Drug & supplement interaction

Lily-of-the-valley + Liotrix

Liotrix brand names: Euthroid 3, Euthroid 1/2, Euthroid 1.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Lily-of-the-valley and Liotrix in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Liotrix states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lily-of-the-valley and Liotrix

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Liotrix and Lily-of-the-valley in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lily-of-the-valley safety at a glance

Lily-of-the-valley overall Avoid All parts are poisonous and can cause life-threatening heart problems.

Pregnancy Likely Unsafe When used orally for self-medication. Avoid using. Read the full pregnancy detail

Breastfeeding Likely Unsafe When used orally for self-medication. Avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Liotrix and Lily-of-the-valley? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Liotrix

Interactions in our licensed database are recorded against drug classes, not just single drug names. Liotrix is filed under 2 classifications — thyroid hormone, oral drugs. Lily-of-the-valley has documented interactions with 8 drug classes — the most serious being corticosteroids (major), digoxin (lanoxin) (major) and quinine (major) — and none of Liotrix’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lily-of-the-valley Does Interact With Other Medications

Lily-of-the-valley has 26 major, 131 moderate known drug interactions in our database — Liotrix isn’t one of them. If you take anything else, check it against the full list below.

Major 26 Moderate 131 No known interaction 2,673 (incl. Liotrix)

Taking anything else?

Check Another of Your Medications Against Lily-of-the-valley

Covers the 2,830 medications we’ve checked against Lily-of-the-valley. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lily-of-the-valley and Liotrix May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Vomiting / Nausea Additional detail
Lily-of-the-valley
“Orally, lily-of-the-valley can cause nausea and vomiting (2).”

Lily-of-the-valley · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Liotrix

Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›
Headache Additional detail
Lily-of-the-valley
“Orally, lily-of-the-valley can cause headache and stupor (18). Visual color disturbances can also occur (18).”

Lily-of-the-valley · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Liotrix

Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›

Reported for Lily-of-the-valley but not commonly for Liotrix: raised blood pressure, an irregular heartbeat and a slow heartbeat.

Effects for Liotrix come from the ADVERSE REACTIONS section of its FDA label; effects for Lily-of-the-valley come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Lily-of-the-valley in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally for self-medication. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Liotrix Products Have a Food Rule — Lily-of-the-valley Should Not Break It

At least one FDA label for a product containing Liotrix says to take it on an empty stomach. Most supplements — Lily-of-the-valley included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Liotrix on its own and move Lily-of-the-valley to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Liotrix products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Liotrix

This page covers Lily-of-the-valley only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liotrix page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Liotrix page

“Liotrix (Euthroid) combines both thyroid hormones, and since steady hormone levels are the entire point of treatment, this list deserves a slow, serious read. Most entries fall into two camps: twenty-one ingredients act on the hormone itself, some boosting it and others blunting it, while another seventeen change how well the dose is a…”

Reviewed by 2 · Jul 18, 2026

Open the Liotrix interaction page

One more smart check

Taking Lily-of-the-valley as Part of a Dietary Supplement Product? Check It for Interactions

We hold 10 real supplement products containing Lily-of-the-valley, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lily-of-the-valley. Even though Lily-of-the-valley itself has no known interaction with Liotrix, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lily-of-the-valley and Liotrix Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lily-of-the-valley

Steady interest

#1,153 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Liotrix

Steady interest

#1,699 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lily-of-the-valley reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Lily-of-the-valley and Liotrix records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Lily-of-the-valley

What is Lily-of-the-valley?

Heart failure (historical)
Irregular heartbeat (historical)
Fluid retention/edema
General heart tonic (traditional)

Lily-of-the-valley is a poisonous plant that contains powerful heart-affecting compounds called cardiac glycosides, similar to the drug digoxin. While it was used historically for heart conditions, it is dangerous and is not recommended for self-treatment. All parts of the plant are toxic, and accidental poisoning can be life-threatening.

Convallaria majalis · Asparagaceae · Dried flowering tops, leaves, and roots · Tincture, dried herb extract, homeopathic preparations (rarely used today)

An interaction check asks whether these two react with each other — it does not ask whether Lily-of-the-valley is a good idea for someone in your situation. Here is what our Lily-of-the-valley record says about it on its own.

Lily-of-the-valley: dosing

There is no established safe dose of lily-of-the-valley for self-care, and it should not be used. Do not attempt to make or use any home preparation of this plant.

From our Lily-of-the-valley monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lily-of-the-valley monograph & all interactions

Medication

About Liotrix

What Is Liotrix Used For?

Brand names: Euthroid 3, Euthroid 1/2, Euthroid 1

Liotrix is used to treat hypothyroidism (a condition that results when the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyroidism include lack of energy, depression, constipation, weight gain, hair loss, dry skin, dry coarse hair, muscle cramps, decreased concentration, aches and pains, swelling of the legs, and increased sensitivity to cold. When taken correctly, liotrix can reverse these symptoms. Liotrix is also used to treat goiter (enlarged thyroid gland). This medication is also used to test for hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormone). Liotrix is in a class of medications called thyroid agents. It works by supplying the thyroid hormones normally produced by the body.

See full Liotrix drug information

Keep checking

Other Drugs & Lily-of-the-valley

Browse every other medication we’ve checked against Lily-of-the-valley — both the ones with a known interaction and the ones without. Select any drug for the full detail.

26Major

131Moderate

0Minor

2,672No known interaction

26 Major 131 Moderate 2,672 No interaction

Major

26 interactions

Moderate

131 interactions

Showing 60 of 131 moderate interactions — see all 131 on the Lily-of-the-valley page.

No interaction 2,672 drugs checked — show the list

We also checked Lily-of-the-valley against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,672 medications checked with no known interaction — see the full Lily-of-the-valley list.

See the full Lily-of-the-valley interactions page

See every supplement checked against Liotrix, ranked by severity

Evidence & sources

Lily-of-the-valley References

The 7 references that drive our Lily-of-the-valley monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Alexandre J, Foucault A, Coutance G, et al. Digitalis intoxication induced by an acute accidental poisoning by lily of the valley. Circulation 2012 Feb 28;125(8):1053-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lily-of-the-valley and Liotrix Together: Common Questions

Is it safe to take Lily-of-the-valley with Liotrix?

We do not list a known interaction between Lily-of-the-valley and Liotrix. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Lily-of-the-valley and Liotrix have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Lily-of-the-valley and Liotrix at the same time of day?

At least one FDA label for a product containing Liotrix says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Liotrix on its own and move Lily-of-the-valley to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Lily-of-the-valley and Liotrix combination checked?

Interactions in our licensed database are recorded against drug classes. Liotrix is filed under 2 classifications, and Lily-of-the-valley has documented interactions with 8 drug classes — none of Liotrix's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Lily-of-the-valley interact with any other medications?

Yes. Lily-of-the-valley has 157 documented drug interactions in our database — Liotrix is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Liotrix interact with any supplements?

Yes. Liotrix has documented interactions with 38 supplements in our database — Lily-of-the-valley is not one of them. The Liotrix interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lily-of-the-valley monograph Uses, safety profile, and every drug interaction in one place Liotrix drug information The full plain-English guide to this medication Liotrix supplement interactions Every supplement checked against Liotrix, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Liotrix and Lily-of-the-valley?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.