Lysine + Metoclopramide Hydrochloride
Metoclopramide Hydrochloride brand name: Gimoti.
We found no known interaction between Lysine and Metoclopramide Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Lysine and Metoclopramide Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Metoclopramide Hydrochloride and Lysine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Lysine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Metoclopramide Hydrochloride
Interactions in our licensed database are recorded against drug classes, not just single drug names. Metoclopramide Hydrochloride is filed under 5 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 2d6 (cyp2d6) substrates. Lysine has documented interactions with 1 drug class — the most serious being 5-ht4 agonists (minor) — and none of Metoclopramide Hydrochloride’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Lysine Does Interact With Other Medications
Lysine has 1 minor known drug interaction in our database — Metoclopramide Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Lysine
We haven’t checked that one against Lysine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Lysine. Pick one to open its full report.
What Metoclopramide Hydrochloride Is Prescribed For, and What Lysine Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Metoclopramide Hydrochloride is a prescription medicine with approved uses on its FDA label. Lysine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Metoclopramide Hydrochloride is prescribed for: Gimoti (metoclopramide nasal spray) is approved for adults with acute and recurrent diabetic gastroparesis — a condition where diabetes damages the nerves controlling stomach emptying, causing nausea, vomiting, and bloating. It works to relieve those symptoms by helping the stomach empty more normally. Gimoti is not recommended for children, or for adults with moderate to severe kidney or liver disease. It is also not recommended for adults taking strong CYP2D6 inhibitor medications (certain antidepressants and other drugs that slow how the body breaks down metoclopramide).
Lysine has been studied for:
-
Diabetes studied, not established Lysine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Lysine for diabetes
It is unclear if oral lysine is beneficial in patients with diabetes.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Metoclopramide Hydrochloride on your own; if you are taking Lysine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Metoclopramide Hydrochloride
This page covers Lysine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoclopramide Hydrochloride page lists 135 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major), Kava (major) and L-tryptophan (major).
By severity: 7 major · 114 moderate · 14 minor.
From our pharmacist’s overview on the Metoclopramide Hydrochloride page
“Metoclopramide (Gimoti, also sold as Reglan) calms nausea and speeds a slow stomach by acting on the brain, and that is exactly where most of these 135 supplements and herbs collide with it. This is a list to treat with genuine care.”
Reviewed by 2 · Jul 18, 2026
Taking Lysine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 3,540 real supplement products containing Lysine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lysine. Even though Lysine itself has no known interaction with Metoclopramide Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Lysine and Metoclopramide Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#67 of 1,452 supplements looked up here in the last 7 days
#1,546 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lysine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Lysine and Metoclopramide Hydrochloride records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Lysine
What is Lysine?
- Cold sores (herpes labialis)
- Genital herpes outbreaks
- Supporting protein and collagen formation
- Calcium absorption support
- General nutritional supplement
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but the evidence is mixed and far from conclusive. For most healthy people who eat enough protein, supplements are likely unnecessary, but they are generally considered low-risk at typical doses.
Amino acid (L-lysine) · Tablets, capsules, powder, topical creams (often combined with other ingredients)
An interaction check asks whether these two react with each other — it does not ask whether Lysine is a good idea for someone in your situation. Here is what our Lysine record says about it on its own.
Lysine: dosing
There is no single official supplement dose of lysine for any health condition, and a truly standardized dose has not been established for uses like cold sores. Products vary widely in how much they contain.The best approach is to follow the directions on the product label and not exceed the recommended amount.
From our Lysine monograph — the full record covers uses, side effects and every documented interaction.
About Metoclopramide Nasal Spray
What Is Metoclopramide Nasal Spray Used For?
Brand name: Gimoti
Gimoti (metoclopramide nasal spray) is approved for adults with acute and recurrent diabetic gastroparesis — a condition where diabetes damages the nerves controlling stomach emptying, causing nausea, vomiting, and bloating. It works to relieve those symptoms by helping the stomach empty more normally.
Gimoti is not recommended for children, or for adults with moderate to severe kidney or liver disease. It is also not recommended for adults taking strong CYP2D6 inhibitor medications (certain antidepressants and other drugs that slow how the body breaks down metoclopramide).
Most-Reported Side Effects for Metoclopramide Hydrochloride
From FAERS, the FDA’s public side-effect reporting system (76,710 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Lysine
Browse every other medication we’ve checked against Lysine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Lysine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Bupropion ›
- Lisinopril ›
- Amoxicillin ›
- Bendamustine ›
- Acyclovir ›
- Amitriptyline ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Lysine list.
Lysine References
The 7 references that drive our Lysine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Lysine and Metoclopramide Hydrochloride Together: Common Questions
Is it safe to take Lysine with Metoclopramide Hydrochloride?
Do Lysine and Metoclopramide Hydrochloride have any of the same side effects?
Are Lysine and Metoclopramide Hydrochloride used for the same thing?
How was the Lysine and Metoclopramide Hydrochloride combination checked?
Does Lysine interact with any other medications?
Does Metoclopramide Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.