Drug & supplement interaction

Mallow + Olopatadine Hydrochloride

Olopatadine Hydrochloride brand names: Pataday, Pazeo.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Mallow and Olopatadine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mallow and Olopatadine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Olopatadine Hydrochloride and Mallow in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mallow at all — not against Olopatadine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mallow safety at a glance

Mallow overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid unless cleared by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Olopatadine Hydrochloride and Mallow? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Mallow and Olopatadine Hydrochloride May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 2.8% of FDA reports for Olopatadine Hydrochloride Additional detail

    Mallow

    “Orally, mallow might cause nausea, vomiting, diarrhea, and acid regurgitation.”

    Mallow · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 95895. Ameri A, Heydarirad G, Rezaeizadeh H, Choopani R, Ghobadi A, Gachkar L. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. J Evid Based Complementary Altern Med. 2016;21(1):30-3. PubMed
    2. 95897. Elsagh M, Fartookzadeh MR, Kamalinejad M, et al. Efficacy of the Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial. Complement Ther Clin Pract. 2015;21(2):105-11. PubMed

    Olopatadine Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Olopatadine Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Mallow but not commonly for Olopatadine Hydrochloride: stomach upset, vomiting and diarrhea.

Effects for Olopatadine Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Mallow come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 10,462 voluntary FDA FAERS reports for Olopatadine Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Olopatadine Hydrochloride

This page covers Mallow only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Olopatadine Hydrochloride page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Olopatadine Hydrochloride page

“DMSO is the entry worth reading first for anyone using olopatadine (Pataday, Pazeo). Applied to the skin, DMSO can drive other topical medicines into the body faster and deeper, and since olopatadine is itself a topical antihistamine for itchy, allergic eyes, the concern is that combining the two nearby could amplify both what the drug…”

Reviewed by 2 · Jul 18, 2026

Open the Olopatadine Hydrochloride interaction page

One more smart check

Taking Mallow as Part of a Dietary Supplement Product? Check It for Interactions

We hold 83 real supplement products containing Mallow, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mallow. Even though Mallow itself has no known interaction with Olopatadine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mallow and Olopatadine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mallow
Top half

#540 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Olopatadine Hydrochloride
Steady interest

#2,178 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mallow reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mallow and Olopatadine Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mallow

What is Mallow?

  • Sore throat and cough
  • Digestive upset
  • Skin irritation
  • Mild constipation
  • Mouth and gum irritation

Mallow (Malva sylvestris) is a traditional herb valued for its soothing, mucilage-rich leaves and flowers, used mostly for sore throat, cough, and minor skin or stomach irritation. Scientific evidence in humans is limited, so it should be seen as a gentle traditional remedy rather than a proven treatment. It is generally considered low-risk for short-term use, but pregnant and breastfeeding people should avoid it due to a lack of safety data.

Malva sylvestris · Malvaceae · Leaves and flowers (sometimes roots) · Tea, dried herb, capsules, liquid extracts, topical preparations, gargles

An interaction check asks whether these two react with each other — it does not ask whether Mallow is a good idea for someone in your situation. Here is what our Mallow record says about it on its own.

Mallow: dosing

There is no standardized, well-established dose for mallow. Traditional use often involves a tea made from a small amount of dried leaves or flowers steeped in hot water.Because products vary widely in strength and form (tea, capsule, or liquid extract), the best approach is to follow the directions on the product label.

From our Mallow monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mallow monograph & all interactions
Medication

About Olopatadine Ophthalmic

What Is Olopatadine Ophthalmic Used For?

Brand names: Pataday, Pazeo

Olopatadine hydrochloride ophthalmic solution is used to treat eye itching caused by allergic conjunctivitis — an allergic reaction that makes your eyes red, itchy, and uncomfortable. It works as both an antihistamine and a mast cell stabilizer to calm that allergic response right at the eye.

See full Olopatadine Ophthalmic drug information
Keep checking

Other Drugs & Mallow

Browse every other medication we’ve checked against Mallow — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Mallow References

The 2 references that drive our Mallow monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ameri A, Heydarirad G, Rezaeizadeh H, Choopani R, Ghobadi A, Gachkar L. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. J Evid Based Complementary Altern Med. 2016;21(1):30-3. PubMed
  2. Elsagh M, Fartookzadeh MR, Kamalinejad M, et al. Efficacy of the Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial. Complement Ther Clin Pract. 2015;21(2):105-11. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mallow and Olopatadine Hydrochloride Together: Common Questions

Is it safe to take Mallow with Olopatadine Hydrochloride?
We do not list a known interaction between Mallow and Olopatadine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mallow and Olopatadine Hydrochloride have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Olopatadine Hydrochloride interact with any supplements?
Yes. Olopatadine Hydrochloride has documented interactions with 3 supplements in our database — Mallow is not one of them. The Olopatadine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Olopatadine Hydrochloride and Mallow?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.