Drug & supplement interaction

Manaca + Losartan Potassium

Losartan Potassium brand name: Cozaar.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Manaca and Losartan Potassium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Manaca and Losartan Potassium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Losartan Potassium and Manaca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Manaca at all — not against Losartan Potassium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manaca safety at a glance

Manaca overall Use caution It belongs to the potentially toxic nightshade family and lacks safety testing in humans.
Pregnancy Avoid Not enough safety data and possible toxicity make it unsafe to use during pregnancy.
Breastfeeding Avoid No reliable safety information exists, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Losartan Potassium and Manaca? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Losartan Potassium’s Own FDA Label Lists

This is not an interaction — none of it involves Manaca. These are the most notable effects listed in the ADVERSE REACTIONS section of Losartan Potassium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on
  • Muscle weakness Worth acting on
  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Low blood sugar Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Shortness of breath Worth acting on mentioned in 5.2% of FDA reports for Losartan Potassium
  • Chest pain Worth acting on
  • Low mood Worth acting on

Showing the 10 most notable of 44 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Losartan Potassium. Read the label on DailyMed › Where a percentage is shown, it is the share of 89,498 voluntary FDA FAERS reports for Losartan Potassium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Manaca’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Manaca side to compare — that is a limit of the record, not a statement that Manaca has no side effects.

From our Q&A

Questions About Manaca or Losartan Potassium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Manaca or Losartan Potassium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Losartan Potassium

This page covers Manaca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Losartan Potassium page lists 253 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and St. John's Wort (major).

By severity: 6 major · 205 moderate · 42 minor.

From our pharmacist’s overview on the Losartan Potassium page

“Losartan potassium (Cozaar) treats high blood pressure, and this is a list to respect, because six of its 253 supplement interactions carry a major rating. Most entries do one of two things.”

Reviewed by 2 · Jul 18, 2026

Open the Losartan Potassium interaction page

How much people look this up

Where Manaca and Losartan Potassium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manaca
Steady interest

#872 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Losartan Potassium
Top 10

#6 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Manaca is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manaca reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Manaca and Losartan Potassium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Manaca

What is Manaca?

  • Joint pain and arthritis
  • Rheumatism
  • Skin conditions
  • As a diuretic
  • Inflammation

Manaca (Brunfelsia uniflora) is a South American shrub traditionally used for arthritis, rheumatism, and skin problems. There is very little reliable human research to support these uses, and the plant belongs to the nightshade family and may be toxic, so caution is strongly advised. Talk to a pharmacist or doctor before using it.

Brunfelsia uniflora · Solanaceae · Roots and bark; sometimes leaves · Tincture, dried root, capsules, tea, homeopathic preparations

An interaction check asks whether these two react with each other — it does not ask whether Manaca is a good idea for someone in your situation. Here is what our Manaca record says about it on its own.

Manaca: dosing

There is no established or standardized dose for manaca. Because the plant may be toxic and has not been tested in proper human studies, safe dosing has not been determined.If you choose to use a product that contains manaca, follow the directions on the label and do not exceed them.

From our Manaca monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manaca monograph & all interactions
Medication

About Losartan

What Is Losartan Used For?

Brand name: Cozaar

Losartan tablets — available as branded Cozaar and several generic products — are used to treat high blood pressure (hypertension) in adults and children 6 years and older. Lowering blood pressure reduces the risk of strokes and heart attacks. Losartan tablets are also used to reduce the risk of stroke in people with high blood pressure who also have left ventricular hypertrophy (an enlarged left side of the heart). Note: evidence suggests this stroke-risk benefit may not apply to Black patients.

Losartan tablets are additionally approved to protect the kidneys in people with type 2 diabetes, high blood pressure, and signs of kidney damage (diabetic nephropathy). Arbli, the oral suspension form, shares these same approved uses.

Most-Reported Side Effects for Losartan Potassium

From FAERS, the FDA’s public side-effect reporting system (89,498 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 6,464 reports
Nausea 5,301 reports
Diarrhea 5,184 reports
Dyspnea 4,689 reports
Dizziness 4,429 reports
See full Losartan drug information
Keep checking

Other Drugs & Manaca

Browse every other medication we’ve checked against Manaca — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Manaca against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Manaca list.

See the full Manaca interactions page
See every supplement checked against Losartan Potassium, ranked by severity
Evidence & sources

Manaca References

The 1 sources that drive our Manaca monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Manaca is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Safely — NIH MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manaca and Losartan Potassium Together: Common Questions

Is it safe to take Manaca with Losartan Potassium?
We do not list a known interaction between Manaca and Losartan Potassium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Losartan Potassium interact with any supplements?
Yes. Losartan Potassium has documented interactions with 253 supplements in our database — Manaca is not one of them. The Losartan Potassium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manaca monograph Uses, safety profile, and every drug interaction in one place Losartan drug information The full plain-English guide to this medication Losartan Potassium supplement interactions Every supplement checked against Losartan Potassium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Losartan Potassium and Manaca?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.