Pear + Naloxone
Naloxone brand names: Narcan, Zimhi, Rivive.
We found no known interaction between Pear and Naloxone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Pear and Naloxone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Naloxone and Pear in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pear at all — not against Naloxone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pear safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Pear in Pregnancy & Breastfeeding
When consumed in amounts commonly found in foods.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Naloxone
This page covers Pear only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naloxone page lists 3 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (moderate), Gamma Butyrolactone (gbl) (moderate) and Gamma-hydroxybutyrate (ghb) (moderate).
By severity: 3 moderate.
From our pharmacist’s overview on the Naloxone page
“The list of supplements that interact with naloxone, the emergency spray or injection (Narcan, Zimhi, Rivive) that reverses opioid overdoses, is short and unusual. All three entries are forms of the same substance: gamma-hydroxybutyrate (GHB) and two chemicals the body converts into it, GBL and 1,4-butanediol.”
Reviewed by 2 · Jul 18, 2026
Taking Pear as Part of a Dietary Supplement Product? Check It for Interactions
We hold 793 real supplement products containing Pear, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pear. Even though Pear itself has no known interaction with Naloxone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pear and Naloxone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#431 of 1,452 supplements looked up here in the last 7 days
#1,429 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pear reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pear and Naloxone records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pear
What is Pear?
- Digestive health and constipation
- Hydration and general nutrition
- Cough and sore throat (traditional)
- Hangover relief (traditional)
- Antioxidant and heart health support
Pear is a common, nutritious fruit that provides fiber, water, vitamin C, and antioxidants, and it is a healthy part of most diets. Beyond its value as a food, evidence for pears as a medicinal supplement for specific conditions is limited, so enjoy it as part of a balanced diet rather than a treatment. If you have allergies or specific health concerns, check with your pharmacist or doctor.
Pyrus communis · Rosaceae · Fruit (commonly); leaves and fruit peel are sometimes used in traditional preparations · Fresh fruit, juice, dried fruit, fruit extracts, and powders
An interaction check asks whether these two react with each other — it does not ask whether Pear is a good idea for someone in your situation. Here is what our Pear record says about it on its own.
Pear: dosing
There is no established "medicinal dose" for pear, because it is mainly a food. Most people simply eat pears as part of a normal diet, such as one or more pieces of fruit per day.For pear juice, dried pear, or pear supplements and extracts, there is no standardized dose backed by strong evidence. Keep in mind that whole pears also provide fiber that juices and extracts may lack.
From our Pear monograph — the full record covers uses, side effects and every documented interaction.
About Naloxone Injection
What Is Naloxone Injection Used For?
Brand names: Narcan, Zimhi, Rivive
Naloxone Hydrochloride injection is used for the emergency treatment of known or suspected opioid overdose — reversing dangerous slowing of breathing and loss of consciousness caused by opioids. It is also approved for use in pediatric patients of all ages.
Naloxone Hydrochloride injection is additionally indicated specifically for military personnel and chemical incident responders: for emergency treatment of patients 12 and older where high-potency opioids such as fentanyl analogues have been used as a chemical weapon, and for temporary protection against breathing and nervous system depression when entering an area contaminated with such opioids. Zimhi (naloxone HCl) is a pre-filled, single-dose injectable product approved for intramuscular or subcutaneous use in known or suspected opioid overdose.
Other Drugs & Pear
Browse every other medication we’ve checked against Pear — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pear against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Acyclovir ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pear list.
Pear References
The 4 references that drive our Pear monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6. PubMed
- Nieman DC, Gillitt ND, Sha W, et al. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res 2015;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. PubMed
- Lee HS, Isse T, Kawamoto T, Baik HW, Park JY, Yang M. Effect of Korean pear (Pyrus pyrifolia cv. Shingo) juice on hangover severity following alcohol consumption. Food Chem Toxicol 2013;58:101-6. doi: 10.1016/j.fct.2013.04.007.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pear and Naloxone Together: Common Questions
Is it safe to take Pear with Naloxone?
Does Naloxone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.