Drug & supplement interaction

Pink Root + Diclofenac Sodium

Diclofenac Sodium brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pink Root and Diclofenac Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pink Root and Diclofenac Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac Sodium and Pink Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pink Root at all — not against Diclofenac Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pink Root safety at a glance

Pink Root overall Use caution Pink Root can be toxic in larger doses and has little modern safety data.
Pregnancy Likely Unsafe When used orally. For pink root to be effective, it must be used along with a purgative laxative. However, purgative laxative use is contraindicated during preg... Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding because safety has not been established.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac Sodium and Pink Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Diclofenac Sodium’s Own FDA Label Lists

This is not an interaction — none of it involves Pink Root. These are the most notable effects listed in the ADVERSE REACTIONS section of Diclofenac Sodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Loss of vision Worth acting on
  • Hearing loss Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Unsteadiness Worth acting on
  • Low blood sugar Worth acting on
  • A heart attack Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on

Showing the 10 most notable of 73 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed › Where a percentage is shown, it is the share of 155,962 voluntary FDA FAERS reports for Diclofenac Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pink Root’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pink Root side to compare — that is a limit of the record, not a statement that Pink Root has no side effects.

Special populations

Pink Root in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. For pink root to be effective, it must be used along with a purgative laxative. However, purgative laxative use is contraindicated during pregnancy. For this reason, pink root should not be used in pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pink Root or Diclofenac Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pink Root or Diclofenac Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac Sodium

This page covers Pink Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac Sodium page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 266 moderate · 35 minor.

From our pharmacist’s overview on the Diclofenac Sodium page

“Diclofenac (Voltaren), a daily mainstay for arthritis and joint pain, comes with a supplement list that calls for real vigilance. Of the 308 ingredients on file, 7 rate major, and roughly two hundred entries share a single theme: anything with blood-thinning activity adds to diclofenac's own bleeding risk, especially in the stomach.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac Sodium interaction page

One more smart check

Taking Pink Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Pink Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pink Root. Even though Pink Root itself has no known interaction with Diclofenac Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pink Root and Diclofenac Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pink Root
Steady interest

#971 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac Sodium
Top 10%

#269 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pink Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pink Root and Diclofenac Sodium records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pink Root

What is Pink Root?

  • Intestinal worms (anthelmintic)
  • Digestive complaints
  • Traditional folk remedy

Pink Root (Spigelia marilandica) is a North American plant that was historically used to expel intestinal worms. It contains potentially toxic compounds, has little modern safety or effectiveness data, and is rarely used today. We do not recommend self-treating with it; talk to a healthcare provider about safer, proven options.

Spigelia marilandica · Loganiaceae · Root and rhizome · Dried root, powder, tincture, tea (decoction)

An interaction check asks whether these two react with each other — it does not ask whether Pink Root is a good idea for someone in your situation. Here is what our Pink Root record says about it on its own.

Pink Root: dosing

There is no established, standardized safe dose of Pink Root for modern use. Historical doses are not considered reliable or safe by today's standards.Because of its potential toxicity, we do not recommend self-dosing.

From our Pink Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pink Root monograph & all interactions
Medication

About Diclofenac

What Is Diclofenac Used For?

Brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, Diclo SR, Voltarol, Acoflam, Defenac, Dicloflex, Diclovol, Diclozip, Fenactol, Flamrase, Volraman, Diclomax SR, Diclomax Retard, Motifene 75 mg, Voltarol 75 mg SR, Acoflam 75 SR, Defenac SR, Dexomon 75 SR, Dicloflex 75 SR, Diclovol SR, Fenactol 75 mg SR, Flamatak 75 MR, Flamrase SR, Flexotard MR 75, Rheumatac Retard 75, Rhumalgan CR, Slofenac SR, Volsaid Retard 75, Voltarol Retard, Acoflam Retard, Defenac Retard, Dexomon Retard 100, Dicloflex Retard, Diclovol Retard, Fenactol Retard 100 mg, Flamatak 100 MR, Volsaid Retard 100, Voltarol Ophtha Multidose, Voltarol Ophtha, Pennsaid, Voltaren Emulgel, Dyloject

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

Most-Reported Side Effects for Diclofenac Sodium

From FAERS, the FDA’s public side-effect reporting system (155,962 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,844 reports
Arthralgia 11,333 reports
Rash 10,855 reports
Rheumatoid arthritis 10,744 reports
Abdominal discomfort 9,636 reports
See full Diclofenac drug information
Keep checking

Other Drugs & Pink Root

Browse every other medication we’ve checked against Pink Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pink Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pink Root list.

See the full Pink Root interactions page
See every supplement checked against Diclofenac Sodium, ranked by severity
Evidence & sources

Pink Root References

The 1 references that drive our Pink Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pink Root and Diclofenac Sodium Together: Common Questions

Is it safe to take Pink Root with Diclofenac Sodium?
We do not list a known interaction between Pink Root and Diclofenac Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Diclofenac Sodium interact with any supplements?
Yes. Diclofenac Sodium has documented interactions with 308 supplements in our database — Pink Root is not one of them. The Diclofenac Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pink Root monograph Uses, safety profile, and every drug interaction in one place Diclofenac drug information The full plain-English guide to this medication Diclofenac Sodium supplement interactions Every supplement checked against Diclofenac Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac Sodium and Pink Root?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.