Drug & supplement interaction

Myrrh + Leucovorin Calcium

Leucovorin Calcium brand name: Wellcovorin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Myrrh and Leucovorin Calcium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Myrrh and Leucovorin Calcium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leucovorin Calcium and Myrrh in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Myrrh safety at a glance

Myrrh overall Use caution Likely fine for short-term topical or mouth-rinse use, but oral safety is not well studied.
Pregnancy Likely Unsafe When used orally. Myrrh stimulates uterine tone and blood flow and may have an abortifacient effect. There is insufficient reliable information available about... Read the full pregnancy detail
Breastfeeding Avoid Not enough safety information is available, so it is best avoided.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leucovorin Calcium and Myrrh? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Leucovorin Calcium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Leucovorin Calcium is filed under a single classification — oral drugs. Myrrh has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and warfarin (coumadin) (moderate) — and none of Leucovorin Calcium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Myrrh Does Interact With Other Medications

Myrrh has 88 moderate known drug interactions in our database — Leucovorin Calcium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 88 No known interaction 2,742 (incl. Leucovorin Calcium)
Taking anything else?

Check Another of Your Medications Against Myrrh

Covers the 2,830 medications we’ve checked against Myrrh. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Myrrh and Leucovorin Calcium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea reported in 9.5% of FDA reports for Leucovorin Calcium Additional detail

    Myrrh

    “Orally, myrrh may cause diarrhea in some patients when taken at doses of 2-4 grams (12,19).”

    Myrrh · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    Leucovorin Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Leucovorin Calcium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Myrrh

    “Topically, myrrh has been reported to cause dermatitis (6).”

    Myrrh · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    Leucovorin Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Leucovorin Calcium. Read the label on DailyMed ›

Reported for Myrrh but not commonly for Leucovorin Calcium: stomach pain, swelling and itching.

Effects for Leucovorin Calcium come from the ADVERSE REACTIONS section of its FDA label; effects for Myrrh come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 19,003 voluntary FDA FAERS reports for Leucovorin Calcium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Myrrh in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Myrrh stimulates uterine tone and blood flow and may have an abortifacient effect. There is insufficient reliable information available about the safety of the topical use of myrrh during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Leucovorin Calcium Is Prescribed For, and What Myrrh Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Leucovorin Calcium is a prescription medicine with approved uses on its FDA label. Myrrh is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Leucovorin Calcium is prescribed for: Leucovorin is used to reduce the harmful effects of methotrexate when the body is having trouble clearing it, and to counteract accidental overdoses of folic acid antagonists or dihydrofolate reductase (DHFR) inhibitors — drugs that block the body's ability to use folate. The oral tablet (Leucovorin Calcium) is approved for these uses in adults only. Vykoura injection is also approved to rescue adult and pediatric patients after high-dose methotrexate therapy. Leucovorin Calcium tablets are approved to treat cerebral folate transport deficiency (FOLR1-CFTD), a rare genetic condition that prevents the brain from getting enough folate, in adults and children.

Read the rest of what Leucovorin Calcium is prescribed for

Vykoura injection and leucovorin calcium injection are approved to treat megaloblastic anemia (low red blood cell counts caused by folate deficiency) when oral treatment isn't an option, and to be used alongside fluorouracil (5-FU) to treat metastatic colorectal cancer.

Myrrh has been studied for:

  • Cancer studied, not established Myrrh has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Myrrh for cancer

    Although there has been interest in using oral myrrh for cancer, there is insufficient reliable information about the clinical effects of myrrh for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Leucovorin Calcium on your own; if you are taking Myrrh for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Leucovorin Calcium

This page covers Myrrh only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leucovorin Calcium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Leucovorin Calcium interaction page

One more smart check

Taking Myrrh as Part of a Dietary Supplement Product? Check It for Interactions

We hold 458 real supplement products containing Myrrh, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Myrrh. Even though Myrrh itself has no known interaction with Leucovorin Calcium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Myrrh and Leucovorin Calcium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Myrrh
Top 25%

#318 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Leucovorin Calcium
Top half

#1,101 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Myrrh reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Myrrh and Leucovorin Calcium records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Myrrh

What is Myrrh?

Myrrh
  • Mouth and gum irritation
  • Sore throat
  • Minor wound and skin care
  • Digestive upset
  • Antimicrobial/antiseptic uses

Myrrh is a fragrant gum resin from Commiphora trees that has long been used in mouthwashes, throat remedies, and skin care. Modern evidence for most of its uses is limited and comes mostly from laboratory or small studies, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy.

Commiphora myrrha · Burseraceae · Gum resin (and essential oil distilled from the resin) · Tincture, mouthwash/gargle, capsules, powder, essential oil, topical preparations, incense

An interaction check asks whether these two react with each other — it does not ask whether Myrrh is a good idea for someone in your situation. Here is what our Myrrh record says about it on its own.

Myrrh: dosing

There is no well-established standard dose of myrrh for any condition. Strengths vary widely between tinctures, mouthwashes, capsules, and essential oils.The safest approach is to follow the directions on the product label and not exceed them. Mouthwashes and gargles are usually diluted and not swallowed. Essential oil should never be swallowed and must be diluted before applying to the skin.

From our Myrrh monograph — the full record covers uses, side effects and every documented interaction.

Read the full Myrrh monograph & all interactions
Medication

About Leucovorin

What Is Leucovorin Used For?

Brand name: Wellcovorin

Leucovorin is used to reduce the harmful effects of methotrexate when the body is having trouble clearing it, and to counteract accidental overdoses of folic acid antagonists or dihydrofolate reductase (DHFR) inhibitors — drugs that block the body's ability to use folate. The oral tablet (Leucovorin Calcium) is approved for these uses in adults only. Vykoura injection is also approved to rescue adult and pediatric patients after high-dose methotrexate therapy.

Leucovorin Calcium tablets are approved to treat cerebral folate transport deficiency (FOLR1-CFTD), a rare genetic condition that prevents the brain from getting enough folate, in adults and children. Vykoura injection and leucovorin calcium injection are approved to treat megaloblastic anemia (low red blood cell counts caused by folate deficiency) when oral treatment isn't an option, and to be used alongside fluorouracil (5-FU) to treat metastatic colorectal cancer.

Most-Reported Side Effects for Leucovorin Calcium

From FAERS, the FDA’s public side-effect reporting system (19,003 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 1,799 reports
Nausea 1,388 reports
Vomiting 1,135 reports
Neutropenia 1,094 reports
Fever 1,011 reports
See full Leucovorin drug information
Keep checking

Other Drugs & Myrrh

Browse every other medication we’ve checked against Myrrh — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
88Moderate
0Minor
2,741No known interaction
88 Moderate 2,741 No interaction
Moderate

88 interactions

Showing 60 of 88 moderate interactions — see all 88 on the Myrrh page.

No interaction 2,741 drugs checked — show the list

We also checked Myrrh against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,741 medications checked with no known interaction — see the full Myrrh list.

See the full Myrrh interactions page
See every supplement checked against Leucovorin Calcium, ranked by severity
Evidence & sources

Myrrh References

The 8 references that drive our Myrrh monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Al Faraj S. Antagonism of the anticoagulant effect of warfarin caused by the use of Commiphora molmol as a herbal medication: a case report. Ann Trop Med Parasitol 2005;99:219-20.
  6. Al-Jaroudi D, Kaddour O, Al-Amin N. Risks of myrrh use in pregnancy. JBRA Assist Reprod 2016;20(4):257-8.
  7. Xu YY, Li L, Xuan L, Guan K. Patch test diagnosis of non-immediate cutaneous reaction to myrrh following oral intake of a traditional Chinese medicine decoction. Contact Dermatitis. 2019;80(2):135-136. PubMed
  8. Al-Romaiyan A, Huang GC, Jones P, Persaud S. Commiphora myrrha stimulates insulin secretion from mouse and human islets of Langerhans. J Ethnopharmacol. 2021 Jan 10;264:113075. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Myrrh and Leucovorin Calcium Together: Common Questions

Is it safe to take Myrrh with Leucovorin Calcium?
We do not list a known interaction between Myrrh and Leucovorin Calcium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Myrrh and Leucovorin Calcium have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Myrrh and Leucovorin Calcium used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Myrrh in each. That is a conversation for your prescriber, especially if Leucovorin Calcium is being adjusted to a target.
How was the Myrrh and Leucovorin Calcium combination checked?
Interactions in our licensed database are recorded against drug classes. Leucovorin Calcium is filed under 1 classification, and Myrrh has documented interactions with 2 drug classes — none of Leucovorin Calcium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Myrrh interact with any other medications?
Yes. Myrrh has 88 documented drug interactions in our database — Leucovorin Calcium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Leucovorin Calcium interact with any supplements?
Yes. Leucovorin Calcium has documented interactions with 17 supplements in our database — Myrrh is not one of them. The Leucovorin Calcium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Myrrh monograph Uses, safety profile, and every drug interaction in one place Leucovorin drug information The full plain-English guide to this medication Leucovorin Calcium supplement interactions Every supplement checked against Leucovorin Calcium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leucovorin Calcium and Myrrh?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.