Drug & supplement interaction

Parsley Piert + Mercaptopurine

Mercaptopurine brand name: Purixan.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Parsley Piert and Mercaptopurine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Parsley Piert and Mercaptopurine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mercaptopurine and Parsley Piert in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Parsley Piert at all — not against Mercaptopurine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Parsley Piert safety at a glance

Parsley Piert overall Use caution Generally used in small amounts traditionally, but it is poorly studied in modern research.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mercaptopurine and Parsley Piert? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Mercaptopurine’s Own FDA Label Lists

This is not an interaction — none of it involves Parsley Piert. These are the most notable effects listed in the ADVERSE REACTIONS section of Mercaptopurine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on
  • A low white blood cell count Worth acting on mentioned in 11.0% of FDA reports for Mercaptopurine
  • Pancreatitis Worth acting on
  • A low platelet count Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • Hives Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Fever mentioned in 17.9% of FDA reports for Mercaptopurine

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Mercaptopurine. Read the label on DailyMed › Where a percentage is shown, it is the share of 17,242 voluntary FDA FAERS reports for Mercaptopurine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Parsley Piert’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Parsley Piert side to compare — that is a limit of the record, not a statement that Parsley Piert has no side effects.

From our Q&A

Questions About Parsley Piert or Mercaptopurine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Parsley Piert or Mercaptopurine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Mercaptopurine

This page covers Parsley Piert only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mercaptopurine page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 4 major · 92 moderate · 10 minor.

From our pharmacist’s overview on the Mercaptopurine page

“Mercaptopurine (Purixan) works by deliberately suppressing the immune system, whether for leukemia or inflammatory bowel disease, and the supplement interactions on this page deserve genuine care rather than a quick skim. Two problems dominate.”

Reviewed by 2 · Jul 18, 2026

Open the Mercaptopurine interaction page

How much people look this up

Where Parsley Piert and Mercaptopurine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Parsley Piert
Steady interest

#1,356 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mercaptopurine
Steady interest

#2,029 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Parsley Piert is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Parsley Piert reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Parsley Piert and Mercaptopurine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Parsley Piert

What is Parsley Piert?

  • Kidney and bladder stones
  • Urinary tract complaints
  • Mild fluid retention
  • Bladder irritation
  • General 'kidney cleansing' tonic

Parsley piert is a small traditional herb used mainly in folk medicine for kidney and bladder problems, especially stones. There is very little modern scientific research to confirm it works for any condition, so claims rest mostly on long-standing traditional use. Talk to your pharmacist or doctor before using it, and never use it to replace proven treatment for kidney stones or urinary problems.

Aphanes arvensis · Rosaceae · Above-ground parts (whole herb) · Tea (infusion), liquid extract/tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Parsley Piert is a good idea for someone in your situation. Here is what our Parsley Piert record says about it on its own.

Parsley Piert: dosing

There is no established, standardized dose of parsley piert. Traditional use involved making a tea from the dried herb or taking a liquid extract, but reliable dosing information from research is lacking.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Parsley Piert monograph — the full record covers uses, side effects and every documented interaction.

Read the full Parsley Piert monograph & all interactions
Medication

About Mercaptopurine

What Is Mercaptopurine Used For?

Brand name: Purixan

Mercaptopurine — available as a tablet and as an oral suspension — is used to treat acute lymphoblastic leukemia (ALL), a type of blood cancer. It is given as part of a combination chemotherapy maintenance regimen, meaning it works alongside other cancer medicines to keep leukemia in remission.

Both the tablet form and the oral suspension form carry this indication for adult and pediatric patients. The oral suspension is particularly useful for patients who cannot swallow tablets.

Most-Reported Side Effects for Mercaptopurine

From FAERS, the FDA’s public side-effect reporting system (17,242 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 1,904 reports
Fever 1,187 reports
Nausea 791 reports
Vomiting 749 reports
Abdominal pain 699 reports
See full Mercaptopurine drug information
Keep checking

Other Drugs & Parsley Piert

Browse every other medication we’ve checked against Parsley Piert — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Parsley Piert against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Parsley Piert list.

See the full Parsley Piert interactions page
See every supplement checked against Mercaptopurine, ranked by severity
Evidence & sources

Parsley Piert References

The 2 sources that drive our Parsley Piert monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Parsley Piert is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Parsley Piert and Mercaptopurine Together: Common Questions

Is it safe to take Parsley Piert with Mercaptopurine?
We do not list a known interaction between Parsley Piert and Mercaptopurine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Mercaptopurine interact with any supplements?
Yes. Mercaptopurine has documented interactions with 106 supplements in our database — Parsley Piert is not one of them. The Mercaptopurine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Parsley Piert monograph Uses, safety profile, and every drug interaction in one place Mercaptopurine drug information The full plain-English guide to this medication Mercaptopurine supplement interactions Every supplement checked against Mercaptopurine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mercaptopurine and Parsley Piert?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.