Drug & supplement interaction

Liver Extract + Metaxalone

Metaxalone brand name: Skelaxin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Liver Extract and Metaxalone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Liver Extract and Metaxalone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metaxalone and Liver Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Liver Extract safety at a glance

Liver Extract overall Use caution Generally low risk for healthy adults in food amounts, but it can deliver high levels of vitamin A and iron and carries source-quality concerns.
Pregnancy Use caution Liver products can contain very high vitamin A, which may harm a developing baby, so avoid unless advised by your doctor.
Breastfeeding Use caution Safety has not been well studied; check with your doctor before using.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metaxalone and Liver Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metaxalone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metaxalone is filed under 2 classifications — skeletal muscle relaxants, oral drugs. Liver Extract has documented interactions with 2 drug classes — the most serious being iron (minor) and warfarin (coumadin) (minor) — and none of Metaxalone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Liver Extract Does Interact With Other Medications

Liver Extract has 3 minor known drug interactions in our database — Metaxalone isn’t one of them. If you take anything else, check it against the full list below.

Minor 3 No known interaction 2,827 (incl. Metaxalone)
Taking anything else?

Check Another of Your Medications Against Liver Extract

Covers the 2,830 medications we’ve checked against Liver Extract. Pick one to open its full report.

What to actually watch for

What Metaxalone’s Own FDA Label Lists

This is not an interaction — none of it involves Liver Extract. These are the most notable effects listed in the ADVERSE REACTIONS section of Metaxalone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Serotonin syndrome Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on
  • An allergic reaction Worth acting on
  • Mood changes or irritability
  • Drowsiness
  • Anxiety or restlessness
  • Stomach upset
  • Itching

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Metaxalone. Read the label on DailyMed › Where a percentage is shown, it is the share of 3,328 voluntary FDA FAERS reports for Metaxalone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Liver Extract’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Liver Extract side to compare — that is a limit of the record, not a statement that Liver Extract has no side effects.

From our Q&A

Questions About Liver Extract or Metaxalone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Liver Extract or Metaxalone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metaxalone

This page covers Liver Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metaxalone page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Procaine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Metaxalone page

“Most of what interacts with metaxalone (Skelaxin), a muscle relaxant prescribed for painful muscle spasms, works by getting between the pill and your bloodstream. Fiber gums, mucilage herbs like slippery elm, and above all activated charcoal can bind or slow the drug in the gut, leaving you with less relief than your dose should deliver.”

Reviewed by 2 · Jul 18, 2026

Open the Metaxalone interaction page

One more smart check

Taking Liver Extract as Part of a Dietary Supplement Product? Check It for Interactions

We hold 595 real supplement products containing Liver Extract, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Liver Extract. Even though Liver Extract itself has no known interaction with Metaxalone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Liver Extract and Metaxalone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Liver Extract
Top 25%

#274 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metaxalone
Steady interest

#2,728 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Liver Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Liver Extract and Metaxalone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Liver Extract

What is Liver Extract?

  • Anemia and low iron
  • Vitamin B12 support
  • General energy and fatigue
  • Nutritional support for athletes
  • Liver health support

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before purified vitamins became available, but today there is little modern evidence that it offers benefits beyond what a balanced diet or standard supplements provide. Talk with your pharmacist or doctor before using it, especially if you are pregnant, have liver disease, or have iron overload conditions.

Liver tissue, usually from cattle (beef) or pork · Capsules, tablets, powders, desiccated (dried) liver supplements, and injectable forms (prescription/historical)

An interaction check asks whether these two react with each other — it does not ask whether Liver Extract is a good idea for someone in your situation. Here is what our Liver Extract record says about it on its own.

Liver Extract: dosing

There is no official, standardized dose of liver extract, and products vary widely in how concentrated they are. Different brands also contain different amounts of vitamin A, iron, and B12.The safest approach is to follow the dose on the product label and not exceed it. They can help you decide whether you actually need it and whether a standard, purified vitamin would be a safer, more reliable choice.

From our Liver Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Liver Extract monograph & all interactions
Medication

About Metaxalone

What Is Metaxalone Used For?

Brand name: Skelaxin

Metaxalone tablets are used to help relieve discomfort caused by acute (short-term), painful musculoskeletal conditions — things like muscle strains, sprains, and similar injuries. It is meant to be used together with rest, physical therapy, and other treatments, not as a stand-alone fix.

This use applies to adults and adolescents 13 years of age and older. Metaxalone tablets are available as the branded product Skelaxin and as a generic.

Most-Reported Side Effects for Metaxalone

From FAERS, the FDA’s public side-effect reporting system (3,328 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Completed suicide 261 reports
Nausea 198 reports
Fatigue 196 reports
Headache 172 reports
Toxicity to various agents 164 reports
See full Metaxalone drug information
Keep checking

Other Drugs & Liver Extract

Browse every other medication we’ve checked against Liver Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
3Minor
2,826No known interaction
3 Minor 2,826 No interaction
Minor

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Liver Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Liver Extract list.

See the full Liver Extract interactions page
See every supplement checked against Metaxalone, ranked by severity
Evidence & sources

Liver Extract References

The 4 references that drive our Liver Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Liver Extract and Metaxalone Together: Common Questions

Is it safe to take Liver Extract with Metaxalone?
We do not list a known interaction between Liver Extract and Metaxalone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Liver Extract and Metaxalone combination checked?
Interactions in our licensed database are recorded against drug classes. Metaxalone is filed under 2 classifications, and Liver Extract has documented interactions with 2 drug classes — none of Metaxalone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Liver Extract interact with any other medications?
Yes. Liver Extract has 3 documented drug interactions in our database — Metaxalone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metaxalone interact with any supplements?
Yes. Metaxalone has documented interactions with 20 supplements in our database — Liver Extract is not one of them. The Metaxalone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Liver Extract monograph Uses, safety profile, and every drug interaction in one place Metaxalone drug information The full plain-English guide to this medication Metaxalone supplement interactions Every supplement checked against Metaxalone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metaxalone and Liver Extract?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.