Drug & supplement interaction

Mallow + Primaquine Phosphate

Primaquine Phosphate brand name: Primaquine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mallow and Primaquine Phosphate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mallow and Primaquine Phosphate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Primaquine Phosphate and Mallow in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mallow at all — not against Primaquine Phosphate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mallow safety at a glance

Mallow overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid unless cleared by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Primaquine Phosphate and Mallow? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Mallow and Primaquine Phosphate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting / Nausea Additional detail

    Mallow

    “Orally, mallow might cause nausea, vomiting, diarrhea, and acid regurgitation.”

    Mallow · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 95895. Ameri A, Heydarirad G, Rezaeizadeh H, Choopani R, Ghobadi A, Gachkar L. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. J Evid Based Complementary Altern Med. 2016;21(1):30-3. PubMed
    2. 95897. Elsagh M, Fartookzadeh MR, Kamalinejad M, et al. Efficacy of the Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial. Complement Ther Clin Pract. 2015;21(2):105-11. PubMed

    Primaquine Phosphate

    Listed in the ADVERSE REACTIONS section of the FDA label for Primaquine Phosphate. Read the label on DailyMed ›

Reported for Mallow but not commonly for Primaquine Phosphate: stomach upset and diarrhea.

Effects for Primaquine Phosphate come from the ADVERSE REACTIONS section of its FDA label; effects for Mallow come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 81 voluntary FDA FAERS reports for Primaquine Phosphate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Primaquine Phosphate

This page covers Mallow only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Primaquine Phosphate page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Grapefruit (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Primaquine Phosphate page

“Activated charcoal, the only major-rated interaction among the 18 on file, can bind primaquine phosphate (Primaquine) in the gut and shrink how much of each dose your body actually absorbs. That matters more than usual, because this antimalarial exists to wipe out the malaria parasites hiding in the liver, and an under-absorbed course…”

Reviewed by 2 · Jul 18, 2026

Open the Primaquine Phosphate interaction page

One more smart check

Taking Mallow as Part of a Dietary Supplement Product? Check It for Interactions

We hold 83 real supplement products containing Mallow, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mallow. Even though Mallow itself has no known interaction with Primaquine Phosphate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mallow and Primaquine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mallow
Top half

#574 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Primaquine Phosphate
Steady interest

#1,851 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mallow reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mallow and Primaquine Phosphate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mallow

What is Mallow?

  • Sore throat and cough
  • Digestive upset
  • Skin irritation
  • Mild constipation
  • Mouth and gum irritation

Mallow (Malva sylvestris) is a traditional herb valued for its soothing, mucilage-rich leaves and flowers, used mostly for sore throat, cough, and minor skin or stomach irritation. Scientific evidence in humans is limited, so it should be seen as a gentle traditional remedy rather than a proven treatment. It is generally considered low-risk for short-term use, but pregnant and breastfeeding people should avoid it due to a lack of safety data.

Malva sylvestris · Malvaceae · Leaves and flowers (sometimes roots) · Tea, dried herb, capsules, liquid extracts, topical preparations, gargles

An interaction check asks whether these two react with each other — it does not ask whether Mallow is a good idea for someone in your situation. Here is what our Mallow record says about it on its own.

Mallow: dosing

There is no standardized, well-established dose for mallow. Traditional use often involves a tea made from a small amount of dried leaves or flowers steeped in hot water.Because products vary widely in strength and form (tea, capsule, or liquid extract), the best approach is to follow the directions on the product label.

From our Mallow monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mallow monograph & all interactions
Medication

About Primaquine

What Is Primaquine Used For?

Brand name: Primaquine

Primaquine Phosphate Tablets are indicated for the radical cure of vivax malaria — specifically, to prevent relapse by eliminating the dormant liver forms (hypnozoites) of Plasmodium vivax that survive after the initial infection is treated.

It is also used after a course of chloroquine phosphate in people who have had vivax malaria or who are completing malaria-suppression therapy in an area where vivax malaria is common.

See full Primaquine drug information
Keep checking

Other Drugs & Mallow

Browse every other medication we’ve checked against Mallow — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mallow against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mallow list.

See the full Mallow interactions page
See every supplement checked against Primaquine Phosphate, ranked by severity
Evidence & sources

Mallow References

The 2 references that drive our Mallow monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ameri A, Heydarirad G, Rezaeizadeh H, Choopani R, Ghobadi A, Gachkar L. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. J Evid Based Complementary Altern Med. 2016;21(1):30-3. PubMed
  2. Elsagh M, Fartookzadeh MR, Kamalinejad M, et al. Efficacy of the Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial. Complement Ther Clin Pract. 2015;21(2):105-11. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mallow and Primaquine Phosphate Together: Common Questions

Is it safe to take Mallow with Primaquine Phosphate?
We do not list a known interaction between Mallow and Primaquine Phosphate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mallow and Primaquine Phosphate have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Primaquine Phosphate interact with any supplements?
Yes. Primaquine Phosphate has documented interactions with 18 supplements in our database — Mallow is not one of them. The Primaquine Phosphate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mallow monograph Uses, safety profile, and every drug interaction in one place Primaquine drug information The full plain-English guide to this medication Primaquine Phosphate supplement interactions Every supplement checked against Primaquine Phosphate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Primaquine Phosphate and Mallow?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.