Drug & supplement interaction

Nux Vomica + Amiloride, Hydrochlorothiazide

Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Nux Vomica and Amiloride, Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Amiloride, Hydrochlorothiazide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Nux Vomica and Amiloride, Hydrochlorothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amiloride, Hydrochlorothiazide and Nux Vomica in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Nux Vomica at all — not against Amiloride, Hydrochlorothiazide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nux Vomica safety at a glance

Nux Vomica overall Avoid It contains strychnine, a highly toxic poison, and concentrated forms can be fatal.
Pregnancy Avoid Avoid during pregnancy because of the risk of poisoning and lack of safety data.
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amiloride, Hydrochlorothiazide and Nux Vomica? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Nux Vomica and Amiloride, Hydrochlorothiazide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems / Shortness of breath Worth acting on Additional detail

    Nux Vomica

    “Orally, 30-50 mg nux vomica (5 mg strychnine) can cause restlessness, feelings of anxiety, heightening of sense perception, enhanced reflexes, equilibrium disorders, painful neck and back stiffness, followed later by twitching, tonic spasms of jaw and neck muscles, painful convulsions of the entire body triggered by visual or tactile stimulation with possible opisthotonos, muscle hypertonicity and agitation.”

    Nux Vomica · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
    3. 65345. Katz, J., Prescott, K., and Woolf, A. D. Strychnine poisoning from a Cambodian traditional remedy. Am J Emerg.Med 1996;14(5):475-477. PubMed
    4. 13. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
    5. 505. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
    6. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Nux Vomica

    Recorded for Nux Vomica in the same Natural Medicines adverse-effect record shown under Kidney problems / Shortness of breath above.

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Nux Vomica

    Recorded for Nux Vomica in the same Natural Medicines adverse-effect record shown under Kidney problems / Shortness of breath above.

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

  • Dizziness Additional detail

    Nux Vomica

    Recorded for Nux Vomica in the same Natural Medicines adverse-effect record shown under Kidney problems / Shortness of breath above.

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

Reported for Nux Vomica but not commonly for Amiloride, Hydrochlorothiazide: severe muscle breakdown, seizures and pain in an arm or leg.

Effects for Amiloride, Hydrochlorothiazide come from the ADVERSE REACTIONS section of its FDA label; effects for Nux Vomica come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Nux Vomica in Pregnancy & Breastfeeding

Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Amiloride, Hydrochlorothiazide Products Have a Food Rule — Nux Vomica Should Not Break It

At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Nux Vomica on an empty stomach out of habit, keep them separate — and take Amiloride, Hydrochlorothiazide with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Amiloride, Hydrochlorothiazide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Amiloride hydrochloride and hydrochlorothiazide tablets should be administered with food.

From the Dosage and Administration section of the FDA label we read for Amiloride, Hydrochlorothiazide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Amiloride, Hydrochlorothiazide

This page covers Nux Vomica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride, Hydrochlorothiazide page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

From our pharmacist’s overview on the Amiloride, Hydrochlorothiazide page

“The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Amiloride, Hydrochlorothiazide interaction page

One more smart check

Taking Nux Vomica as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Nux Vomica, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nux Vomica. Even though Nux Vomica itself has no known interaction with Amiloride, Hydrochlorothiazide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Nux Vomica and Amiloride, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nux Vomica
Steady interest

#1,265 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amiloride, Hydrochlorothiazide
Top 10%

#230 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nux Vomica reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Nux Vomica and Amiloride, Hydrochlorothiazide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Nux Vomica

What is Nux Vomica?

  • Digestive upset and indigestion
  • Nausea and constipation
  • Hangover symptoms
  • Sleep problems and irritability
  • General 'detox' or tonic use in traditional medicine

Nux vomica comes from a tree seed that contains strychnine, a powerful and potentially deadly poison. It is mostly sold today in extremely diluted homeopathic forms, and there is no good scientific evidence that it treats any condition. Because even small amounts of the raw or concentrated material can cause severe poisoning, it is best avoided unless you are using a properly prepared product under professional guidance.

Strychnos nux-vomica · Loganiaceae · Dried seeds (and sometimes bark) · Homeopathic pellets and liquids, highly diluted preparations

An interaction check asks whether these two react with each other — it does not ask whether Nux Vomica is a good idea for someone in your situation. Here is what our Nux Vomica record says about it on its own.

Nux Vomica: dosing

There is no established safe dose of nux vomica as a dietary supplement, and we do not recommend using raw or concentrated forms at all. The difference between a traditional 'small' amount and a toxic amount can be very small.Homeopathic products list their own dilutions on the label (such as 6C or 30C). If you choose to use one, follow the product label exactly and do not exceed it.

From our Nux Vomica monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nux Vomica monograph & all interactions
Medication

About Amiloride and Hydrochlorothiazide

What Is Amiloride and Hydrochlorothiazide Used For?

Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co

Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems.

The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.

See full Amiloride and Hydrochlorothiazide drug information
Keep checking

Other Drugs & Nux Vomica

Browse every other medication we’ve checked against Nux Vomica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Nux Vomica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Nux Vomica list.

See the full Nux Vomica interactions page
See every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity
Evidence & sources

Nux Vomica References

The 7 references that drive our Nux Vomica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  6. Katz, J., Prescott, K., and Woolf, A. D. Strychnine poisoning from a Cambodian traditional remedy. Am J Emerg.Med 1996;14(5):475-477. PubMed
  7. Dai TY, Chen CC, Hong LL, et al. Effect evaluation of strychnos nux-vomica L. with integrative methods for bortezomib-induced peripheral neuropathy in multiple myeloma patients: A self-controlled clinical trial. Chin J Integr Med. 2020 May 16. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nux Vomica and Amiloride, Hydrochlorothiazide Together: Common Questions

Is it safe to take Nux Vomica with Amiloride, Hydrochlorothiazide?
We do not list a known interaction between Nux Vomica and Amiloride, Hydrochlorothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Nux Vomica and Amiloride, Hydrochlorothiazide have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Nux Vomica and Amiloride, Hydrochlorothiazide at the same time of day?
At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Nux Vomica on an empty stomach out of habit, keep them separate and take Amiloride, Hydrochlorothiazide with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Amiloride, Hydrochlorothiazide products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Amiloride, Hydrochlorothiazide interact with any supplements?
Yes. Amiloride, Hydrochlorothiazide has documented interactions with 236 supplements in our database — Nux Vomica is not one of them. The Amiloride, Hydrochlorothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nux Vomica monograph Uses, safety profile, and every drug interaction in one place Amiloride and Hydrochlorothiazide drug information The full plain-English guide to this medication Amiloride, Hydrochlorothiazide supplement interactions Every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amiloride, Hydrochlorothiazide and Nux Vomica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.