Macadamia Nut + Norgestrel
Norgestrel brand names: Ovrette, Orval 21.
We found no known interaction between Macadamia Nut and Norgestrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Macadamia Nut and Norgestrel
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Norgestrel and Macadamia Nut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Macadamia Nut at all — not against Norgestrel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Macadamia Nut safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Macadamia Nut in Pregnancy & Breastfeeding
When used as food.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Norgestrel
This page covers Macadamia Nut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Norgestrel page lists 188 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 140 moderate · 42 minor.
From our pharmacist’s overview on the Norgestrel page
“Norgestrel (Ovrette) is a progestin-only birth control pill, so the biggest danger on this page is not a strange side effect but a pill that quietly stops working. That risk makes this a page for genuine vigilance.”
Reviewed by 2 · Jul 18, 2026
Where Macadamia Nut and Norgestrel Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,104 of 1,452 supplements looked up here in the last 7 days
#1,819 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Macadamia Nut reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Macadamia Nut and Norgestrel records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Macadamia Nut
What is Macadamia Nut?
- Heart health
- Healthy snacking
- Weight management
- Skin and hair care (oil)
- Source of healthy fats
Macadamia nuts are a nutritious food rich in healthy monounsaturated fats, fiber, and minerals, and they can be a part of a heart-healthy diet. They are mainly eaten as a food rather than used as a medicine, and the strongest evidence supports them as a wholesome snack rather than a treatment for any disease. People with tree nut allergies should avoid them.
Macadamia integrifolia · Proteaceae · Nut (seed kernel) and nut oil · Whole nuts, nut butter, nut oil, milk, flour
An interaction check asks whether these two react with each other — it does not ask whether Macadamia Nut is a good idea for someone in your situation. Here is what our Macadamia Nut record says about it on its own.
Macadamia Nut: dosing
There is no official medicinal dose for macadamia nuts because they are a food, not a standardized supplement. A common snack portion is a small handful of nuts.If you use a macadamia product such as oil, butter, or a supplement, follow the directions on the product label.
From our Macadamia Nut monograph — the full record covers uses, side effects and every documented interaction.
About Progestin-Only (norethindrone) Oral Contraceptives
What Is Progestin-Only (norethindrone) Oral Contraceptives Used For?
Brand names: Ovrette, Orval 21
Norethindrone progestin-only pills — sometimes called the "mini-pill" — are used solely to prevent pregnancy. They do not contain estrogen, which makes them an option for women who cannot or prefer not to use estrogen-containing contraceptives.
When taken perfectly (same time every day, no missed pills), fewer than 1 in 100 women will become pregnant in the first year. With typical use, that number rises to about 9 in 100 — mostly because of late or skipped pills. Consistency is everything with this method.
Most-Reported Side Effects for Norgestrel
From FAERS, the FDA’s public side-effect reporting system (2,254 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Macadamia Nut
Browse every other medication we’ve checked against Macadamia Nut — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Macadamia Nut against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Clonazepam ›
- Quetiapine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Macadamia Nut list.
Macadamia Nut References
The 11 references that drive our Macadamia Nut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Garg ML, Blake RJ, Wills RB. Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J Nutr 2003;133:1060-3. PubMed
- Curb JD, Wergowske G, Dobbs JC, et al. Serum lipid effects of a high-monounsaturated fat diet based on macadamia nuts. Arch Intern Med 2000;160:1154-8. PubMed
- Lerch M, Egger C, Bircher AJ. Allergic reactions to macadamia nut. Allergy 2005;60:130-1. PubMed
- Pallares DE. Allergy to macadamia nut. Ann Allergy Asthma Immunol 2000;85:385-6. PubMed
- Teuber SS, Brown RL, Haapanen LA. Allergenicity of gourmet nut oils processed by different methods. J Allergy Clin Immunol 1997;99:502-7. PubMed
- Knight TE, Hausen BM. Dermatitis in a nutshell: occupational exposure to Macadamia integrifolia. J Am Acad Dermatol 1996;35:482-4. PubMed
- De Knop KJ, Hagendorens MM, Bridts CH, Stevens WJ, Ebo DG. Macadamia nut allergy: 2 case reports and a review of the literature. Acta Clin Belg. 2010;65(2):129-32.
- Randhawa I, Morphew T, Marsteller NL. Correlation of negative skin-prick test results for tree nuts and successful tree nut challenges among children with peanut allergy. Allergy Asthma Proc. 2018;39(6):456-460. PubMed
- Polk BI, Dinakarpandian D, Nanda M, Barnes C, Dinakar C. Association of tree nut and coconut sensitizations. Ann Allergy Asthma Immunol. 2016;117(4):412-416. PubMed
- Ekbote A, Hayman G, Bansal A. Macadamia nut allergy: potentially misleading specific IgE results. Allergy. 2010;65(10):1345. PubMed
- Herbst RA, Wahl R, Frosch PJ. Specific IgE reactivity and identification of potential allergens in macadamia allergy. J Eur Acad Dermatol Venereol. 2010;24(11):1361-3. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Norgestrel Is Linked to Lower Levels of 2 Nutrients
Natural Medicines records Norgestrel as a medicine that can lower these. This is not an interaction with Macadamia Nut — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Norgestrel nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Macadamia Nut and Norgestrel Together: Common Questions
Is it safe to take Macadamia Nut with Norgestrel?
Does Norgestrel interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.