Lupin + Clemastine
Clemastine brand name: Tavist Allergy.
We found no known interaction between Lupin and Clemastine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Lupin and Clemastine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Clemastine and Lupin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Lupin at all — not against Clemastine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Lupin safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Lupin in Pregnancy & Breastfeeding
When processed lupin products (debittered lupin) are used in food amounts. Consuming commercially-prepared lupin products, including flour, bread, pasta, and breakfast cereals processed to contain less than 0.02% quinolizidine alkaloids, has not been associated with toxicity.
When bitter lupin products that contain toxic levels of quinolizidine alkaloids are used orally. These alkaloids have anticholinergic effects which can lead to respiratory failure and death. The quinolizidine alkaloid sparteine can also induce contractions of uterine smooth muscle.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Lupin or Clemastine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lupin or Clemastine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Benadryl With A Z-Pak (Azithromycin)? ›
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Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Clemastine
This page covers Lupin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clemastine page lists 72 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Alfalfa (moderate) and Angel's Trumpet (moderate).
By severity: 3 major · 57 moderate · 12 minor.
From our pharmacist’s overview on the Clemastine page
“Clemastine (Tavist Allergy) is an older, sedating antihistamine that already dries the mouth, blurs vision, and slows the gut, and that is exactly why this list earns real caution rather than a quick skim. Thirty of the 72 supplements on file pile the same drying, sedating anticholinergic load on top, and two of the three major-rated e…”
Reviewed by 2 · Jul 18, 2026
Taking Lupin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2 real supplement products containing Lupin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lupin. Even though Lupin itself has no known interaction with Clemastine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Lupin and Clemastine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,022 of 1,452 supplements looked up here in the last 7 days
#1,924 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lupin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lupin and Clemastine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Lupin
What is Lupin?
- Plant-based protein source
- Blood sugar support
- Cholesterol support
- Weight management
- Digestive fiber
Lupin is a protein- and fiber-rich legume that is eaten as food and sold as flour or protein powder. Early research suggests it may modestly help with blood sugar, cholesterol, and appetite, but evidence is limited. Its biggest concern is that it is a recognized food allergen and can cross-react in people allergic to peanuts.
Lupinus albus · Fabaceae · Seeds (beans) · Whole pickled beans, flour, protein powder, capsules
An interaction check asks whether these two react with each other — it does not ask whether Lupin is a good idea for someone in your situation. Here is what our Lupin record says about it on its own.
Lupin: dosing
There is no official or standardized supplement dose for lupin. As a food, people eat it in amounts similar to other beans or use lupin flour and protein powder as ingredients in recipes.If you use a lupin supplement or protein product, follow the directions on the product label, and start with a small amount to see how your body tolerates the fiber.
From our Lupin monograph — the full record covers uses, side effects and every documented interaction.
About Clemastine
What Is Clemastine Used For?
Brand name: Tavist Allergy
Clemastine treats symptoms of allergic rhinitis (hay fever and similar nasal allergies) — including sneezing, runny nose, itching, and watery eyes. The oral solution (Clemastine Fumarate syrup) is indicated for adults and children aged 6 through 12 years. The tablets (Clemastine Fumarate and Clemsza) are indicated for adults.
Clemastine also treats mild, uncomplicated allergic skin reactions — specifically urticaria (hives) and angioedema (swelling under the skin) — at the appropriate dosage level, in both the oral solution and tablet forms.
Other Drugs & Lupin
Browse every other medication we’ve checked against Lupin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Lupin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lupin list.
Lupin References
The 26 references that drive our Lupin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Bähr M, Fechner A, Kiehntopf M, Jahreis G. Consuming a mixed diet enriched with lupin protein beneficially affects plasma lipids in hypercholesterolemic subjects: a randomized controlled trial. Clin Nutr. 2015 Feb;34(1):7-14. PubMed
- Bähr M, Fechner A, Krämer J, Kiehntopf M, Jahreis G. Lupin protein positively affects plasma LDL cholesterol and LDL:HDL cholesterol ratio in hypercholesterolemic adults after four weeks of supplementation: a randomized, controlled crossover study. Nutr J PubMed
- Ballabio C, Peñas E, Uberti F, et al. Characterization of the sensitization profile to lupin in peanut-allergic children and assessment of cross-reactivity risk. Pediatr Allergy Immunol. 2013;24(3):270-5. PubMed
- Belski R, Mori TA, Puddey IB, et al. Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial. Int J Obes (Lond). 2011;35(6):810-9. PubMed
- Campbell CP, Jackson AS, Johnson AR, Thomas PS, Yates DH. Occupational sensitization to lupin in the workplace: occupational asthma, rhinitis, and work-aggravated asthma. J Allergy Clin Immunol. 2007;119(5):1133-9. PubMed
- Carvajal-Larenas FE, Linnemann AR, Nout MJ, Koziol M, van Boekel MA. Lupinus mutabilis: Composition, Uses, Toxicology, and Debittering. Crit Rev Food Sci Nutr. 2016;56(9):1454-87.
- Daverio M, Cavicchiolo ME, Grotto P, Lonati D, Cananzi M, Da Dalt L. Bitter lupine beans ingestion in a child: a disregarded cause of acute anticholinergic toxicity. Eur J Pediatr. 2014;173(12):1549-51. PubMed
- Di Grande A, Paradiso R, Amico S, Fulco G, Fantauzza B, Noto P. Anticholinergic toxicity associated with lupin seed ingestion: case report. Eur J Emerg Med. 2004;11(2):119-20. PubMed
- Eguíluz Gracia I, Martínez González de Lema B, Rubio-Pérez M, et al. Allergic reaction to undeclared lupin in a chocolate. J Investig Allergol Clin Immunol. 2015;25(2):140-2.
- Fechner A, Fenske K, Jahreis G. Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial. Nutr J. 2013;12:101. PubMed
- Fechner A, Kiehntopf M, Jahreis G. The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults. J Nutr. 2014;144(5):599-607. PubMed
- Gayraud J, Mairesse M, Fontaine JF, et al. The prevalence of sensitization to lupin flour in France and Belgium: a prospective study in 5,366 patients, by the Allergy Vigilance Network. Eur Ann Allergy Clin Immunol. 2009;41(1):17-22.
- Hieta N, Hasan T, Mäkinen-Kiljunen S, Lammintausta K. Lupin allergy and lupin sensitization among patients with suspected food allergy. Ann Allergy Asthma Immunol. 2009;103(3):233-7. PubMed
- Hodgson JM, Lee YP, Puddey IB, et al. Effects of increasing dietary protein and fibre intake with lupin on body weight and composition and blood lipids in overweight men and women. Int J Obes (Lond). 2010;34(6):1086-94. PubMed
- Lindvik H, Holden L, Løvik M, Cvancarova M, Halvorsen R. Lupin sensitization and clinical allergy in food allergic children in Norway. Acta Paediatr. 2008;97(1):91-5. PubMed
- Litkey J, Dailey MW. Anticholinergic toxicity associated with the ingestion of lupini beans. Am J Emerg Med. 2007;25(2):215-7. PubMed
- Moreno-Ancillo A, Gil-Adrados AC, Domínguez-Noche C, Cosmes PM. Lupine inhalation induced asthma in a child. Pediatr Allergy Immunol. 2005;16(6):542-4. PubMed
- Peeters KA, Koppelman SJ, Penninks AH, et al. Clinical relevance of sensitization to lupine in peanut-sensitized adults. Allergy. 2009;64(4):549-55. PubMed
- Pingault NM, Gibbs RA, Barclay AM, Monaghan M. Two cases of anticholinergic syndrome associated with consumption of bitter lupin flour. Med J Aust. 2009;191(3):173-4. PubMed
- Reis AM, Fernandes NP, Marques SL, et al. Lupine sensitisation in a population of 1,160 subjects. Allergol Immunopathol (Madr). 2007;35(4):162-3.
- Shaw J, Roberts G, Grimshaw K, White S, Hourihane J. Lupin allergy in peanut-allergic children and teenagers. Allergy. 2008;63(3):370-3.
- Zange J, Schopen K, Albracht K, et al. Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial. PLoS One. 2017;12(2):e01715 PubMed
- Ward NC, Mori TA, Beilin LJ, et al. The effect of regular consumption of lupin-containing foods on glycaemic control and blood pressure in people with type 2 diabetes mellitus. Food Funct. 2020;11(1):741-7. PubMed
- EFSA Panel on Contaminants in the Food Chain (CONTAM), Schrenk D, Bodin L, Chipman JK, et al. Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupi
- Frick KM, Kamphuis LG, Siddique KHM, Singh KB, Foley RC. Quinolizidine alkaloid biosynthesis in lupins and prospects for grain quality improvement. Front Plant Sci. 2017;8:87. doi: 10.3389/fpls.2017.00087. PubMed
- US Food and Drug Administration Consumer Updates. Allergies to a legume called lupin: what you need to know. 08/14/2015. https://www.fda.gov/consumers/consumer-updates/allergies-legume-called-lupin-what-you-need-know (Accessed 10/09/2020).
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Lupin and Clemastine Together: Common Questions
Is it safe to take Lupin with Clemastine?
Do Lupin and Clemastine have any of the same side effects?
Does Clemastine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.