Drug & supplement interaction

Plum + Amiloride, Hydrochlorothiazide

Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Plum and Amiloride, Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Amiloride, Hydrochlorothiazide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Plum and Amiloride, Hydrochlorothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amiloride, Hydrochlorothiazide and Plum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Plum safety at a glance

Plum overall Generally safe Plums and prunes are widely eaten as food and are generally safe in normal amounts.
Pregnancy Use caution Plum as a food is generally fine, but concentrated supplements are not well studied in pregnancy.
Breastfeeding Use caution Eating plums is generally considered fine, but concentrated supplement forms lack safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amiloride, Hydrochlorothiazide and Plum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Amiloride, Hydrochlorothiazide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amiloride, Hydrochlorothiazide is filed under 10 classifications — including potassium-sparing diuretics, thiazide diuretics, diuretic drugs. Plum has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Amiloride, Hydrochlorothiazide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Plum Does Interact With Other Medications

Plum has 122 moderate known drug interactions in our database — Amiloride, Hydrochlorothiazide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Amiloride, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against Plum

Covers the 2,830 medications we’ve checked against Plum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Plum and Amiloride, Hydrochlorothiazide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Plum

    “Orally, plum seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Gastrointestinal effects, including flatulence and diarrhea.

    Serious Adverse Effects (Rare):

    Orally: Allergic reactions. Consumption of dried plums or plum pits has been reported to cause bowel obstruction and esophageal perforation.”

    Plum · Natural Medicines adverse-effect record, reported in diarrhea.

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

  • Bloating or gas / Diarrhea Additional detail

    Plum

    “Orally, plum has been reported to cause gastrointestinal issues, including flatulence and diarrhea.

    In one case report, small bowel obstruction with impaction in the terminal ileum occurred in a 10-month old infant who consumed a dried plum. This was likely due to the infant being unable to properly chew the plum.

    Consumption of plum pits has also caused serious gastrointestinal adverse effects.”

    Plum · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 95272. Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
    2. 95276. Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
    3. 95285. Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed
    4. 95293. Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
    5. 95300. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
    6. 95296. Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

Reported for Plum but not commonly for Amiloride, Hydrochlorothiazide: a bowel blockage.

Effects for Amiloride, Hydrochlorothiazide come from the ADVERSE REACTIONS section of its FDA label; effects for Plum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Amiloride, Hydrochlorothiazide Products Have a Food Rule — Plum Should Not Break It

At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Plum on an empty stomach out of habit, keep them separate — and take Amiloride, Hydrochlorothiazide with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Amiloride, Hydrochlorothiazide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Amiloride hydrochloride and hydrochlorothiazide tablets should be administered with food.

From the Dosage and Administration section of the FDA label we read for Amiloride, Hydrochlorothiazide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Amiloride, Hydrochlorothiazide Is Prescribed For, and What Plum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Amiloride, Hydrochlorothiazide is a prescription medicine with approved uses on its FDA label. Plum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Amiloride, Hydrochlorothiazide is prescribed for: Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems. The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.

Plum has been studied for:

  • Hypertension studied, not established Plum has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Plum for hypertension

    It is unclear if oral plum is beneficial for hypertension.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amiloride, Hydrochlorothiazide on your own; if you are taking Plum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Amiloride, Hydrochlorothiazide

This page covers Plum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride, Hydrochlorothiazide page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

From our pharmacist’s overview on the Amiloride, Hydrochlorothiazide page

“The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Amiloride, Hydrochlorothiazide interaction page

One more smart check

Taking Plum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,682 real supplement products containing Plum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Plum. Even though Plum itself has no known interaction with Amiloride, Hydrochlorothiazide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Plum and Amiloride, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Plum
Top 25%

#193 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amiloride, Hydrochlorothiazide
Top 25%

#562 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Plum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Plum and Amiloride, Hydrochlorothiazide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Plum

What is Plum?

  • Constipation
  • Digestive health
  • Bone health support
  • Antioxidant source
  • General nutrition

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as food, but eating large amounts can cause gas, bloating, or loose stools. Talk to your pharmacist or doctor before using concentrated supplements, especially if you have a medical condition.

Prunus domestica · Rosaceae · Fruit (fresh and dried, also called prunes); juice · Fresh fruit, dried plums (prunes), juice, powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Plum is a good idea for someone in your situation. Here is what our Plum record says about it on its own.

Plum: dosing

There is no official standardized dose for plum. As a food, people often eat a small serving of dried plums or drink a small glass of plum juice to help with constipation, then adjust based on how their body responds.For supplements, powders, or capsules, follow the directions on the product label, since strength varies between products.

From our Plum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Plum monograph & all interactions
Medication

About Amiloride and Hydrochlorothiazide

What Is Amiloride and Hydrochlorothiazide Used For?

Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co

Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems.

The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.

See full Amiloride and Hydrochlorothiazide drug information
Keep checking

Other Drugs & Plum

Browse every other medication we’ve checked against Plum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Plum page.

No interaction 2,707 drugs checked — show the list

We also checked Plum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Plum list.

See the full Plum interactions page
See every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity
Evidence & sources

Plum References

The 10 references that drive our Plum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
  2. Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
  3. Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed
  4. Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
  5. Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed
  6. Jain M, Pielage P, De-Ryke R. Plum stones: an unusual cause of ileostomy obstruction demonstrated by sonography. J Clin Ultrasound. 1998;26(8):416-7. DOI
  7. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
  8. Santhakumar AB, Kundur AR, Fanning K, Netzel M, Stanley R, Singh I. Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. J. Functional Foods. 2015;12:11-22. DOI
  9. Santhakumar AB, Kundur AR, Sabapathy S, Stanley R, Singh I. The potential of anthocyanin-rich Queen Garnet plum juice supplementation in alleviating thrombotic risk under induced oxidative stress conditions. J. Functional Foods. 2015;14:747-57. DOI
  10. Johnson MC, Fisher JK. Plum pit ileus: a case report. Mo Med. 1991;88(10):696-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Plum and Amiloride, Hydrochlorothiazide Together: Common Questions

Is it safe to take Plum with Amiloride, Hydrochlorothiazide?
We do not list a known interaction between Plum and Amiloride, Hydrochlorothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Plum and Amiloride, Hydrochlorothiazide have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Plum and Amiloride, Hydrochlorothiazide at the same time of day?
At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Plum on an empty stomach out of habit, keep them separate and take Amiloride, Hydrochlorothiazide with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Amiloride, Hydrochlorothiazide products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Plum and Amiloride, Hydrochlorothiazide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Plum in each. That is a conversation for your prescriber, especially if Amiloride, Hydrochlorothiazide is being adjusted to a target.
How was the Plum and Amiloride, Hydrochlorothiazide combination checked?
Interactions in our licensed database are recorded against drug classes. Amiloride, Hydrochlorothiazide is filed under 10 classifications, and Plum has documented interactions with 1 drug class — none of Amiloride, Hydrochlorothiazide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Plum interact with any other medications?
Yes. Plum has 122 documented drug interactions in our database — Amiloride, Hydrochlorothiazide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Amiloride, Hydrochlorothiazide interact with any supplements?
Yes. Amiloride, Hydrochlorothiazide has documented interactions with 236 supplements in our database — Plum is not one of them. The Amiloride, Hydrochlorothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Plum monograph Uses, safety profile, and every drug interaction in one place Amiloride and Hydrochlorothiazide drug information The full plain-English guide to this medication Amiloride, Hydrochlorothiazide supplement interactions Every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amiloride, Hydrochlorothiazide and Plum?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.