Drug & supplement interaction

Osha + Crofelemer

Crofelemer brand names: Fulyzaq, Mytesi.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Osha and Crofelemer in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Osha and Crofelemer

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Crofelemer and Osha in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Osha at all — not against Crofelemer, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Osha safety at a glance

Osha overall Use caution Limited safety data exist, and wild osha can be confused with poisonous look-alike plants.

Pregnancy Likely Unsafe When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated. Read the full pregnancy detail

Breastfeeding Avoid No reliable safety data are available, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Crofelemer and Osha? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Crofelemer’s Own FDA Label Lists

This is not an interaction — none of it involves Osha. These are the most notable effects listed in the ADVERSE REACTIONS section of Crofelemer’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

Yellowing of the skin or eyes Worth acting on
A higher chance of infection Worth acting on
Bloating or gas
Back pain
Cough
Joint pain
Muscle pain
Nausea

From the ADVERSE REACTIONS section of the FDA label for Crofelemer. Read the label on DailyMed › Where a percentage is shown, it is the share of 233 voluntary FDA FAERS reports for Crofelemer that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Osha’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Osha side to compare — that is a limit of the record, not a statement that Osha has no side effects.

Special populations

Osha in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Crofelemer Is Prescribed For, and What Osha Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Crofelemer is a prescription medicine with approved uses on its FDA label. Osha is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Crofelemer is prescribed for: Mytesi (crofelemer) is approved to provide symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy. It is not intended to treat diarrhea caused by an infection. Before starting Mytesi, a doctor will rule out infectious causes of diarrhea.

Osha has been studied for:

HIV/AIDS studied, not established Osha has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Osha for hiv/aids

Although there has been interest in using oral osha for HIV/AIDS, there is insufficient reliable information about the clinical effects of osha for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Crofelemer on your own; if you are taking Osha for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Crofelemer

This page covers Osha only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Crofelemer page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Crofelemer interaction page

One more smart check

Taking Osha as Part of a Dietary Supplement Product? Check It for Interactions

We hold 336 real supplement products containing Osha, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Osha. Even though Osha itself has no known interaction with Crofelemer, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Osha and Crofelemer Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Osha

Top half

#459 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Crofelemer

Steady interest

#2,581 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Osha reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Osha and Crofelemer records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Osha

What is Osha?

Cough and sore throat
Respiratory infections and colds
Immune support
Digestive upset
Bronchitis and congestion

Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats. Solid human research is lacking, so its benefits remain unproven, and it should be avoided during pregnancy and breastfeeding. Talk to your pharmacist or doctor before trying it.

Ligusticum porteri · Apiaceae · Root · Tea, tincture, capsules, lozenges, chewed raw root

An interaction check asks whether these two react with each other — it does not ask whether Osha is a good idea for someone in your situation. Here is what our Osha record says about it on its own.

Osha: dosing

There is no established standard dose for osha. The right amount depends on the form (tea, tincture, capsule, or lozenge) and the product's strength.If you choose to use osha, follow the directions on the product label and do not exceed them.

From our Osha monograph — the full record covers uses, side effects and every documented interaction.

Read the full Osha monograph & all interactions

Medication

About Crofelemer

What Is Crofelemer Used For?

Brand names: Fulyzaq, Mytesi

Mytesi (crofelemer) is approved to provide symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

It is not intended to treat diarrhea caused by an infection. Before starting Mytesi, a doctor will rule out infectious causes of diarrhea.

Most-Reported Side Effects for Crofelemer

From FAERS, the FDA’s public side-effect reporting system (233 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 26 reports

Anxiety 14 reports

Emotional distress 14 reports

Anhedonia 12 reports

Fatigue 11 reports

See full Crofelemer drug information

Keep checking

Other Drugs & Osha

Browse every other medication we’ve checked against Osha — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Osha against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Osha list.

See the full Osha interactions page

See every supplement checked against Crofelemer, ranked by severity

Evidence & sources

Osha References

The 2 references that drive our Osha monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Osha and Crofelemer Together: Common Questions

Is it safe to take Osha with Crofelemer?

We do not list a known interaction between Osha and Crofelemer. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Osha and Crofelemer used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Osha in each. That is a conversation for your prescriber, especially if Crofelemer is being adjusted to a target.

Does Crofelemer interact with any supplements?

Yes. Crofelemer has documented interactions with 17 supplements in our database — Osha is not one of them. The Crofelemer interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Osha monograph Uses, safety profile, and every drug interaction in one place Crofelemer drug information The full plain-English guide to this medication Crofelemer supplement interactions Every supplement checked against Crofelemer, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Crofelemer and Osha?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.