Picamilon + Niacin, Lovastatin
Niacin, Lovastatin brand name: Advicor.
Picamilon has a moderate interaction with Niacin, Lovastatin. Picamilon is broken down into gamma-aminobutyric acid (GABA) and niacin after oral administration.
Read the full interaction reportPicamilon and Niacin, Lovastatin
Here is the interaction we found between these two, with the evidence behind it.
NIACIN
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind: your medication Advicor already contains niacin, and Picamilon is partly built from niacin too. When the body breaks Picamilon down, it releases extra niacin on top of what you're already taking. That means you could end up with more niacin in your system than intended, which can stack the usual niacin side effects, things like flushing, warmth or redness of the skin, itching, and sometimes headache or an upset stomach.
I want to be honest that this concern is theoretical. It's based on how these compounds work, not on real cases in people. Still, since you're already getting a steady niacin dose from Advicor, I'd run any Picamilon use by your pharmacist or doctor first rather than doubling up on your own.
- Avula B, Chittiboyina AG, Sagi S, et al. Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States. Drug Test Anal. 2016;8(3-4):334-43. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Picamilon Also Interacts With Other Medications
Picamilon has 2 moderate known drug interactions in our database — the Niacin, Lovastatin one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Picamilon
We haven’t checked that one against Picamilon yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Picamilon. Pick one to open its full report.
See Every Supplement That Interacts With Niacin, Lovastatin
This page covers Picamilon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Niacin, Lovastatin page lists 188 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).
By severity: 8 major · 141 moderate · 39 minor.
From our pharmacist’s overview on the Niacin, Lovastatin page
“Advicor pairs niacin with lovastatin to lower cholesterol, and because lovastatin is cleared by a single liver enzyme, CYP3A4, this list earns genuine respect. Of the 188 supplement and herbal ingredients on file, 121 interact through that one enzyme, and eight overall carry a major rating.”
Reviewed by 2 · Jul 18, 2026
Taking Picamilon as Part of a Dietary Supplement Product? Check It for Interactions
We hold 135 real supplement products containing Picamilon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picamilon. Your product may carry other ingredients that interact with Niacin, Lovastatin too, on top of Picamilon — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Picamilon and Niacin, Lovastatin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#325 of 1,452 supplements looked up here in the last 7 days
#712 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Picamilon
What is Picamilon?
- Anxiety and stress
- Mental focus and cognition
- Low mood
- Migraine or headache
- Fatigue and energy
Picamilon is a synthetic compound made by joining niacin (vitamin B3) and GABA, originally developed in the former Soviet Union as a prescription drug. It is sold in some countries as a supplement for anxiety, focus, and mood, but high-quality human evidence is very limited, and U.S. regulators have stated it does not qualify as a legal dietary supplement ingredient. Talk to a pharmacist or doctor before using it.
Other Drugs & Picamilon
Browse every other medication we’ve checked against Picamilon — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Picamilon against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Picamilon list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Niacin, Lovastatin Is Linked to Lower Levels of 2 Nutrients
Natural Medicines records Niacin, Lovastatin as a medicine that can lower these. This is not an interaction with Picamilon — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Niacin, Lovastatin nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Picamilon and Niacin, Lovastatin Together: Common Questions
Can you take Picamilon with Niacin, Lovastatin?
How serious is the Picamilon and Niacin, Lovastatin interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Niacin, Lovastatin and Picamilon?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.