Pear + Ixazomib Citrate
Ixazomib Citrate brand name: Ninlaro.
We found no known interaction between Pear and Ixazomib Citrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ixazomib Citrate states a food rule worth keeping to.
Pear and Ixazomib Citrate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ixazomib Citrate and Pear in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pear at all — not against Ixazomib Citrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pear safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Pear in Pregnancy & Breastfeeding
When consumed in amounts commonly found in foods.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Ixazomib Citrate Products Have a Food Rule — Pear Should Not Break It
At least one FDA label for a product containing Ixazomib Citrate says to take it on an empty stomach. Most supplements — Pear included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Ixazomib Citrate on its own and move Pear to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ixazomib Citrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 ) Dose should be taken at least one hour before or at least two hours after food.
From the Dosage and Administration section of the FDA label we read for Ixazomib Citrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Ixazomib Citrate
This page covers Pear only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ixazomib Citrate page lists 168 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 124 moderate · 38 minor.
From our pharmacist’s overview on the Ixazomib Citrate page
“Anyone taking ixazomib citrate (Ninlaro) for multiple myeloma should give this list real weight, because a supplement that shifts this chemotherapy's blood level can shift how well it works against the cancer. Of the 168 ingredients on file, 121 act on CYP3A4, the enzyme that clears ixazomib.”
Reviewed by 2 · Jul 18, 2026
Taking Pear as Part of a Dietary Supplement Product? Check It for Interactions
We hold 793 real supplement products containing Pear, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pear. Even though Pear itself has no known interaction with Ixazomib Citrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pear and Ixazomib Citrate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#438 of 1,452 supplements looked up here in the last 7 days
#703 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pear reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pear and Ixazomib Citrate records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pear
What is Pear?
- Digestive health and constipation
- Hydration and general nutrition
- Cough and sore throat (traditional)
- Hangover relief (traditional)
- Antioxidant and heart health support
Pear is a common, nutritious fruit that provides fiber, water, vitamin C, and antioxidants, and it is a healthy part of most diets. Beyond its value as a food, evidence for pears as a medicinal supplement for specific conditions is limited, so enjoy it as part of a balanced diet rather than a treatment. If you have allergies or specific health concerns, check with your pharmacist or doctor.
Pyrus communis · Rosaceae · Fruit (commonly); leaves and fruit peel are sometimes used in traditional preparations · Fresh fruit, juice, dried fruit, fruit extracts, and powders
An interaction check asks whether these two react with each other — it does not ask whether Pear is a good idea for someone in your situation. Here is what our Pear record says about it on its own.
Pear: dosing
There is no established "medicinal dose" for pear, because it is mainly a food. Most people simply eat pears as part of a normal diet, such as one or more pieces of fruit per day.For pear juice, dried pear, or pear supplements and extracts, there is no standardized dose backed by strong evidence. Keep in mind that whole pears also provide fiber that juices and extracts may lack.
From our Pear monograph — the full record covers uses, side effects and every documented interaction.
About Ixazomib
What Is Ixazomib Used For?
Brand name: Ninlaro
Ninlaro (ixazomib) is used to treat multiple myeloma — a cancer of plasma cells in the bone marrow. It is always used together with two other medicines, lenalidomide and dexamethasone, and is approved for adults who have already tried at least one other treatment.
Ninlaro is not recommended as maintenance therapy or for newly diagnosed multiple myeloma in combination with lenalidomide and dexamethasone outside of controlled clinical trials.
Other Drugs & Pear
Browse every other medication we’ve checked against Pear — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pear against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pear list.
Pear References
The 4 references that drive our Pear monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6. PubMed
- Nieman DC, Gillitt ND, Sha W, et al. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res 2015;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. PubMed
- Lee HS, Isse T, Kawamoto T, Baik HW, Park JY, Yang M. Effect of Korean pear (Pyrus pyrifolia cv. Shingo) juice on hangover severity following alcohol consumption. Food Chem Toxicol 2013;58:101-6. doi: 10.1016/j.fct.2013.04.007.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pear and Ixazomib Citrate Together: Common Questions
Is it safe to take Pear with Ixazomib Citrate?
Should I take Pear and Ixazomib Citrate at the same time of day?
Does Ixazomib Citrate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Ixazomib Citrate and Pear?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.