Drug & supplement interaction

Phaseolus Vulgaris + Darolutamide

Darolutamide brand name: Nubeqa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Phaseolus Vulgaris and Darolutamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Darolutamide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phaseolus Vulgaris and Darolutamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Darolutamide and Phaseolus Vulgaris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phaseolus Vulgaris safety at a glance

Phaseolus Vulgaris overall Use caution Beans are a safe food when cooked, but concentrated extracts have less safety data and may cause digestive upset.
Pregnancy Use caution Beans as food are fine, but concentrated extracts are not well studied in pregnancy, so avoid them unless your doctor approves.
Breastfeeding Use caution Beans as food are fine, but there is little data on concentrated extracts during breastfeeding, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Darolutamide and Phaseolus Vulgaris? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Darolutamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Darolutamide is filed under 3 classifications — p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Phaseolus Vulgaris has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Darolutamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phaseolus Vulgaris Does Interact With Other Medications

Phaseolus Vulgaris has 86 moderate known drug interactions in our database — Darolutamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Darolutamide)
Taking anything else?

Check Another of Your Medications Against Phaseolus Vulgaris

Covers the 2,830 medications we’ve checked against Phaseolus Vulgaris. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Phaseolus Vulgaris and Darolutamide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation / Diarrhea / Nausea reported in 4.3% of FDA reports for Darolutamide Additional detail

    Phaseolus Vulgaris

    “Orally, an extract of the Phaseolus vulgaris variety white kidney bean, as well as alpha-amylase inhibitors isolated from Phaseolus vulgaris, might cause nausea, vomiting, diarrhea, flatulence, constipation, satiety, and stomach pains. Also, white kidney bean extract, taken orally along with carob gum, may cause constipation, flatulence, soft stools, and reduced levels of vitamin B12 and folic acid.”

    Phaseolus Vulgaris · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 11265. FDA Center for Food Safety and Nutrition. What are some of the questionable weight loss products? http://www.cfsan.fda.gov/~dms/qa-nut4.html. (Accessed 20 December 2003).
    2. 18223. Onakpoya I, Aldaas S, Terry R, Ernst E. The efficacy of Phaseolus vulgaris as a weight-loss supplement: a systematic review and meta-analysis of randomised clinical trials. Br J Nutr 2011;106:196-202.
    3. 29925. Boivin M, Flourie B, Rizza RA, Go VL, DiMagno EP. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology. 1988;94(2):387-94. PubMed
    4. 104874. Jalal SM, Alsultan AA, Alotaibi HH, Mary E, Alabdullatif AAI. Effect of Phaseolus vulgaris on urinary biochemical parameters among patients with kidney stones in Saudi Arabia. Nutrients. 2020 Oct 30;12(11):3346. PubMed
    5. 10633. Birketvedt GS, Travis A, Langbakk B, Florholmen JR. Dietary supplementation with bean extract improves lipid profile in overweight and obese subjects. Nutrition 2002;18:729-33.. PubMed
    6. 29916. Rodhouse JC, Haugh CA, Roberts D, Gilbert RJ. Red kidney bean poisoning in the UK: an analysis of 50 suspected incidents between 1976 and 1989. Epidemiol Infect 1990;105(3):485-91. PubMed

    Darolutamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Darolutamide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Phaseolus Vulgaris

    “Topically, Phaseolus vulgaris may cause contact dermatitis in sensitive individuals. A case of occupational contact dermatitis characterized by pruritus, erythema, eczema, and dyspnea has been reported for a 41-year-old farmer who handled the green parts of Phaseolus vulgaris.”

    Phaseolus Vulgaris · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 29920. Spiewak R, Dutkiewicz J. Occupational contact dermatitis to Phaseolus vulgaris in a farmer - a case report. Ann Agric Environ Med 2000;7(1):55-9.

    Darolutamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Darolutamide. Read the label on DailyMed ›

Reported for Phaseolus Vulgaris but not commonly for Darolutamide: an allergic reaction, stomach pain, a severe allergic reaction and bloating or gas.

Effects for Darolutamide come from the ADVERSE REACTIONS section of its FDA label; effects for Phaseolus Vulgaris come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 5,501 voluntary FDA FAERS reports for Darolutamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Darolutamide Products Have a Food Rule — Phaseolus Vulgaris Should Not Break It

At least one FDA label for a product containing Darolutamide says to take it with food. If you take Phaseolus Vulgaris on an empty stomach out of habit, keep them separate — and take Darolutamide with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Darolutamide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Take NUBEQA with food.

From the Dosage and Administration section of the FDA label we read for Darolutamide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Darolutamide

This page covers Phaseolus Vulgaris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Darolutamide page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 103 moderate · 38 minor.

From our pharmacist’s overview on the Darolutamide page

“Darolutamide (Nubeqa) treats prostate cancer, and supplements deserve real caution alongside it, because most of those listed here can change how much of the drug stays in your blood. Nearly all act on CYP3A4, the liver enzyme that breaks darolutamide down, or on the transport proteins that move it through cells.”

Reviewed by 2 · Jul 18, 2026

Open the Darolutamide interaction page

How much people look this up

Where Phaseolus Vulgaris and Darolutamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phaseolus Vulgaris
Steady interest

#1,075 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Darolutamide
Steady interest

#1,746 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phaseolus Vulgaris reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phaseolus Vulgaris and Darolutamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phaseolus Vulgaris

What is Phaseolus Vulgaris?

  • Weight management
  • Carbohydrate ('starch') blocking
  • Blood sugar support
  • General nutrition and fiber

Phaseolus vulgaris, the common bean, is widely eaten as food, and a concentrated white bean extract is marketed as a 'carb blocker' for weight loss. Some small studies suggest it may modestly reduce starch digestion, but the evidence for meaningful weight loss is limited and mixed. Talk to your pharmacist or doctor before using it as a supplement, and remember beans must be cooked thoroughly because raw or undercooked beans can be toxic.

Phaseolus vulgaris · Fabaceae · Seeds (beans), bean pods, and extracts of the seed · Capsules, tablets, powder, standardized white bean extract ('Phase 2'), whole beans as food

An interaction check asks whether these two react with each other — it does not ask whether Phaseolus Vulgaris is a good idea for someone in your situation. Here is what our Phaseolus Vulgaris record says about it on its own.

Phaseolus Vulgaris: dosing

There is no official standardized dose of Phaseolus vulgaris extract for weight loss or any other use. Products vary widely in strength and in how they are standardized (for example, by amount of alpha-amylase inhibitor activity).The safest approach is to follow the directions on the product label and not exceed them. Extract is usually taken shortly before starchy meals. Beans as food can simply be enjoyed as part of a balanced diet.

From our Phaseolus Vulgaris monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phaseolus Vulgaris monograph & all interactions
Medication

About Darolutamide

What Is Darolutamide Used For?

Brand name: Nubeqa

Nubeqa (darolutamide) tablets are approved for adult men with two forms of advanced prostate cancer. The first is non-metastatic castration-resistant prostate cancer (nmCRPC) — cancer that keeps growing despite hormone-lowering therapy and has not yet spread to other parts of the body. The second is metastatic castration-sensitive prostate cancer (mCSPC) — cancer that has spread but still responds to hormone-lowering treatment.

For mCSPC, Nubeqa can be used alone or in combination with docetaxel (a chemotherapy medicine). In all cases, patients also receive a gonadotropin-releasing hormone (GnRH) agonist or antagonist — a medicine that lowers testosterone — or have already had surgery to remove the testicles.

Most-Reported Side Effects for Darolutamide

From FAERS, the FDA’s public side-effect reporting system (5,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 829 reports
Hot flush 622 reports
Asthenia 352 reports
Dizziness 236 reports
Arthralgia 235 reports
See full Darolutamide drug information
Keep checking

Other Drugs & Phaseolus Vulgaris

Browse every other medication we’ve checked against Phaseolus Vulgaris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Phaseolus Vulgaris page.

No interaction 2,743 drugs checked — show the list

We also checked Phaseolus Vulgaris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Phaseolus Vulgaris list.

See the full Phaseolus Vulgaris interactions page
See every supplement checked against Darolutamide, ranked by severity
Evidence & sources

Phaseolus Vulgaris References

The 11 references that drive our Phaseolus Vulgaris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Birketvedt GS, Travis A, Langbakk B, Florholmen JR. Dietary supplementation with bean extract improves lipid profile in overweight and obese subjects. Nutrition 2002;18:729-33.. PubMed
  3. FDA Center for Food Safety and Nutrition. What are some of the questionable weight loss products? http://www.cfsan.fda.gov/~dms/qa-nut4.html. (Accessed 20 December 2003).
  4. Onakpoya I, Aldaas S, Terry R, Ernst E. The efficacy of Phaseolus vulgaris as a weight-loss supplement: a systematic review and meta-analysis of randomised clinical trials. Br J Nutr 2011;106:196-202.
  5. Rodhouse JC, Haugh CA, Roberts D, Gilbert RJ. Red kidney bean poisoning in the UK: an analysis of 50 suspected incidents between 1976 and 1989. Epidemiol Infect 1990;105(3):485-91. PubMed
  6. Spiewak R, Dutkiewicz J. Occupational contact dermatitis to Phaseolus vulgaris in a farmer - a case report. Ann Agric Environ Med 2000;7(1):55-9.
  7. Tjokroprawiro A, Pikir BS, Budhiarta AA, et al. Metabolic effects of onion and green beans on diabetic patients. Tohoku J Exp Med 1983;141 Suppl:671-6. PubMed
  8. Boivin M, Flourie B, Rizza RA, Go VL, DiMagno EP. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology. 1988;94(2):387-94. PubMed
  9. Ionescu-Tirgoviste, C., Popa, E., Mirodon, Z., Simionescu, M., and Mincu, I. [The effect of a plant mixture on the metabolic equilibrium in patients with type-2 diabetes mellitus]. Rev.Med Interna Neurol.Psihiatr.Neurochir.Dermatovenerol.Med Interna 1989
  10. He S, Simpson BK, Sun H, et al. Phaseolus vulgaris lectins: a systematic review of characteristics and health implications. Crit Rev Food Sci Nutr 2015 Oct 19:0. PubMed
  11. Jalal SM, Alsultan AA, Alotaibi HH, Mary E, Alabdullatif AAI. Effect of Phaseolus vulgaris on urinary biochemical parameters among patients with kidney stones in Saudi Arabia. Nutrients. 2020 Oct 30;12(11):3346. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phaseolus Vulgaris and Darolutamide Together: Common Questions

Is it safe to take Phaseolus Vulgaris with Darolutamide?
We do not list a known interaction between Phaseolus Vulgaris and Darolutamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phaseolus Vulgaris and Darolutamide have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Phaseolus Vulgaris and Darolutamide at the same time of day?
At least one FDA label for a product containing Darolutamide says to take it with food. If you take Phaseolus Vulgaris on an empty stomach out of habit, keep them separate and take Darolutamide with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Darolutamide products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Phaseolus Vulgaris and Darolutamide combination checked?
Interactions in our licensed database are recorded against drug classes. Darolutamide is filed under 3 classifications, and Phaseolus Vulgaris has documented interactions with 1 drug class — none of Darolutamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phaseolus Vulgaris interact with any other medications?
Yes. Phaseolus Vulgaris has 86 documented drug interactions in our database — Darolutamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Darolutamide interact with any supplements?
Yes. Darolutamide has documented interactions with 144 supplements in our database — Phaseolus Vulgaris is not one of them. The Darolutamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phaseolus Vulgaris monograph Uses, safety profile, and every drug interaction in one place Darolutamide drug information The full plain-English guide to this medication Darolutamide supplement interactions Every supplement checked against Darolutamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.