Drug & supplement interaction

Pagoda Tree + Butenafine

Butenafine brand name: Mentax.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pagoda Tree and Butenafine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pagoda Tree and Butenafine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Butenafine and Pagoda Tree in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pagoda Tree safety at a glance

Pagoda Tree overall Use caution Generally used in traditional medicine, but human safety data are limited, so use cautiously.
Pregnancy Possibly Unsafe When the seed is used orally; avoid using. There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When the seed is used orally; avoid using. There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Butenafine and Pagoda Tree? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Butenafine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Butenafine is filed under 2 classifications — antifungals, oral drugs. Pagoda Tree has documented interactions with 1 drug class — the most serious being caffeine (moderate) — and none of Butenafine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pagoda Tree Does Interact With Other Medications

Pagoda Tree has 29 moderate known drug interactions in our database — Butenafine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 29 No known interaction 2,801 (incl. Butenafine)
Taking anything else?

Check Another of Your Medications Against Pagoda Tree

Covers the 2,830 medications we’ve checked against Pagoda Tree. Pick one to open its full report.

What to actually watch for

What Pagoda Tree Itself Has Been Linked To

This is not an interaction — nothing below involves Butenafine. It is the side-effect record for Pagoda Tree on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pagoda Tree, this list is the first place to look.

  • Swelling Additional detail

    “Orally, pagoda tree flower and fruit seem to be well tolerated. No adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted. The pagoda tree seed is possibly unsafe when consumed long-term.

    Serious Adverse Effects (Rare):

    Orally: With use of the seed, death and edema.”

    Pagoda Tree · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    “Orally, using pagoda tree seed long-term may cause edema and death (18).”

    Pagoda Tree · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Pagoda Tree — expand a row for the licensed statement it rests on. We haven’t matched Butenafine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Butenafine.

Special populations

Pagoda Tree in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When the seed is used orally; avoid using. There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Butenafine

This page covers Pagoda Tree only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Butenafine page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 12 minor.

From our pharmacist’s overview on the Butenafine page

“Butenafine (Mentax), an antifungal cream for athlete's foot, jock itch, and ringworm, carries a supplement list that deserves real vigilance, and most of that vigilance points at one entry. Activated charcoal, the only major-rated interaction of the 20 on file, can reduce the body's exposure to many drugs regardless of how they were gi…”

Reviewed by 2 · Jul 18, 2026

Open the Butenafine interaction page

One more smart check

Taking Pagoda Tree as Part of a Dietary Supplement Product? Check It for Interactions

We hold 162 real supplement products containing Pagoda Tree, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pagoda Tree. Even though Pagoda Tree itself has no known interaction with Butenafine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pagoda Tree and Butenafine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pagoda Tree
Top half

#484 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Butenafine
Steady interest

#1,913 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pagoda Tree reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pagoda Tree and Butenafine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pagoda Tree

What is Pagoda Tree?

  • Supporting blood vessel and capillary health
  • Bleeding-related complaints (traditional use)
  • Source of the flavonoid rutin
  • General antioxidant support
  • Skin and circulation health (topical/cosmetic use)

Pagoda Tree (Styphnolobium japonicum, also called the Japanese pagoda tree) is a traditional Asian medicinal plant best known as a natural source of the flavonoid rutin. While it has a long history in traditional Chinese medicine and some lab interest, strong human evidence for most uses is limited. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or take other medicines.

Styphnolobium japonicum · Fabaceae · Flowers, flower buds, and fruit (pods); sometimes leaves · Dried flower buds, teas, powders, capsules, and standardized extracts

An interaction check asks whether these two react with each other — it does not ask whether Pagoda Tree is a good idea for someone in your situation. Here is what our Pagoda Tree record says about it on its own.

Pagoda Tree: dosing

There is no well-established standard dose of Pagoda Tree for any health condition. Traditional preparations and modern supplements vary widely in strength and form.If you choose to use a product, follow the directions on the label and do not exceed the suggested amount.

From our Pagoda Tree monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pagoda Tree monograph & all interactions
Medication

About Butenafine

What Is Butenafine Used For?

Brand name: Mentax

Butenafine treats common fungal skin infections. Products containing butenafine — including Athletes Foot, Athletes Foot Ultra, Butenafine Hydrochloride, Butenafine Hydrochloride 1%, Jock Itch, and Jock Itch Cream — cure most cases of athlete's foot (between the toes), jock itch, and ringworm. They also relieve the itching, burning, cracking, and scaling that come with these infections.

For athlete's foot, these products work between the toes. Effectiveness on the bottom or sides of the foot is not established. Jock Itch and Jock Itch Cream are specifically indicated for jock itch and its associated symptoms.

See full Butenafine drug information
Keep checking

Other Drugs & Pagoda Tree

Browse every other medication we’ve checked against Pagoda Tree — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
29Moderate
0Minor
2,800No known interaction
29 Moderate 2,800 No interaction
Moderate

29 interactions

No interaction 2,800 drugs checked — show the list

We also checked Pagoda Tree against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,800 medications checked with no known interaction — see the full Pagoda Tree list.

See the full Pagoda Tree interactions page
See every supplement checked against Butenafine, ranked by severity
Evidence & sources

Pagoda Tree References

The 2 references that drive our Pagoda Tree monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pagoda Tree and Butenafine Together: Common Questions

Is it safe to take Pagoda Tree with Butenafine?
We do not list a known interaction between Pagoda Tree and Butenafine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Pagoda Tree and Butenafine combination checked?
Interactions in our licensed database are recorded against drug classes. Butenafine is filed under 2 classifications, and Pagoda Tree has documented interactions with 1 drug class — none of Butenafine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pagoda Tree interact with any other medications?
Yes. Pagoda Tree has 29 documented drug interactions in our database — Butenafine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Butenafine interact with any supplements?
Yes. Butenafine has documented interactions with 20 supplements in our database — Pagoda Tree is not one of them. The Butenafine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pagoda Tree monograph Uses, safety profile, and every drug interaction in one place Butenafine drug information The full plain-English guide to this medication Butenafine supplement interactions Every supplement checked against Butenafine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Butenafine and Pagoda Tree?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.