Cassia Cinnamon + Amiloride, Hydrochlorothiazide
Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.
We found no known interaction between Cassia Cinnamon and Amiloride, Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Amiloride, Hydrochlorothiazide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Cassia Cinnamon and Amiloride, Hydrochlorothiazide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Amiloride, Hydrochlorothiazide and Cassia Cinnamon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cassia Cinnamon safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Amiloride, Hydrochlorothiazide
Interactions in our licensed database are recorded against drug classes, not just single drug names. Amiloride, Hydrochlorothiazide is filed under 10 classifications — including potassium-sparing diuretics, thiazide diuretics, diuretic drugs. Cassia Cinnamon has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and hepatotoxic drugs (moderate) — and none of Amiloride, Hydrochlorothiazide’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Cassia Cinnamon Does Interact With Other Medications
Cassia Cinnamon has 442 moderate known drug interactions in our database — Amiloride, Hydrochlorothiazide isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cassia Cinnamon
We haven’t checked that one against Cassia Cinnamon yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cassia Cinnamon. Pick one to open its full report.
Cassia Cinnamon in Pregnancy & Breastfeeding
When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of cassia cinnamon when used in medicinal amounts during pregnancy and breast-feeding. Stay on the safe side and stick to food amounts.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Amiloride, Hydrochlorothiazide Products Have a Food Rule — Cassia Cinnamon Should Not Break It
At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Cassia Cinnamon on an empty stomach out of habit, keep them separate — and take Amiloride, Hydrochlorothiazide with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Amiloride, Hydrochlorothiazide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
DOSAGE AND ADMINISTRATION Amiloride hydrochloride and hydrochlorothiazide tablets should be administered with food.
From the Dosage and Administration section of the FDA label we read for Amiloride, Hydrochlorothiazide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Amiloride, Hydrochlorothiazide Is Prescribed For, and What Cassia Cinnamon Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Amiloride, Hydrochlorothiazide is a prescription medicine with approved uses on its FDA label. Cassia Cinnamon is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Amiloride, Hydrochlorothiazide is prescribed for: Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems. The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.
Cassia Cinnamon has been studied for:
-
Stroke studied, not established Cassia Cinnamon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Cassia Cinnamon for stroke
It is unclear if oral cassia cinnamon is beneficial for stroke prevention.
-
Hypertension studied, not established Cassia Cinnamon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Cassia Cinnamon for hypertension
Although there has been interest in using oral cassia cinnamon for hypertension, there is insufficient reliable information about the clinical effects of cassia cinnamon for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amiloride, Hydrochlorothiazide on your own; if you are taking Cassia Cinnamon for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Amiloride, Hydrochlorothiazide
This page covers Cassia Cinnamon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride, Hydrochlorothiazide page lists 236 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).
By severity: 10 major · 199 moderate · 27 minor.
From our pharmacist’s overview on the Amiloride, Hydrochlorothiazide page
“The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim.”
Reviewed by 2 · Jul 18, 2026
Taking Cassia Cinnamon as Part of a Dietary Supplement Product? Check It for Interactions
We hold 3,249 real supplement products containing Cassia Cinnamon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cassia Cinnamon. Even though Cassia Cinnamon itself has no known interaction with Amiloride, Hydrochlorothiazide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Cassia Cinnamon and Amiloride, Hydrochlorothiazide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#77 of 1,452 supplements looked up here in the last 7 days
#304 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cassia Cinnamon reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cassia Cinnamon and Amiloride, Hydrochlorothiazide records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cassia Cinnamon
What is Cassia Cinnamon?
- Blood sugar support
- Digestive upset
- Antioxidant support
- Flavoring and culinary use
- Antimicrobial
Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed and far from proven, and because cassia is naturally high in coumarin, taking large amounts regularly may stress the liver. Use food amounts freely, but talk with a pharmacist or doctor before using high-dose supplements.
Cinnamomum cassia · Lauraceae · Inner bark (and young twigs) · Ground spice, sticks (quills), capsules, tea, extracts, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Cassia Cinnamon is a good idea for someone in your situation. Here is what our Cassia Cinnamon record says about it on its own.
Cassia Cinnamon: dosing
There is no official or well-established medicinal dose for cassia cinnamon. Studies have used a range of amounts, but the results are not consistent enough to recommend a specific dose.If you choose to use a supplement, follow the directions on the product label and do not exceed them. Because of the coumarin content, it is wise to avoid taking large amounts of cassia cinnamon every day for long periods.
From our Cassia Cinnamon monograph — the full record covers uses, side effects and every documented interaction.
About Amiloride and Hydrochlorothiazide
What Is Amiloride and Hydrochlorothiazide Used For?
Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co
Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems.
The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.
Other Drugs & Cassia Cinnamon
Browse every other medication we’ve checked against Cassia Cinnamon — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
442 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Insulin (rdna) ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Quinidine ›
- Cyclosporine ›
- Glyburide ›
- Insulin (pork) ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Phenytoin ›
- Allopurinol ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Insulin (human) ›
- Acetaminophen ›
- Methotrexate ›
- Nitrofurantoin ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Acarbose ›
- Dapsone ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Insulin Glargine ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
- Naltrexone ›
- Riluzole ›
- Semaglutide ›
- Valproic Acid ›
- Abiraterone Acetate ›
- Acebutolol ›
- Ambrisentan ›
- Amiodarone ›
- Azathioprine ›
- Chlorpropamide ›
- Choline Magnesium Trisalicylate ›
- Cyclophosphamide ›
- Daclizumab ›
- Dantrolene ›
- Deferasirox ›
- Diclofenac Epolamine ›
- Exenatide ›
- Fingolimod ›
- Fluconazole ›
- Fluvastatin ›
Showing 60 of 442 moderate interactions — see all 442 on the Cassia Cinnamon page.
No interaction 2,387 drugs checked — show the list
We also checked Cassia Cinnamon against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Finasteride ›
- Estrogen ›
Showing the 60 most looked-up of 2,387 medications checked with no known interaction — see the full Cassia Cinnamon list.
Cassia Cinnamon References
The 20 references that drive our Cassia Cinnamon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
- De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
- Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
- Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
- Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
- Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
- Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
- Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
- Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
- Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
- Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
- Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
- Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
- Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
- Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Amiloride, Hydrochlorothiazide Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Amiloride, Hydrochlorothiazide as a medicine that can lower these. This is not an interaction with Cassia Cinnamon — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Amiloride, Hydrochlorothiazide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cassia Cinnamon and Amiloride, Hydrochlorothiazide Together: Common Questions
Is it safe to take Cassia Cinnamon with Amiloride, Hydrochlorothiazide?
Do Cassia Cinnamon and Amiloride, Hydrochlorothiazide have any of the same side effects?
Should I take Cassia Cinnamon and Amiloride, Hydrochlorothiazide at the same time of day?
Are Cassia Cinnamon and Amiloride, Hydrochlorothiazide used for the same thing?
How was the Cassia Cinnamon and Amiloride, Hydrochlorothiazide combination checked?
Does Cassia Cinnamon interact with any other medications?
Does Amiloride, Hydrochlorothiazide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Amiloride, Hydrochlorothiazide and Cassia Cinnamon?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.