Drug & supplement interaction

Monterey Pine + Avapritinib

Avapritinib brand name: Ayvakit.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Monterey Pine and Avapritinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Avapritinib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Monterey Pine and Avapritinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Avapritinib and Monterey Pine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Monterey Pine at all — not against Avapritinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Monterey Pine safety at a glance

Monterey Pine overall Not established There is little human safety data for Monterey Pine taken as a supplement.
Pregnancy Avoid Safety is not established, so it is best to avoid during pregnancy.
Breastfeeding Avoid Safety is not established, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Avapritinib and Monterey Pine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Monterey Pine and Avapritinib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Monterey Pine

    “Contact dermatitis from Monterey pine sawdust has been reported.”

    Monterey Pine · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 63615. Burry, J. N. Environmental dermatitis: contact dermatitis from Pinus radiata. Med J Aust. 7-2-1977;2(1):13-14. DOI

    Avapritinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Avapritinib. Read the label on DailyMed ›

Effects for Avapritinib come from the ADVERSE REACTIONS section of its FDA label; effects for Monterey Pine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 12,039 voluntary FDA FAERS reports for Avapritinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Avapritinib Products Have a Food Rule — Monterey Pine Should Not Break It

At least one FDA label for a product containing Avapritinib says to take it on an empty stomach. Most supplements — Monterey Pine included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Avapritinib on its own and move Monterey Pine to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Avapritinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.7 ) 2.1 Recommended Administration Administer AYVAKIT orally on an empty stomach, at least 1 hour before or 2 hours after a meal [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Avapritinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Avapritinib

This page covers Monterey Pine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Avapritinib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

Open the Avapritinib interaction page

One more smart check

Taking Monterey Pine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 43 real supplement products containing Monterey Pine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Monterey Pine. Even though Monterey Pine itself has no known interaction with Avapritinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Monterey Pine and Avapritinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Monterey Pine
Top half

#681 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Avapritinib
Steady interest

#1,422 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Monterey Pine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Monterey Pine and Avapritinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Monterey Pine

What is Monterey Pine?

Monterey Pine
  • Antioxidant support
  • Skin and aging concerns
  • Circulation support
  • Inflammation
  • Respiratory comfort

Monterey Pine is mainly a timber tree, and human evidence for its use as a supplement is very limited. Some pine bark extracts are studied for antioxidant effects, but most claims specific to Monterey Pine are not well proven. Talk to a pharmacist or doctor before using any pine-based product.

Pinus radiata · Pinaceae · Bark, needles, and essential oil · Bark extract supplements, essential oil, needle tea

An interaction check asks whether these two react with each other — it does not ask whether Monterey Pine is a good idea for someone in your situation. Here is what our Monterey Pine record says about it on its own.

Monterey Pine: dosing

There is no established standard dose for Monterey Pine. Because products vary widely in strength and form, a safe, proven amount has not been set.If you choose to use a pine-derived product, follow the directions on the label and do not exceed them. Essential oils are for external or aromatherapy use only unless a professional advises otherwise.

From our Monterey Pine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Monterey Pine monograph & all interactions
Medication

About Avapritinib

What Is Avapritinib Used For?

Brand name: Ayvakit

Ayvakit (avapritinib) is approved to treat adults with unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) gastrointestinal stromal tumors (GIST) that have a specific genetic mutation called a PDGFRA exon 18 mutation, including the D842V variant. Patients must be tested for this mutation before starting treatment.

Ayvakit is also approved to treat advanced systemic mastocytosis (AdvSM) — a serious condition where abnormal mast cells build up in organs — including aggressive systemic mastocytosis, systemic mastocytosis with an associated blood cancer, and mast cell leukemia. Additionally, Ayvakit treats indolent systemic mastocytosis (ISM), a less severe form of the disease. It is not recommended for either form of mastocytosis if platelet counts are too low (below 50 × 10⁹/L).

Most-Reported Side Effects for Avapritinib

From FAERS, the FDA’s public side-effect reporting system (12,039 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,735 reports
Nausea 1,218 reports
Diarrhea 1,007 reports
Headache 568 reports
Dizziness 537 reports
See full Avapritinib drug information
Keep checking

Other Drugs & Monterey Pine

Browse every other medication we’ve checked against Monterey Pine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Monterey Pine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Monterey Pine list.

See the full Monterey Pine interactions page
See every supplement checked against Avapritinib, ranked by severity
Evidence & sources

Monterey Pine References

The 1 references that drive our Monterey Pine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Burry, J. N. Environmental dermatitis: contact dermatitis from Pinus radiata. Med J Aust. 7-2-1977;2(1):13-14. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Monterey Pine and Avapritinib Together: Common Questions

Is it safe to take Monterey Pine with Avapritinib?
We do not list a known interaction between Monterey Pine and Avapritinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Monterey Pine and Avapritinib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Monterey Pine and Avapritinib at the same time of day?
At least one FDA label for a product containing Avapritinib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Avapritinib on its own and move Monterey Pine to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Avapritinib interact with any supplements?
Yes. Avapritinib has documented interactions with 138 supplements in our database — Monterey Pine is not one of them. The Avapritinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Monterey Pine monograph Uses, safety profile, and every drug interaction in one place Avapritinib drug information The full plain-English guide to this medication Avapritinib supplement interactions Every supplement checked against Avapritinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Avapritinib and Monterey Pine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.