Drug & supplement interaction

Pleurisy Root + Conjugated Estrogens, Meprobamate

Conjugated Estrogens, Meprobamate brand names: PMB 200, PMB 400.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Pleurisy Root has a moderate interaction with Conjugated Estrogens, Meprobamate. Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Pleurisy Root and Conjugated Estrogens, Meprobamate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ESTROGENS

Why this applies to Conjugated Estrogens, Meprobamate

Conjugated Estrogens, Meprobamate falls under ESTROGENS — the group Pleurisy Root interacts with.

Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with PMB (which combines conjugated estrogens with meprobamate, a calming agent). The estrogen part is what we're focused on here. Pleurisy root contains plant compounds that may, in theory, interfere with how hormone therapy works in the body. This isn't a strong, proven interaction. It's based on pharmacology reasoning, not real-world studies, so I don't want you to panic.

The concern is mainly with large, concentrated supplement doses rather than tiny traditional amounts. If pleurisy root nudges your estrogen levels around, you might notice your usual symptom relief (like hot flashes) waver, or shifts in spotting. Honestly, given how little we know about pleurisy root and its own toxicity concerns, I'd loop in your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Pleurisy Root Also Interacts With Other Medications

Pleurisy Root has 1 major, 115 moderate known drug interactions in our database — the Conjugated Estrogens, Meprobamate one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 115 No known interaction 2,714 (incl. Conjugated Estrogens, Meprobamate)
Taking anything else?

Check Another of Your Medications Against Pleurisy Root

Covers the 2,830 medications we’ve checked against Pleurisy Root. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Conjugated Estrogens, Meprobamate

This page covers Pleurisy Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Conjugated Estrogens, Meprobamate page lists 187 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 152 moderate · 32 minor.

From our pharmacist’s overview on the Conjugated Estrogens, Meprobamate page

“If you take conjugated estrogens with meprobamate (PMB), a combination that pairs hormone replacement with a sedative, treat this list as a real safety check, not background noise. Three of the 187 entries on file rate major, and they pull in different directions.”

Reviewed by 2 · Jul 18, 2026

Open the Conjugated Estrogens, Meprobamate interaction page

How much people look this up

Where Pleurisy Root and Conjugated Estrogens, Meprobamate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pleurisy Root
Top half

#572 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Conjugated Estrogens, Meprobamate
Steady interest

#2,150 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Pleurisy Root

What is Pleurisy Root?

  • Respiratory congestion
  • Pleurisy and chest discomfort
  • Coughs and bronchitis
  • Promoting sweating during fevers
  • Loosening mucus

Pleurisy root is the dried root of Asclepias tuberosa (butterfly weed), a plant used in traditional North American and herbal medicine mainly for respiratory complaints. There is very little modern scientific evidence that it works for any condition, and it contains compounds that can be toxic, so caution is strongly advised. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Read the full Pleurisy Root monograph & all interactions
Keep checking

Other Drugs & Pleurisy Root

Browse every other medication we’ve checked against Pleurisy Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
115Moderate
0Minor
2,713No known interaction
1 Major 115 Moderate 2,713 No interaction
Major

1 interaction

Moderate

115 interactions

Showing 60 of 115 moderate interactions — see all 115 on the Pleurisy Root page.

No interaction 2,713 drugs checked — show the list

We also checked Pleurisy Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,713 medications checked with no known interaction — see the full Pleurisy Root list.

See the full Pleurisy Root interactions page
See every supplement checked against Conjugated Estrogens, Meprobamate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Pleurisy Root monograph › Uses, safety, and every drug interaction in one place Conjugated Estrogens, Meprobamate supplement interactions › Every supplement checked against Conjugated Estrogens, Meprobamate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Pleurisy Root and Conjugated Estrogens, Meprobamate Together: Common Questions

Can you take Pleurisy Root with Conjugated Estrogens, Meprobamate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Pleurisy Root and Conjugated Estrogens, Meprobamate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Conjugated Estrogens, Meprobamate and Pleurisy Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.