Perilla + Megestrol Acetate
Megestrol Acetate brand names: Megestrol, Megace.
We found no known interaction between Perilla and Megestrol Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Perilla and Megestrol Acetate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Megestrol Acetate and Perilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Perilla at all — not against Megestrol Acetate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Perilla safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Megestrol Acetate Is Prescribed For, and What Perilla Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Megestrol Acetate is a prescription medicine with approved uses on its FDA label. Perilla is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Megestrol Acetate is prescribed for: Megestrol acetate is used for two distinct purposes depending on the formulation. Megestrol Acetate oral suspension is indicated for treating anorexia (loss of appetite), cachexia (severe weight loss and muscle wasting), or unexplained significant weight loss in patients with a diagnosis of AIDS. Megestrol Acetate tablets are used for the palliative treatment — meaning to ease symptoms, not cure — of advanced breast cancer or endometrial (uterine lining) cancer that is recurrent, inoperable, or has spread to other parts of the body. Tablets are not a replacement for surgery, radiation, or chemotherapy.
Perilla has been studied for:
-
Cancer studied, not established Perilla has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Perilla for cancer
Although there has been interest in using oral perilla for cancer, there is insufficient reliable information about the clinical effects of perilla for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Megestrol Acetate on your own; if you are taking Perilla for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Megestrol Acetate
This page covers Perilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Megestrol Acetate page lists 18 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 8 moderate · 9 minor.
From our pharmacist’s overview on the Megestrol Acetate page
“Megestrol acetate (Megace) is usually prescribed to restore appetite and weight in people who are seriously ill, so the drug only helps if it actually gets absorbed. That is exactly where this list earns real caution.”
Reviewed by 2 · Jul 18, 2026
Taking Perilla as Part of a Dietary Supplement Product? Check It for Interactions
We hold 199 real supplement products containing Perilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Perilla. Even though Perilla itself has no known interaction with Megestrol Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Perilla and Megestrol Acetate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#515 of 1,452 supplements looked up here in the last 7 days
#1,430 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Perilla reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Perilla and Megestrol Acetate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Perilla
What is Perilla?
- Seasonal and food allergies
- Asthma and airway inflammation
- Atopic dermatitis (eczema)
- Digestive upset
- General anti-inflammatory support
Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it should not replace proven treatments. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using concentrated supplements.
Perilla frutescens · Lamiaceae · Leaves, seeds, stem, and seed oil · Tea, capsules, seed oil, essential oil, dried leaf, culinary herb
An interaction check asks whether these two react with each other — it does not ask whether Perilla is a good idea for someone in your situation. Here is what our Perilla record says about it on its own.
Perilla: dosing
There is no well-established standard dose for perilla supplements. Products vary widely in their form and strength, from leaf teas to seed oil softgels to standardized extracts.The safest approach is to follow the directions on the product label and not to exceed them.
From our Perilla monograph — the full record covers uses, side effects and every documented interaction.
About Megestrol
What Is Megestrol Used For?
Brand names: Megestrol, Megace
Megestrol acetate is used for two distinct purposes depending on the formulation. Megestrol Acetate oral suspension is indicated for treating anorexia (loss of appetite), cachexia (severe weight loss and muscle wasting), or unexplained significant weight loss in patients with a diagnosis of AIDS.
Megestrol Acetate tablets are used for the palliative treatment — meaning to ease symptoms, not cure — of advanced breast cancer or endometrial (uterine lining) cancer that is recurrent, inoperable, or has spread to other parts of the body. Tablets are not a replacement for surgery, radiation, or chemotherapy.
Most-Reported Side Effects for Megestrol Acetate
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Perilla
Browse every other medication we’ve checked against Perilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Perilla against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Perilla list.
Perilla References
The 4 references that drive our Perilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
- Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
- Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Perilla and Megestrol Acetate Together: Common Questions
Is it safe to take Perilla with Megestrol Acetate?
Do Perilla and Megestrol Acetate have any of the same side effects?
Are Perilla and Megestrol Acetate used for the same thing?
Does Megestrol Acetate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.