Drug & supplement interaction

Nasturtium + Talbutal

Talbutal brand name: Lotusate.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Nasturtium and Talbutal in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Nasturtium and Talbutal

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Talbutal and Nasturtium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Nasturtium at all — not against Talbutal, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nasturtium safety at a glance

Nasturtium overall Use caution Generally considered safe as a food, but concentrated extracts have limited safety data.
Pregnancy Avoid Not enough safety information; medicinal amounts are best avoided during pregnancy.
Breastfeeding Use caution Safety during breastfeeding is not well studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Talbutal and Nasturtium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Nasturtium Itself Has Been Linked To

This is not an interaction — nothing below involves Talbutal. It is the side-effect record for Nasturtium on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Nasturtium, this list is the first place to look.

  • A skin rash Additional detail

    “Orally, large amounts of nasturtium or benzyl mustard oil, a constituent of nasturtium, can cause gastrointestinal tract irritation (2,18). Large amounts of nasturtium can cause albuminuria due to glomerular and tubular damage (2).

    Topically, contact with the nasturtium plant and its benzyl mustard oil constituent can cause skin and mucosal irritation (2,18).”

    Nasturtium · Natural Medicines adverse-effect record, reported in albuminuria.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 99386. Perez-Crespo M, Silvestre JF, Mataix J, Ballester I, Toledo F, Betlloch I. Contact dermatitis due to nasturtium. Contact Dermatitis. 2009;60(4):229-30. PubMed

    “Topically, contact with the nasturtium plant and its benzyl mustard oil constituent can cause skin and mucosal irritation (2,18). Benzyl mustard oil is a contact allergen if applied to the skin. There are multiple case reports of contact dermatitis attributed to nasturtium.”

    Nasturtium · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 99386. Perez-Crespo M, Silvestre JF, Mataix J, Ballester I, Toledo F, Betlloch I. Contact dermatitis due to nasturtium. Contact Dermatitis. 2009;60(4):229-30. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Nasturtium — expand a row for the licensed statement it rests on. We haven’t matched Talbutal to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Talbutal.

Everything else you take

See Every Supplement That Interacts With Talbutal

This page covers Nasturtium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Talbutal page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Talbutal page

“Every one of the 17 supplements that interacts with Talbutal (Lotusate) works through your gut, changing how much of this barbiturate sleep aid actually reaches your bloodstream. That deserves genuine caution, because barbiturates leave little room for error.”

Reviewed by 2 · Jul 18, 2026

Open the Talbutal interaction page

One more smart check

Taking Nasturtium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Nasturtium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nasturtium. Even though Nasturtium itself has no known interaction with Talbutal, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Nasturtium and Talbutal Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nasturtium
Top half

#535 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Talbutal
Steady interest

#2,752 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nasturtium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nasturtium and Talbutal records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Nasturtium

What is Nasturtium?

  • Urinary tract infections
  • Respiratory infections and congestion
  • Antimicrobial support
  • Wound and skin care (topical)
  • Mild cold and cough symptoms

Nasturtium is an edible garden plant traditionally used for urinary and respiratory infections, often combined with horseradish in herbal products. Some lab studies suggest it has antimicrobial activity, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have kidney or stomach problems.

Tropaeolum majus · Tropaeolaceae · Leaves, flowers, and seeds · Fresh leaves and flowers (food/salad), dried herb, tea, capsules, tinctures, and combination herbal products

An interaction check asks whether these two react with each other — it does not ask whether Nasturtium is a good idea for someone in your situation. Here is what our Nasturtium record says about it on its own.

Nasturtium: dosing

There is no well-established standardized dose for nasturtium. Amounts vary widely depending on whether you use fresh leaves, dried herb, tea, capsules, or a combination product.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Nasturtium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nasturtium monograph & all interactions
Keep checking

Other Drugs & Nasturtium

Browse every other medication we’ve checked against Nasturtium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Nasturtium References

The 5 references that drive our Nasturtium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Fintelmann V, Albrecht U, Schmitz G, Schnitker J. Efficacy and safety of a combination herbal medicinal product containing Tropaeoli majoris herba and Armoraciae rusticanae radix for the prophylactic treatment of patients with respiratory tract diseases:
  4. Albrecht U, Goos KH, Schneider B. A randomised, double-blind, placebo-controlled trial of a herbal medicinal product containing Tropaeoli majoris herba (Nasturtium) and Armoraciae rusticanae radix (Horseradish) for the prophylactic treatment of patients w
  5. Perez-Crespo M, Silvestre JF, Mataix J, Ballester I, Toledo F, Betlloch I. Contact dermatitis due to nasturtium. Contact Dermatitis. 2009;60(4):229-30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nasturtium and Talbutal Together: Common Questions

Is it safe to take Nasturtium with Talbutal?
We do not list a known interaction between Nasturtium and Talbutal. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Talbutal interact with any supplements?
Yes. Talbutal has documented interactions with 17 supplements in our database — Nasturtium is not one of them. The Talbutal interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Talbutal and Nasturtium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.