Drug & supplement interaction

Laxogenin + Fluocinolone

Fluocinolone brand names: Synalar, Retisert.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Laxogenin and Fluocinolone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Laxogenin and Fluocinolone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fluocinolone and Laxogenin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Laxogenin at all — not against Fluocinolone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Laxogenin safety at a glance

Laxogenin overall Not established Human safety data are very limited and product quality varies widely.
Pregnancy Avoid No safety data exist, so avoid use during pregnancy.
Breastfeeding Avoid No safety data exist, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fluocinolone and Laxogenin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Fluocinolone’s Own FDA Label Lists

This is not an interaction — none of it involves Laxogenin. These are the most notable effects listed in the ADVERSE REACTIONS section of Fluocinolone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on
  • A higher chance of infection Worth acting on
  • Acne
  • Cough
  • Fever
  • Itching
  • Diarrhea
  • A skin rash
  • Vomiting
  • Headache

From the ADVERSE REACTIONS section of the FDA label for Fluocinolone. Read the label on DailyMed › Laxogenin’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Laxogenin side to compare — that is a limit of the record, not a statement that Laxogenin has no side effects.

Everything else you take

See Every Supplement That Interacts With Fluocinolone

This page covers Laxogenin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluocinolone page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Fluocinolone page

“All 17 supplements on file for fluocinolone (Synalar, Retisert) interact through the same doorway, absorption, and one of them warrants genuine caution. Activated charcoal, the lone major-rated entry, binds drugs in the digestive tract and can lower their levels even when the medicine wasn't swallowed, so it can undercut this steroid n…”

Reviewed by 2 · Jul 18, 2026

Open the Fluocinolone interaction page

One more smart check

Taking Laxogenin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Laxogenin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Laxogenin. Even though Laxogenin itself has no known interaction with Fluocinolone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Laxogenin and Fluocinolone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Laxogenin
Steady interest

#976 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluocinolone
Steady interest

#1,542 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Laxogenin is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Laxogenin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Laxogenin and Fluocinolone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Laxogenin

What is Laxogenin?

  • Muscle building and strength
  • Exercise recovery
  • Body recomposition / fat loss support
  • Athletic performance
  • Promoted as a 'natural anabolic'

Laxogenin is a plant-based steroid-like compound marketed mostly to bodybuilders for muscle growth and recovery, but there is very little human research to show it actually works. Because product quality and safety are not well studied, it is best to be cautious, and it should be avoided during pregnancy and breastfeeding.

Plant-derived steroidal sapogenin (often sourced from Smilax species or made semi-synthetically) · Capsules, tablets, liquid drops, powders, and combination 'natural anabolic' supplements

An interaction check asks whether these two react with each other — it does not ask whether Laxogenin is a good idea for someone in your situation. Here is what our Laxogenin record says about it on its own.

Laxogenin: dosing

There is no established or proven dose for laxogenin. Doses on product labels vary widely from brand to brand and are not backed by clinical research.If you choose to use it, follow the directions on the product label and do not exceed them. Choosing products that have been third-party tested (for example by NSF or USP) can help reduce the risk of contamination, though it does not prove the product works.

From our Laxogenin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Laxogenin monograph & all interactions
Medication

About Fluocinolone Topical

What Is Fluocinolone Topical Used For?

Brand names: Synalar, Retisert

Fluocinolone Acetonide Topical Oil, 0.01% is used on the skin to treat atopic dermatitis (eczema) in adults. It is also approved to treat moderate to severe atopic dermatitis in children 3 months of age and older, for up to 4 weeks.

It should not be used on the face, underarms, or groin unless a doctor specifically directs it, and should never be applied to the diaper area.

See full Fluocinolone Topical drug information
Keep checking

Other Drugs & Laxogenin

Browse every other medication we’ve checked against Laxogenin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Laxogenin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Laxogenin list.

See the full Laxogenin interactions page
See every supplement checked against Fluocinolone, ranked by severity
Evidence & sources

Laxogenin References

The 3 sources that drive our Laxogenin monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Laxogenin is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Laxogenin and Fluocinolone Together: Common Questions

Is it safe to take Laxogenin with Fluocinolone?
We do not list a known interaction between Laxogenin and Fluocinolone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Fluocinolone interact with any supplements?
Yes. Fluocinolone has documented interactions with 17 supplements in our database — Laxogenin is not one of them. The Fluocinolone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Laxogenin monograph Uses, safety profile, and every drug interaction in one place Fluocinolone Topical drug information The full plain-English guide to this medication Fluocinolone supplement interactions Every supplement checked against Fluocinolone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fluocinolone and Laxogenin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.