Drug & supplement interaction

Oscillococcinum + Amiloride, Hydrochlorothiazide

Amiloride, Hydrochlorothiazide brand names: Moduretic, Amilzide, Moduret 25, Amil-Co.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Oscillococcinum and Amiloride, Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Amiloride, Hydrochlorothiazide states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Oscillococcinum and Amiloride, Hydrochlorothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amiloride, Hydrochlorothiazide and Oscillococcinum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Oscillococcinum at all — not against Amiloride, Hydrochlorothiazide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Oscillococcinum safety at a glance

Oscillococcinum overall Use caution Generally well tolerated, but evidence of benefit is lacking and it should not replace proven flu care.
Pregnancy Use caution Safety has not been well studied in pregnancy, so check with your doctor first.
Breastfeeding Use caution Little data exists during breastfeeding, so use only with medical guidance.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amiloride, Hydrochlorothiazide and Oscillococcinum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Oscillococcinum and Amiloride, Hydrochlorothiazide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache Additional detail

    Oscillococcinum

    “Orally, oscillococcinum has been associated with one report of headache in one clinical study.”

    Oscillococcinum · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 19063. Papp R, Schuback G, Beck E, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double-blind evaluation. British Homoeopathic Journal 1998;87:69-76.

    Amiloride, Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Amiloride, Hydrochlorothiazide. Read the label on DailyMed ›

Reported for Oscillococcinum but not commonly for Amiloride, Hydrochlorothiazide: a severe allergic reaction.

Effects for Amiloride, Hydrochlorothiazide come from the ADVERSE REACTIONS section of its FDA label; effects for Oscillococcinum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Amiloride, Hydrochlorothiazide Products Have a Food Rule — Oscillococcinum Should Not Break It

At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Oscillococcinum on an empty stomach out of habit, keep them separate — and take Amiloride, Hydrochlorothiazide with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Amiloride, Hydrochlorothiazide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Amiloride hydrochloride and hydrochlorothiazide tablets should be administered with food.

From the Dosage and Administration section of the FDA label we read for Amiloride, Hydrochlorothiazide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Amiloride, Hydrochlorothiazide

This page covers Oscillococcinum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride, Hydrochlorothiazide page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 27 minor.

From our pharmacist’s overview on the Amiloride, Hydrochlorothiazide page

“The typical Moduretic (amiloride with hydrochlorothiazide) patient is managing blood pressure long term, and the supplements that crowd reaches for (herbal blood pressure aids, potassium, calcium) are exactly what fills this list. It deserves a careful read, not a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Amiloride, Hydrochlorothiazide interaction page

How much people look this up

Where Oscillococcinum and Amiloride, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oscillococcinum
Steady interest

#1,266 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amiloride, Hydrochlorothiazide
Top 25%

#304 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Oscillococcinum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Oscillococcinum and Amiloride, Hydrochlorothiazide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Oscillococcinum

What is Oscillococcinum?

  • Flu-like symptoms
  • Common cold symptoms
  • Body aches and chills
  • Fatigue during illness
  • Fever associated with the flu

Oscillococcinum is a homeopathic product made from extremely diluted duck liver and heart, marketed to ease flu-like symptoms. High-quality research has not shown it works better than a placebo, but it is generally well tolerated. If you choose to try it, see it as a low-risk option rather than a proven treatment, and don't use it to replace a flu vaccine or needed medical care.

Anas barbariae hepatis et cordis extractum · Highly diluted extract of duck liver and heart (Muscovy duck) · Oral pellets/granules that dissolve under the tongue

An interaction check asks whether these two react with each other — it does not ask whether Oscillococcinum is a good idea for someone in your situation. Here is what our Oscillococcinum record says about it on its own.

Oscillococcinum: dosing

There is no scientifically established effective dose for Oscillococcinum, since it has not been shown to work. If you choose to use it, follow the directions on the product label exactly.The pellets are typically dissolved under the tongue rather than swallowed with water, and packages often suggest starting at the first sign of symptoms.

From our Oscillococcinum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Oscillococcinum monograph & all interactions
Medication

About Amiloride and Hydrochlorothiazide

What Is Amiloride and Hydrochlorothiazide Used For?

Brand names: Moduretic, Amilzide, Moduret 25, Amil-Co

Amiloride hydrochloride and hydrochlorothiazide tablets are used for patients with high blood pressure (hypertension) or congestive heart failure who tend to develop low potassium (hypokalemia) when taking a thiazide or other diuretic alone — or for whom keeping potassium levels in a normal range is especially important, such as people taking digoxin or those with significant heart rhythm problems.

The tablets may be used on their own or alongside other blood pressure medicines, such as methyldopa or beta blockers. This combination product is not intended as the first-choice treatment for swelling (edema) or high blood pressure unless low potassium is a specific concern.

See full Amiloride and Hydrochlorothiazide drug information
Keep checking

Other Drugs & Oscillococcinum

Browse every other medication we’ve checked against Oscillococcinum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Oscillococcinum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Oscillococcinum list.

See the full Oscillococcinum interactions page
See every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity
Evidence & sources

Oscillococcinum References

The 2 references that drive our Oscillococcinum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Papp R, Schuback G, Beck E, et al. Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double-blind evaluation. British Homoeopathic Journal 1998;87:69-76.
  2. Azmi Y, Rao M, Verma I, Agrawal A. Oscillococcinum leading to angioedema, a rare adverse event. BMJ Case Rep. 2015 Jun 2;2015. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Oscillococcinum and Amiloride, Hydrochlorothiazide Together: Common Questions

Is it safe to take Oscillococcinum with Amiloride, Hydrochlorothiazide?
We do not list a known interaction between Oscillococcinum and Amiloride, Hydrochlorothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Oscillococcinum and Amiloride, Hydrochlorothiazide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Oscillococcinum and Amiloride, Hydrochlorothiazide at the same time of day?
At least one FDA label for a product containing Amiloride, Hydrochlorothiazide says to take it with food. If you take Oscillococcinum on an empty stomach out of habit, keep them separate and take Amiloride, Hydrochlorothiazide with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Amiloride, Hydrochlorothiazide products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Amiloride, Hydrochlorothiazide interact with any supplements?
Yes. Amiloride, Hydrochlorothiazide has documented interactions with 236 supplements in our database — Oscillococcinum is not one of them. The Amiloride, Hydrochlorothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Oscillococcinum monograph Uses, safety profile, and every drug interaction in one place Amiloride and Hydrochlorothiazide drug information The full plain-English guide to this medication Amiloride, Hydrochlorothiazide supplement interactions Every supplement checked against Amiloride, Hydrochlorothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amiloride, Hydrochlorothiazide and Oscillococcinum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.