Aristolochia - Amiloride, Hydrochlorothiazide Interaction
Herbal: Aristolochia
Also Known As: Aristolochia auricularia, Birthwort, Guan Mu Tong, Guang Fang Ji, Long Birthwort, Pelican Flower, Poison de Terre, Pomerasse, Ratelaine, Rateline, Red River Snakeroot, Sangree Root, Sangrel, Sarrasine, Serpentaire, Snakeroot, Snakeweed, Virginia Serpentary
Drug: Amiloride, Hydrochlorothiazide
Brand names:
Moduretic, Amilzide, Moduret 25, Amil-Co
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Amiloride, Hydrochlorothiazide is classified as belonging to the following category: Nephrotoxic Drugs
Aristolochia is nephrotoxic. There are numerous cases of nephropathy and renal failure associated with aristolochia use. Theoretically, combining aristolochia with potentially nephrotoxic drugs might have additive adverse effects on kidney function. However, this interaction has not yet been reported in humans. Close monitoring of renal function in patients taking aristolochia with nephrotoxic drugs may be warranted.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Aristolochia Overview
Aristolochia is a genus of plants that includes over 500 species, many of which are known for their tubular flowers. These plants are native to a wide range of regions, including tropical and subtropical areas of the Americas, Asia, and Africa.
Aristolochia species are most commonly cultivated for their ornamental value but also have a long history of use in traditional Chinese medicine as an aphrodisiac, anticonvulsant, immune stimulant, to promote menstruation, and to treat snakebites.
However, some Aristolochia species contain aristolochic acid, a toxic compound that can cause serious health problems when ingested. The FDA (Food and Drug Administration) in the United States considers all products containing aristolochic acid to be unsafe.
Amiloride, Hydrochlorothiazide Overview
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The combination of amiloride and hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure and heart failure in patients who have low amounts of potassium in their bodies or for whom low potassium levels in the body could be dangerous. Amiloride and hydrochlorothiazide are in a class of medications called diuretics ('water pills'). They work by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
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High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Aristolochia - More Interactions
Aristolochia interacts with 350 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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