Drug & supplement interaction

Pleurisy Root + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pleurisy Root and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to.

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Interaction report

Pleurisy Root and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Pleurisy Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pleurisy Root safety at a glance

Pleurisy Root overall Use caution It contains potentially toxic compounds and has little safety data, so use cautiously and under guidance.
Pregnancy Avoid Traditionally used to stimulate the uterus and considered unsafe in pregnancy.
Breastfeeding Possibly Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Pleurisy Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tasimelteon

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tasimelteon is filed under 5 classifications — including cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates, cns depressants. Pleurisy Root has documented interactions with 3 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and estrogens (moderate) — and none of Tasimelteon’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pleurisy Root Does Interact With Other Medications

Pleurisy Root has 1 major, 116 moderate known drug interactions in our database — Tasimelteon isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 116 No known interaction 2,713 (incl. Tasimelteon)
Taking anything else?

Check Another of Your Medications Against Pleurisy Root

Covers the 2,830 medications we’ve checked against Pleurisy Root. Pick one to open its full report.

What to actually watch for

What Pleurisy Root Itself Has Been Linked To

This is not an interaction — nothing below involves Tasimelteon. It is the side-effect record for Pleurisy Root on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pleurisy Root, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness Worth acting on Additional detail

    “Orally, pleurisy root can cause gastrointestinal irritation, nausea, and vomiting (19). When consumed in large quantities, pleurisy root may cause digitalis-like poisoning symptoms (18). Acute digitalis poisoning symptoms include gastrointestinal upset, contracted pupils, blurred vision, strong slow pulse, nausea, vomiting, dizziness, excessive urination, fatigue, muscle weakness and tremors, stupor, confusion, convu…”

    Pleurisy Root · Natural Medicines adverse-effect record, reported in arrhythmia.

    5 sources cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    4. 159. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
    5. 501. De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI
  • A slow heartbeat Worth acting on Additional detail

    “Orally, consuming large quantities of pleurisy root may cause digitalis-like poisoning symptoms (18). Acute digitalis poisoning symptoms include strong slow pulse, atrial arrhythmias, bradycardia, AV block, cardiovascular shock, and death (6,159,501).”

    Pleurisy Root · Natural Medicines adverse-effect record, reported in arrhythmia.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 159. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
    4. 501. De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI
  • Confusion / Seizures Worth acting on Additional detail

    “Orally, consuming large quantities of pleurisy root may cause digitalis-like poisoning symptoms (18). Acute digitalis poisoning symptoms include dizziness, stupor, confusion, convulsions, and fatigue (6,159,501).”

    Pleurisy Root · Natural Medicines adverse-effect record, reported in fatigue.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 159. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
    4. 501. De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI
  • Blurred vision Additional detail

    “Orally, consuming large quantities of pleurisy root may cause digitalis-like poisoning symptoms (18). Acute digitalis poisoning symptoms include contracted pupils and blurred vision (6,159,501).”

    Pleurisy Root · Natural Medicines adverse-effect record, reported in poisoning.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 159. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
    4. 501. De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI
  • Stomach upset / Vomiting Additional detail

    “Orally, pleurisy root can cause gastrointestinal irritation, nausea, and vomiting (19). When consumed in large quantities, pleurisy root may cause digitalis-like poisoning symptoms (18). Acute digitalis poisoning symptoms include nausea, vomiting, and gastrointestinal upset (6,159,501).”

    Pleurisy Root · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    5 sources cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    4. 159. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
    5. 501. De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI
  • Tiredness / Dizziness Additional detail

    Recorded for Pleurisy Root in the same Natural Medicines adverse-effect record shown under Muscle weakness above.

  • A skin rash Additional detail

    “Topically, pleurisy root may cause dermatitis (19).”

    Pleurisy Root · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Pleurisy Root — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tasimelteon’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tasimelteon column appears here.

Special populations

Pleurisy Root in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Tasimelteon Products Have a Food Rule — Pleurisy Root Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Pleurisy Root included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Pleurisy Root to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. See the Tasimelteon drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Pleurisy Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

How much people look this up

Where Pleurisy Root and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pleurisy Root
Steady interest

#853 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Steady interest

#2,164 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pleurisy Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pleurisy Root and Tasimelteon records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pleurisy Root

What is Pleurisy Root?

  • Respiratory congestion
  • Pleurisy and chest discomfort
  • Coughs and bronchitis
  • Promoting sweating during fevers
  • Loosening mucus

Pleurisy root is the dried root of Asclepias tuberosa (butterfly weed), a plant used in traditional North American and herbal medicine mainly for respiratory complaints. There is very little modern scientific evidence that it works for any condition, and it contains compounds that can be toxic, so caution is strongly advised. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Asclepias tuberosa · Apocynaceae · Dried root · Tea, tincture, capsules, dried root

An interaction check asks whether these two react with each other — it does not ask whether Pleurisy Root is a good idea for someone in your situation. Here is what our Pleurisy Root record says about it on its own.

Pleurisy Root: dosing

There is no well-established or standardized dose for pleurisy root, and the strength of products can vary widely. Because of its potential toxicity, more is not better and self-dosing can be risky.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Pleurisy Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pleurisy Root monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Pleurisy Root

Browse every other medication we’ve checked against Pleurisy Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
116Moderate
0Minor
2,712No known interaction
1 Major 116 Moderate 2,712 No interaction
Major

1 interaction

Moderate

116 interactions

Showing 60 of 116 moderate interactions — see all 116 on the Pleurisy Root page.

No interaction 2,712 drugs checked — show the list

We also checked Pleurisy Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,712 medications checked with no known interaction — see the full Pleurisy Root list.

See the full Pleurisy Root interactions page
See every supplement checked against Tasimelteon, ranked by severity
Evidence & sources

Pleurisy Root References

The 7 references that drive our Pleurisy Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
  7. De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pleurisy Root and Tasimelteon Together: Common Questions

Is it safe to take Pleurisy Root with Tasimelteon?
We do not list a known interaction between Pleurisy Root and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Pleurisy Root and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Pleurisy Root to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Pleurisy Root and Tasimelteon combination checked?
Interactions in our licensed database are recorded against drug classes. Tasimelteon is filed under 5 classifications, and Pleurisy Root has documented interactions with 3 drug classes — none of Tasimelteon's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pleurisy Root interact with any other medications?
Yes. Pleurisy Root has 117 documented drug interactions in our database — Tasimelteon is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Pleurisy Root is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pleurisy Root monograph Uses, safety profile, and every drug interaction in one place Tasimelteon drug information The full plain-English guide to this medication Tasimelteon supplement interactions Every supplement checked against Tasimelteon, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tasimelteon and Pleurisy Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.