Drug & supplement interaction

Phosphatidylcholine + nilotinib

nilotinib brand name: Tasigna.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Phosphatidylcholine and nilotinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phosphatidylcholine and nilotinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between nilotinib and Phosphatidylcholine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Phosphatidylcholine at all — not against nilotinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phosphatidylcholine safety at a glance

Phosphatidylcholin... overall Use caution Generally well tolerated in food and supplement amounts, but high doses may cause digestive upset.
Pregnancy Use caution Choline is needed in pregnancy, but supplement safety beyond food sources is not well studied; check with your doctor.
Breastfeeding Use caution Not enough reliable data on supplement use while breastfeeding; speak with your healthcare provider first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining nilotinib and Phosphatidylcholine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Phosphatidylcholine and nilotinib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Phosphatidylcholine

    “When taken orally, phosphatidylcholine may increase sweating and itching. When given subcutaneously, phosphatidylcholine can cause pain, burning, itching, tenderness to touch, bruising, edema, and erythema at the injection site. The pain, itching and erythema usually resolve within 2 days of treatment; however localized tenderness can last longer. Edema and bruising usually resolve within 10 days of treatment.”

    Phosphatidylcholine · Natural Medicines adverse-effect record, reported in erythema.

    6 sources cited
    1. 5229. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
    2. 63244. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
    3. 15623. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
    4. 15624. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
    5. 15626. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
    6. 15627. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed

    nilotinib

    Listed in the ADVERSE REACTIONS section of the FDA label for nilotinib. Read the label on DailyMed ›

  • A change in taste / Bloating or gas / Diarrhea / Vomiting Additional detail

    Phosphatidylcholine

    “Ingesting large amounts of phosphatidylcholine (30 grams per day) can cause gastrointestinal upset and diarrhea. However, bloating, diarrhea, altered taste, nausea, and vomiting have been reported with smaller doses. Although moderate subcutaneous doses do not usually cause systemic side effects, high doses exceeding 1.2 grams of phosphatidylcholine can cause nausea and abdominal pain in some people.”

    Phosphatidylcholine · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 5223. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
    2. 63244. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
    3. 68843. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
    4. 93389. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
    5. 93390. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
    6. 105728. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

    nilotinib

    Listed in the ADVERSE REACTIONS section of the FDA label for nilotinib. Read the label on DailyMed ›

  • Sweating / Itching / Swelling Additional detail

    Phosphatidylcholine

    Recorded for Phosphatidylcholine in the same Natural Medicines adverse-effect record shown under Bleeding or bruising above.

    nilotinib

    Listed in the ADVERSE REACTIONS section of the FDA label for nilotinib. Read the label on DailyMed ›

  • Stomach upset / Stomach pain Additional detail

    Phosphatidylcholine

    Recorded for Phosphatidylcholine in the same Natural Medicines adverse-effect record shown under A change in taste / Bloating or gas / Diarrhea / Vomiting above.

    nilotinib

    Listed in the ADVERSE REACTIONS section of the FDA label for nilotinib. Read the label on DailyMed ›

Showing the 10 most notable of 11 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Effects for nilotinib come from the ADVERSE REACTIONS section of its FDA label; effects for Phosphatidylcholine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Phosphatidylcholine or nilotinib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Phosphatidylcholine or nilotinib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With nilotinib

This page covers Phosphatidylcholine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the nilotinib page lists 221 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 176 moderate · 34 minor.

From our pharmacist’s overview on the nilotinib page

“Nilotinib (Tasigna) is a targeted therapy for chronic myeloid leukemia, cleared by the liver enzyme CYP3A4 and known to affect heart rhythm, so its supplement list calls for genuine care. Eleven of the 221 ingredients here carry a major rating, and those belong at the top of your reading.”

Reviewed by 2 · Jul 18, 2026

Open the nilotinib interaction page

One more smart check

Taking Phosphatidylcholine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,521 real supplement products containing Phosphatidylcholine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phosphatidylcholine. Even though Phosphatidylcholine itself has no known interaction with nilotinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phosphatidylcholine and nilotinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phosphatidylcholine
Top 25%

#216 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication nilotinib
Steady interest

#1,584 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phosphatidylcholine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phosphatidylcholine and nilotinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phosphatidylcholine

What is Phosphatidylcholine?

Phosphatidylcholine
  • Liver health
  • Memory and brain support
  • Ulcerative colitis
  • Source of choline
  • High cholesterol

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for most uses. It is generally well tolerated, but talk to your pharmacist or doctor before starting it.

Phospholipid derived from sources such as soybeans, sunflower, and egg yolk · Capsules, softgels, tablets, granules, liquid, and powder (sometimes as part of lecithin)

An interaction check asks whether these two react with each other — it does not ask whether Phosphatidylcholine is a good idea for someone in your situation. Here is what our Phosphatidylcholine record says about it on its own.

Phosphatidylcholine: dosing

There is no single official or standardized dose of phosphatidylcholine for supplement use. The amount in products varies widely depending on the source and form, and the studied amounts differ from one condition to another.The best approach is to follow the dosing directions on your specific product's label. Higher doses are more likely to cause stomach upset and other side effects.

From our Phosphatidylcholine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phosphatidylcholine monograph & all interactions
Medication

About Nilotinib

What Is Nilotinib Used For?

Brand name: Tasigna

  • Nilotinib is used to treat certain types of chronic myeloid leukemia (CML; a type of cancer of the white blood cells) who have recently found to have this condition in adults and children 1 year of age and older. It is also used to treat certain types of CML in adults whose disease could not be treated successfully with imatinib (Gleevec) or adults who cannot take imatinib because of side effects. Nilotinib is also used to treat certain types of CML in children 1 year of age or older whose disease could not be treated successfully with other tyrosine kinase inhibitor therapies or who cannot take these medications because of side effects. Nilotinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

See full Nilotinib drug information
Keep checking

Other Drugs & Phosphatidylcholine

Browse every other medication we’ve checked against Phosphatidylcholine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Phosphatidylcholine References

The 15 references that drive our Phosphatidylcholine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phosphatidylcholine and nilotinib Together: Common Questions

Is it safe to take Phosphatidylcholine with nilotinib?
We do not list a known interaction between Phosphatidylcholine and nilotinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phosphatidylcholine and nilotinib have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does nilotinib interact with any supplements?
Yes. nilotinib has documented interactions with 221 supplements in our database — Phosphatidylcholine is not one of them. The nilotinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About nilotinib and Phosphatidylcholine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.