Spencer, P. S. Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. Int J Epidemiol. 1990;19(3):664-672. PubMed
  10. Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067. PubMed
  11. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
  12. Ludolph, A. C., Hugon, J., Dwivedi, M. P., Schaumburg, H. H., and Spencer, P. S. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain 1987;110 ( Pt 1):149-165. PubMed
  13. Striefler, M., Cohn, D. F., Hirano, A., and Schujman, E. The central nervous system in a case of neurolathyrism. Neurology 1977;27(12):1176-1178.
  14. Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629.
  15. Cohn, D. F. and Streifler, M. Intoxication by the chickling pea (Lathyrus sativus): nervous system and skeletal findings. Arch.Toxicol.Suppl 1983;6:190-193. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lathyrus and Atazanavir Together: Common Questions

Is it safe to take Lathyrus with Atazanavir?
We do not list a known interaction between Lathyrus and Atazanavir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Lathyrus and Atazanavir at the same time of day?
At least one FDA label for a product containing Atazanavir says to take it with food. If you take Lathyrus on an empty stomach out of habit, keep them separate and take Atazanavir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atazanavir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Atazanavir interact with any supplements?
Yes. Atazanavir has documented interactions with 152 supplements in our database — Lathyrus is not one of them. The Atazanavir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lathyrus monograph Uses, safety profile, and every drug interaction in one place Atazanavir drug information The full plain-English guide to this medication Atazanavir supplement interactions Every supplement checked against Atazanavir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atazanavir and Lathyrus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.