Choline + Amiloride, Hydrochlorothiazide
Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.
We found no known interaction between Choline and Amiloride, Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Amiloride, Hydrochlorothiazide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Choline and Amiloride, Hydrochlorothiazide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Amiloride, Hydrochlorothiazide and Choline in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Choline safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Amiloride, Hydrochlorothiazide
Interactions in our licensed database are recorded against drug classes, not just single drug names. Amiloride, Hydrochlorothiazide is filed under 10 classifications — including potassium-sparing diuretics, thiazide diuretics, diuretic drugs. Choline has documented interactions with 1 drug class — the most serious being atropine (minor) — and none of Amiloride, Hydrochlorothiazide’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Choline Does Interact With Other Medications
Choline has 16 minor known drug interactions in our database — Amiloride, Hydrochlorothiazide isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Choline
We haven’t checked that one against Choline yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Choline. Pick one to open its full report.
Choline in Pregnancy & Breastfeeding
When used orally and appropriately. Choline is safe when taken in doses below the tolerable upper intake level (UL), which is 3 grams daily during pregnancy and lactation in those up to 18 years of age and 3.5 grams daily for those 19 years and older. There is insufficient reliable information available about the safety of choline used in higher doses during pregnancy and lactation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Amiloride, Hydrochlorothiazide Products Have a Food Rule — Choline Should Not Break It
At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Choline on an empty stomach out of habit, keep them separate — and take Amiloride, Hydrochlorothiazide with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Amiloride, Hydrochlorothiazide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
DOSAGE AND ADMINISTRATION Amiloride hydrochloride and hydrochlorothiazide tablets should be administered with food.
From the Dosage and Administration section of the FDA label we read for Amiloride, Hydrochlorothiazide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Amiloride, Hydrochlorothiazide Is Prescribed For, and What Choline Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Amiloride, Hydrochlorothiazide is a prescription medicine with approved uses on its FDA label. Choline is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Amiloride, Hydrochlorothiazide is prescribed for: Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems. The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.
Choline has been studied for:
-
Hypertension studied, not established Choline has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Choline for hypertension
It is unclear if oral choline is beneficial for the prevention or treatment of hypertension.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amiloride, Hydrochlorothiazide on your own; if you are taking Choline for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Choline or Amiloride, Hydrochlorothiazide
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Choline or Amiloride, Hydrochlorothiazide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Amiloride, Hydrochlorothiazide
This page covers Choline only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride, Hydrochlorothiazide page lists 236 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).
By severity: 10 major · 199 moderate · 27 minor.
From our pharmacist’s overview on the Amiloride, Hydrochlorothiazide page
“The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim.”
Reviewed by 2 · Jul 18, 2026
Taking Choline as Part of a Dietary Supplement Product? Check It for Interactions
We hold 11,172 real supplement products containing Choline, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Choline. Even though Choline itself has no known interaction with Amiloride, Hydrochlorothiazide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Choline and Amiloride, Hydrochlorothiazide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#21 of 1,452 supplements looked up here in the last 7 days
#514 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Choline reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Choline and Amiloride, Hydrochlorothiazide records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Choline
What is Choline?
- Liver health and fatty liver
- Brain and memory support
- Prenatal nutrition and fetal development
- General nutritional supplementation
- Sports performance
Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help people who are deficient or who have higher needs (such as during pregnancy), but they are not proven cure-alls and very high doses can cause side effects. Check with your pharmacist or doctor before starting a supplement.
Not applicable (an essential nutrient found in foods and made in the body) · Capsules, tablets, softgels, and powders; common forms include choline bitartrate, choline chloride, phosphatidylcholine, alpha-GPC, and CDP-choline (citicoline)
An interaction check asks whether these two react with each other — it does not ask whether Choline is a good idea for someone in your situation. Here is what our Choline record says about it on its own.
Choline: dosing
There is no single "treatment" dose of choline that works for everyone, and the right amount depends on your age, sex, life stage, and diet. Health authorities have set recommended adequate intake levels for daily choline as well as a daily upper limit, but these are general nutrition guides rather than doses for treating any condition.Supplements come in different strengths and forms, and the amount of actual choline varies by form.
From our Choline monograph — the full record covers uses, side effects and every documented interaction.
About Amiloride and Hydrochlorothiazide
What Is Amiloride and Hydrochlorothiazide Used For?
Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co
Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems.
The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.
Other Drugs & Choline
Browse every other medication we’ve checked against Choline — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
16 interactions
- Atropine Sulfate ›
- Atropine ›
- Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine ›
- Atropine, Hyoscyamine, Scopolamine, Phenobarbital ›
- Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate ›
- Atropine, Diphenoxylate ›
- Atropine, Hyoscyamine, Phenobarbital, Scopolamine ›
- Belladonna Alkaloids, Phenobarbital ›
- Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl ›
- Atropine, Difenoxin ›
- Atropine, Hyoscyamine, Phenobarbital ›
- Atropine, Hyoscyamine, Scopolamine ›
- Atropine, Meperidine ›
- Atropine, Morphine Sulfate ›
- Atropine, Phenobarbital ›
- Edrophonium, Atropine ›
No interaction 2,813 drugs checked — show the list
We also checked Choline against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Acyclovir ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Choline list.
Choline References
The 14 references that drive our Choline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
- Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
- Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
- Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
- Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
- Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
- Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
- Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
- Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
- Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
- Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
- Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
- Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Amiloride, Hydrochlorothiazide Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Amiloride, Hydrochlorothiazide as a medicine that can lower these. This is not an interaction with Choline — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Amiloride, Hydrochlorothiazide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Choline and Amiloride, Hydrochlorothiazide Together: Common Questions
Is it safe to take Choline with Amiloride, Hydrochlorothiazide?
Do Choline and Amiloride, Hydrochlorothiazide have any of the same side effects?
Should I take Choline and Amiloride, Hydrochlorothiazide at the same time of day?
Are Choline and Amiloride, Hydrochlorothiazide used for the same thing?
How was the Choline and Amiloride, Hydrochlorothiazide combination checked?
Does Choline interact with any other medications?
Does Amiloride, Hydrochlorothiazide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.