Drug & supplement interaction

Mercury Herb + Tramadol

Tramadol brand names: Ultram, Zytram XL, Qdolo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mercury Herb and Tramadol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mercury Herb and Tramadol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tramadol and Mercury Herb in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mercury Herb at all — not against Tramadol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mercury Herb safety at a glance

Mercury Herb overall Avoid The plant is considered potentially toxic and has poorly defined safe doses.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tramadol and Mercury Herb? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Mercury Herb and Tramadol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Mercury Herb

    “Orally, mercury herb might cause diarrhea and overactive bladder (18). Symptoms of poisoning might include nerve paralysis, liver and kidney failure, and death (18). The pollen has shown to be allergenic, and may be responsible for rhinitis and asthmatic symptoms.”

    Mercury Herb · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 4143. Vallverdu A, Garcia-Ortega P, Martinez J, et al. Mercurialis annua: characterization of main allergens and cross- reactivity with other species. Int Arch Allergy Immunol 1997;112:356-64. PubMed
    3. 4144. Garcia-Ortega P, Martinez J, Martinez A, et al. Mercurialis annua pollen: a new source of allergic sensitization and respiratory disease. J Allergy Clin Immunol 1992;89:987-93.

    Tramadol

    Listed in the ADVERSE REACTIONS section of the FDA label for Tramadol. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Mercury Herb

    “Orally, mercury herb might cause diarrhea (18).”

    Mercury Herb · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Tramadol

    Listed in the ADVERSE REACTIONS section of the FDA label for Tramadol. Read the label on DailyMed ›

Reported for Mercury Herb but not commonly for Tramadol: kidney problems and a stuffy or runny nose.

Effects for Tramadol come from the ADVERSE REACTIONS section of its FDA label; effects for Mercury Herb come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Mercury Herb in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Mercury Herb or Tramadol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mercury Herb or Tramadol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tramadol

This page covers Mercury Herb only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tramadol page lists 223 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 10 major · 174 moderate · 39 minor.

From our pharmacist’s overview on the Tramadol page

“Tramadol (Ultram, Qdolo) is an opioid, and its supplement interactions worry me more than most because the worst of them compound the drug's most dangerous effects. Alcohol and dozens of calming herbs deepen its sedation, sometimes to the point of slowed breathing.”

Reviewed by 2 · Jul 18, 2026

Open the Tramadol interaction page

How much people look this up

Where Mercury Herb and Tramadol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mercury Herb
Steady interest

#1,327 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tramadol
Top half

#1,029 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mercury Herb reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mercury Herb and Tramadol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mercury Herb

What is Mercury Herb?

  • Constipation
  • Mild skin irritation
  • Swelling or inflammation (topical)
  • Traditional folk remedy

Mercury Herb (Mercurialis annua) is a traditional European plant once used as a mild laxative and topical remedy, but it has very little modern scientific support and is considered potentially toxic. Because the plant can cause serious poisoning when misused, most herbal experts no longer recommend it, and you should talk to a pharmacist or doctor before considering it.

Mercurialis annua · Euphorbiaceae · Leaves and aerial (above-ground) parts · Dried herb, tea/infusion, poultice, traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Mercury Herb is a good idea for someone in your situation. Here is what our Mercury Herb record says about it on its own.

Mercury Herb: dosing

There is no established or standardized safe dose for Mercury Herb. Because of its toxicity concerns and the lack of modern research, no reliable amount can be recommended.We do not provide specific dosing for this plant. In most cases, safer and better-studied options are available for constipation and skin concerns.

From our Mercury Herb monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mercury Herb monograph & all interactions
Medication

About Tramadol

What Is Tramadol Used For?

Brand names: Ultram, Zytram XL, Qdolo

Tramadol is used in adults for pain that is severe enough to need an opioid-strength medication and where non-opioid treatments haven't been enough. It's typically reserved for situations where milder options have failed or aren't expected to work.

It is not meant for everyday or long-term use unless the pain remains severe and alternatives continue to fall short. Prescribers carefully weigh the benefits against the real risks before starting tramadol.

See full Tramadol drug information
Keep checking

Other Drugs & Mercury Herb

Browse every other medication we’ve checked against Mercury Herb — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mercury Herb against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mercury Herb list.

See the full Mercury Herb interactions page
See every supplement checked against Tramadol, ranked by severity
Evidence & sources

Mercury Herb References

The 3 references that drive our Mercury Herb monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Vallverdu A, Garcia-Ortega P, Martinez J, et al. Mercurialis annua: characterization of main allergens and cross- reactivity with other species. Int Arch Allergy Immunol 1997;112:356-64. PubMed
  3. Garcia-Ortega P, Martinez J, Martinez A, et al. Mercurialis annua pollen: a new source of allergic sensitization and respiratory disease. J Allergy Clin Immunol 1992;89:987-93.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mercury Herb and Tramadol Together: Common Questions

Is it safe to take Mercury Herb with Tramadol?
We do not list a known interaction between Mercury Herb and Tramadol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mercury Herb and Tramadol have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Tramadol interact with any supplements?
Yes. Tramadol has documented interactions with 223 supplements in our database — Mercury Herb is not one of them. The Tramadol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mercury Herb monograph Uses, safety profile, and every drug interaction in one place Tramadol drug information The full plain-English guide to this medication Tramadol supplement interactions Every supplement checked against Tramadol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tramadol and Mercury Herb?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.