Medication interaction hub

What Supplements Interact with Amiloride, Hydrochlorothiazide?

Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co. Every interaction below applies to the brands too.

236 Interactions 10 Major 199 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amiloride, Hydrochlorothiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amiloride, Hydrochlorothiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim. Ten of the 236 ingredients on file are rated major, and most of the 199 moderate entries either push blood pressure lower, work against the drug, or shift the fluid and potassium balance it is built to manage.

Potassium is the one to understand first. The amiloride half of this pill holds potassium in, so supplementing it risks levels climbing too high, while a few herbs compound potassium loss instead. Larger amounts of calcium raise the odds of high blood calcium and kidney trouble with the thiazide half, activated charcoal can soak up the dose itself, and about twenty ingredients add sun sensitivity to a drug that already causes it. Start with the ten major entries.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 199 Minor 27 No known interaction 1,216

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amiloride, Hydrochlorothiazide: Top Interactions at a Glance

The Amiloride, Hydrochlorothiazide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 236 interacting ingredients — plus 1,216 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amiloride, Hydrochlorothiazide Combinations Today

The Amiloride, Hydrochlorothiazide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Calcium + Amiloride, Hydrochlorothiazidei

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Read the full interaction Moderate Likelihood Probable Magnesium + Amiloride, Hydrochlorothiazidei

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.

Read the full interaction Moderate Likelihood Possible N-acetyl Cysteine (nac) + Amiloride, Hydrochlorothiazidei

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable L-arginine + Amiloride, Hydrochlorothiazidei

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Docosahexaenoic Acid (dha) + Amiloride, Hydrochlorothiazidei

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Butternut + Amiloride, Hydrochlorothiazidei

Butternut has stimulant laxative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Amiloride, Hydrochlorothiazide

All 1,452 ingredients in our database, ranked by severity — 236 with a Amiloride, Hydrochlorothiazide interaction on file and 1,216 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amiloride, Hydrochlorothiazide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Amiloride, Hydrochlorothiazide answer

Can you take Magnesium with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.

Full Magnesium + Amiloride, Hydrochlorothiazide answer

Can you take N-acetyl Cysteine (nac) with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Full N-acetyl Cysteine (nac) + Amiloride, Hydrochlorothiazide answer

Can you take L-arginine with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Full L-arginine + Amiloride, Hydrochlorothiazide answer

Can you take Docosahexaenoic Acid (dha) with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Amiloride, Hydrochlorothiazide answer

Can you take Mountain Ash with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Amiloride, Hydrochlorothiazide answer

Can you take Nattokinase with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Full Nattokinase + Amiloride, Hydrochlorothiazide answer

Can you take Niacin with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Amiloride, Hydrochlorothiazide answer

Can you take Noni with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.

Full Noni + Amiloride, Hydrochlorothiazide answer

Can you take Octopamine with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.

Full Octopamine + Amiloride, Hydrochlorothiazide answer

Can you take Oolong Tea with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.

Full Oolong Tea + Amiloride, Hydrochlorothiazide answer

Can you take Oregon Grape with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.

Full Oregon Grape + Amiloride, Hydrochlorothiazide answer

Can you take Parsley with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Full Parsley + Amiloride, Hydrochlorothiazide answer

Can you take Pheasant's Eye with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Pheasant's Eye + Amiloride, Hydrochlorothiazide answer

Can you take Phellodendron with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might have additive effects with antihypertensive drugs.

Full Phellodendron + Amiloride, Hydrochlorothiazide answer

Can you take Pleurisy Root with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...

Full Pleurisy Root + Amiloride, Hydrochlorothiazide answer

Can you take Pomegranate with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Amiloride, Hydrochlorothiazide answer

Can you take Quassia with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of quassia might compound diuretic-induced potassium loss.

Full Quassia + Amiloride, Hydrochlorothiazide answer

Can you take Quercetin with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.

Full Quercetin + Amiloride, Hydrochlorothiazide answer

Can you take Rauvolfia Vomitoria with Amiloride, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.

Full Rauvolfia Vomitoria + Amiloride, Hydrochlorothiazide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amiloride, Hydrochlorothiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amiloride, Hydrochlorothiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amiloride, Hydrochlorothiazide sits in 10 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Potassium-Sparing Diuretics 8 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

8 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Amiloride, Hydrochlorothiazide through this category.

Amiloride (Midamor) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Amiloride, Hydrochlorothiazide through this category.

About Amiloride, Hydrochlorothiazide

Amiloride and hydrochlorothiazide is a combination diuretic (water pill) used to treat high blood pressure and congestive heart failure in people who need help keeping their potassium levels from dropping too low.

Generic name: Amiloride, Hydrochlorothiazide  ·  Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.

See the full Amiloride and Hydrochlorothiazide drug information

Related: does Amiloride, Hydrochlorothiazide deplete any nutrients?

Amiloride, Hydrochlorothiazide has 36 reported nutrient associations in the research literature — see the Amiloride, Hydrochlorothiazide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amiloride, Hydrochlorothiazide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amiloride, Hydrochlorothiazide.

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Pharmacist Counseling Corner

Amiloride, Hydrochlorothiazide & Supplements: Common Questions

What supplements interact with Amiloride, Hydrochlorothiazide?
More than you might expect — 236 in total, though they are far from equal: 10 are rated major, 199 moderate, and 27 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Amiloride, Hydrochlorothiazide supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Amiloride, Hydrochlorothiazide?
Usually yes — most people on Amiloride, Hydrochlorothiazide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Moduretic have the same supplement interactions as Amiloride, Hydrochlorothiazide?
Yes — Moduretic, Amilzide, Moduret 25, Amil-Co all contain Amiloride, Hydrochlorothiazide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amiloride, Hydrochlorothiazide deplete any vitamins or nutrients?
It might — Amiloride, Hydrochlorothiazide has 36 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amiloride, Hydrochlorothiazide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amiloride, Hydrochlorothiazide and my other medications?
This page covers Amiloride, Hydrochlorothiazide against supplements and herbal ingredients. Checking Amiloride, Hydrochlorothiazide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Amiloride and Hydrochlorothiazide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.