Drug & supplement interaction

Ligilactobacillus Salivarius + Cobicistat

Cobicistat brand name: Tybost.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Ligilactobacillus Salivarius and Cobicistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cobicistat states a food rule worth keeping to.

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Interaction report

Ligilactobacillus Salivarius and Cobicistat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cobicistat and Ligilactobacillus Salivarius in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ligilactobacillus Salivarius safety at a glance

Ligilactobacillus... overall Use caution Generally well tolerated in healthy people, but caution is advised for those who are seriously ill or immunocompromised.

Pregnancy Possibly Safe When used orally and appropriately. Ligilactobacillus salivarius has been safely used from about 30 weeks' gestation or diagnosis of gestational diabetes until... Read the full pregnancy detail

Breastfeeding Use caution Limited safety data while breastfeeding; check with your doctor first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cobicistat and Ligilactobacillus Salivarius? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Cobicistat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cobicistat is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, oral drugs. Ligilactobacillus Salivarius has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Cobicistat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ligilactobacillus Salivarius Does Interact With Other Medications

Ligilactobacillus Salivarius has 182 moderate known drug interactions in our database — Cobicistat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Cobicistat)

Taking anything else?

Check Another of Your Medications Against Ligilactobacillus Salivarius

Covers the 2,830 medications we’ve checked against Ligilactobacillus Salivarius. Pick one to open its full report.

What to actually watch for

What Ligilactobacillus Salivarius Itself Has Been Linked To

This is not an interaction — nothing below involves Cobicistat. It is the side-effect record for Ligilactobacillus Salivarius on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ligilactobacillus Salivarius, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

A higher chance of infection Worth acting on Additional detail
“Since Ligilactobacillus salivarius preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Some lactobacilli species have been isolated in cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis.”

Ligilactobacillus Salivarius · Natural Medicines adverse-effect record, reported in diabetes.
6 sources cited

107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

110917. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed

110918. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed

110920. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed

110921. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.

112546. Wang HK, Teng LJ, Chen YC, Du SH, Hsueh PR. Lactobacillus salivarius empyema with respiratory failure. J Microbiol Immunol Infect 2017;50(6):923-925. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ligilactobacillus Salivarius — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Cobicistat’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Cobicistat column appears here.

Special populations

Ligilactobacillus Salivarius in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately. Ligilactobacillus salivarius has been safely used from about 30 weeks' gestation or diagnosis of gestational diabetes until delivery.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cobicistat Products Have a Food Rule — Ligilactobacillus Salivarius Should Not Break It

At least one FDA label for a product containing Cobicistat says to take it with food. If you take Ligilactobacillus Salivarius on an empty stomach out of habit, keep them separate — and take Cobicistat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cobicistat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION TYBOST must be coadministered with atazanavir or darunavir at the same time, with food, and in combination with other HIV-1 antiretroviral agents.

From the Dosage and Administration section of the FDA label we read for Cobicistat — where that label names a specific product, the instruction is that product's. See the Cobicistat drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cobicistat

This page covers Ligilactobacillus Salivarius only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobicistat page lists 30 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Cannabidiol (cbd) (moderate), Cannabinol (cbn) (moderate) and Cannabis (moderate).

By severity: 1 major · 19 moderate · 10 minor.

From our pharmacist’s overview on the Cobicistat page

“Activated charcoal is the one entry to understand first if you take cobicistat (Tybost). Charcoal soaks up drugs in the gut, and since cobicistat's entire job is boosting an HIV medicine to protective levels, blunting its absorption can put the whole regimen at risk.”

Reviewed by 2 · Jul 18, 2026

Open the Cobicistat interaction page

How much people look this up

Where Ligilactobacillus Salivarius and Cobicistat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ligilactobacillus Salivarius

Steady interest

#1,238 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Cobicistat

Top half

#1,209 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ligilactobacillus Salivarius reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ligilactobacillus Salivarius and Cobicistat records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Ligilactobacillus Salivarius

What is Ligilactobacillus Salivarius?

Digestive and gut health
Oral and dental health
Immune support
Vaginal and urinary health
General probiotic supplementation

Ligilactobacillus salivarius (formerly called Lactobacillus salivarius) is a probiotic bacterium found naturally in the mouth and gut of humans and animals. People take it to support digestion, oral health, and immunity, but solid human evidence is still limited for most uses. It is generally well tolerated in healthy people, but those with weakened immune systems should check with a doctor first.

Ligilactobacillus salivarius · Lactobacillaceae · Live bacterial cells (probiotic strain) · Capsules, tablets, chewable tablets, powders, and some fortified foods or oral lozenges

An interaction check asks whether these two react with each other — it does not ask whether Ligilactobacillus Salivarius is a good idea for someone in your situation. Here is what our Ligilactobacillus Salivarius record says about it on its own.

Ligilactobacillus Salivarius: dosing

There is no official standardized dose for Ligilactobacillus salivarius. Probiotic doses are usually measured in colony-forming units (CFUs), and the amount varies widely between products.The best approach is to follow the directions on the product label, since doses are tied to the specific strain and formulation.

From our Ligilactobacillus Salivarius monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ligilactobacillus Salivarius monograph & all interactions

Medication

About Cobicistat

What Is Cobicistat Used For?

Brand name: Tybost

Tybost (cobicistat) is not itself an HIV treatment — it works by slowing the breakdown of certain HIV medicines so they stay active in your body long enough to work. Specifically, Tybost is used to boost the HIV medicines atazanavir or darunavir (once-daily dosing) as part of a complete HIV-1 treatment regimen in adults and in children weighing at least 14 kg (about 31 lbs).

Tybost is not interchangeable with ritonavir (another booster) for all HIV medicines. It is not recommended with darunavir twice-daily, fosamprenavir, saquinavir, or tipranavir.

Most-Reported Side Effects for Cobicistat

From FAERS, the FDA’s public side-effect reporting system (20,779 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Bone density decreased 8,112 reports

Chronic kidney disease 4,754 reports

Renal injury 4,577 reports

Tooth loss 4,186 reports

Bone loss 4,107 reports

See full Cobicistat drug information

Keep checking

Other Drugs & Ligilactobacillus Salivarius

Browse every other medication we’ve checked against Ligilactobacillus Salivarius — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

182Moderate

0Minor

2,647No known interaction

182 Moderate 2,647 No interaction

Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Ligilactobacillus Salivarius page.

No interaction 2,647 drugs checked — show the list

We also checked Ligilactobacillus Salivarius against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Ligilactobacillus Salivarius list.

See the full Ligilactobacillus Salivarius interactions page

See every supplement checked against Cobicistat, ranked by severity

Evidence & sources

Ligilactobacillus Salivarius References

The 10 references that drive our Ligilactobacillus Salivarius monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
Lindsay KL, Brennan L, Kennelly MA, et al. Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Am J Obstet Gynecol. 2015;212(4):496.e1-11. PubMed
Fernández L, Cárdenas N, Arroyo R, et al. Prevention of Infectious Mastitis by Oral Administration of Lactobacillus salivarius PS2 During Late Pregnancy. Clin Infect Dis. 2016;62(5):568-573.
Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
Wang HK, Teng LJ, Chen YC, Du SH, Hsueh PR. Lactobacillus salivarius empyema with respiratory failure. J Microbiol Immunol Infect 2017;50(6):923-925. PubMed
García Carretero R, Regodon Dominguez M, Ruiz Bastian M, Lopez Lomba M. Lactobacillus salivarius infection as a postoperative complication after bariatric surgery. Enferm Infecc Microbiol Clin (Engl Ed) 2018;36(1):60-61. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ligilactobacillus Salivarius and Cobicistat Together: Common Questions

Is it safe to take Ligilactobacillus Salivarius with Cobicistat?

We do not list a known interaction between Ligilactobacillus Salivarius and Cobicistat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Ligilactobacillus Salivarius and Cobicistat at the same time of day?

At least one FDA label for a product containing Cobicistat says to take it with food. If you take Ligilactobacillus Salivarius on an empty stomach out of habit, keep them separate and take Cobicistat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cobicistat products can differ — so check the directions on your own box. This is about absorption, not an interaction.

How was the Ligilactobacillus Salivarius and Cobicistat combination checked?

Interactions in our licensed database are recorded against drug classes. Cobicistat is filed under 2 classifications, and Ligilactobacillus Salivarius has documented interactions with 1 drug class — none of Cobicistat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Ligilactobacillus Salivarius interact with any other medications?

Yes. Ligilactobacillus Salivarius has 182 documented drug interactions in our database — Cobicistat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Cobicistat interact with any supplements?

Yes. Cobicistat has documented interactions with 30 supplements in our database — Ligilactobacillus Salivarius is not one of them. The Cobicistat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ligilactobacillus Salivarius monograph Uses, safety profile, and every drug interaction in one place Cobicistat drug information The full plain-English guide to this medication Cobicistat supplement interactions Every supplement checked against Cobicistat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cobicistat and Ligilactobacillus Salivarius?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.