Drug & supplement interaction

Phaseolus Vulgaris + Pramlintide

Pramlintide brand name: Symlin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Phaseolus Vulgaris has a moderate interaction with Pramlintide. Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Phaseolus Vulgaris and Pramlintide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Pramlintide

Pramlintide falls under ANTIDIABETES DRUGS — the group Phaseolus Vulgaris interacts with.

Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Phaseolus vulgaris beans or bean pods, ingested alone or along with white mulberry leaf and bilberry, reduce blood glucose levels in some patients with diabetes.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Symlin (pramlintide). This isn't a liver-enzyme situation. Pramlintide already lowers blood sugar by slowing how fast food leaves your stomach, and you take it alongside mealtime insulin. White bean extract may modestly trim how much starch you absorb from a meal, which can nudge your blood sugar a little lower too. Stack those together and the worry is low blood sugar (hypoglycemia), with shakiness, sweating, dizziness, or confusion.

Honestly, this is a theoretical, anecdotal concern, not a strong proven one. Eating beans as regular food is unlikely to be the issue; a concentrated carb-blocker supplement is more the question mark. Please check with your pharmacist or doctor before adding it, and keep monitoring your sugars.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Tjokroprawiro A, Pikir BS, Budhiarta AA, et al. Metabolic effects of onion and green beans on diabetic patients. Tohoku J Exp Med 1983;141 Suppl:671-6. PubMed
  2. Boivin M, Flourie B, Rizza RA, Go VL, DiMagno EP. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology. 1988;94(2):387-94. PubMed
  3. Ionescu-Tirgoviste, C., Popa, E., Mirodon, Z., Simionescu, M., and Mincu, I. [The effect of a plant mixture on the metabolic equilibrium in patients with type-2 diabetes mellitus]. Rev.Med Interna Neurol.Psihiatr.Neurochir.Dermatovenerol.Med Interna 1989

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Phaseolus Vulgaris Also Interacts With Other Medications

Phaseolus Vulgaris has 85 moderate known drug interactions in our database — the Pramlintide one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Pramlintide)
Taking anything else?

Check Another of Your Medications Against Phaseolus Vulgaris

Covers the 2,830 medications we’ve checked against Phaseolus Vulgaris. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pramlintide

This page covers Phaseolus Vulgaris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pramlintide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Pramlintide page

“The single entry rated major on the pramlintide (Symlin) list is Siberian cocklebur, which has caused severe hypoglycemia in humans, not just in lab studies. That matters more than usual here because pramlintide is injected at mealtimes alongside insulin, and a dangerous low is already the main hazard of that pairing.”

Reviewed by 2 · Jul 18, 2026

Open the Pramlintide interaction page

How much people look this up

Where Phaseolus Vulgaris and Pramlintide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phaseolus Vulgaris
Steady interest

#1,185 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pramlintide
Steady interest

#2,063 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Phaseolus Vulgaris

What is Phaseolus Vulgaris?

  • Weight management
  • Carbohydrate ('starch') blocking
  • Blood sugar support
  • General nutrition and fiber

Phaseolus vulgaris, the common bean, is widely eaten as food, and a concentrated white bean extract is marketed as a 'carb blocker' for weight loss. Some small studies suggest it may modestly reduce starch digestion, but the evidence for meaningful weight loss is limited and mixed. Talk to your pharmacist or doctor before using it as a supplement, and remember beans must be cooked thoroughly because raw or undercooked beans can be toxic.

Read the full Phaseolus Vulgaris monograph & all interactions
Medication

About Pramlintide Injection

What Is Pramlintide Injection Used For?

Brand name: Symlin

SymlinPen (pramlintide) is used as an add-on treatment for adults with type 1 or type 2 diabetes who already use mealtime insulin but still haven't reached their target blood sugar levels — even with optimal insulin therapy.

It is not a replacement for insulin. It works alongside insulin, given right before major meals, to reduce the spike in blood sugar that happens after eating.

See full Pramlintide Injection drug information
Keep checking

Other Drugs & Phaseolus Vulgaris

Browse every other medication we’ve checked against Phaseolus Vulgaris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Phaseolus Vulgaris page.

No interaction 2,744 drugs checked — show the list

We also checked Phaseolus Vulgaris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Phaseolus Vulgaris list.

See the full Phaseolus Vulgaris interactions page
See every supplement checked against Pramlintide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Phaseolus Vulgaris monograph › Uses, safety, and every drug interaction in one place Pramlintide supplement interactions › Every supplement checked against Pramlintide, ranked by severity Pramlintide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Phaseolus Vulgaris and Pramlintide Together: Common Questions

Can you take Phaseolus Vulgaris with Pramlintide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Phaseolus Vulgaris and Pramlintide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pramlintide and Phaseolus Vulgaris?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.