Drug & supplement interaction

Prenatal Vitamins + Ospemifene

Ospemifene brand name: Osphena.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Prenatal Vitamins and Ospemifene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ospemifene states a food rule worth keeping to.

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Interaction report

Prenatal Vitamins and Ospemifene

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ospemifene and Prenatal Vitamins in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Prenatal Vitamins at all — not against Ospemifene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Prenatal Vitamins safety at a glance

Prenatal Vitamins overall Generally safe Generally safe when taken as directed, though they can cause mild stomach upset or constipation.
Pregnancy Likely Safe When used orally. Prenatal vitamins contain many different minerals, vitamins, and sometimes other dietary supplement ingredients. Each individual ingredient ha... Read the full pregnancy detail
Breastfeeding Possibly Safe When used orally. Prenatal vitamins usually do not contain ingredients in amounts that exceed the tolerable upper intake level (UL). The UL is the highest level... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ospemifene and Prenatal Vitamins? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ospemifene’s Own FDA Label Lists

This is not an interaction — none of it involves Prenatal Vitamins. These are the most notable effects listed in the ADVERSE REACTIONS section of Ospemifene’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on
  • Blood clots Worth acting on
  • Bleeding or bruising Worth acting on mentioned in 5.8% of FDA reports for Ospemifene
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Flushing mentioned in 14.3% of FDA reports for Ospemifene
  • Muscle pain mentioned in 7.5% of FDA reports for Ospemifene
  • Sweating
  • Itching

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ospemifene. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,601 voluntary FDA FAERS reports for Ospemifene that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Prenatal Vitamins’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Prenatal Vitamins side to compare — that is a limit of the record, not a statement that Prenatal Vitamins has no side effects.

Special populations

Prenatal Vitamins in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally. Prenatal vitamins contain many different minerals, vitamins, and sometimes other dietary supplement ingredients. Each individual ingredient has a unique safety profile. Clinical studies evaluating prenatal vitamins show that prenatal vitamins are safe when used appropriately during pregnancy.

Lactation Possibly Safe

When used orally. Prenatal vitamins usually do not contain ingredients in amounts that exceed the tolerable upper intake level (UL). The UL is the highest level of nutrient intake that is unlikely to have a risk of adverse effects for most people, as determined by the Food and Nutrition Board and the National Academies of Science. Therefore, prenatal vitamins have apparent safety during lactation. However, high quality research assessing the safety of prenatal vitamins during lactation is lacking.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Ospemifene Products Have a Food Rule — Prenatal Vitamins Should Not Break It

At least one FDA label for a product containing Ospemifene says to take it with food. If you take Prenatal Vitamins on an empty stomach out of habit, keep them separate — and take Ospemifene with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ospemifene products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

One tablet taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Ospemifene — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Prenatal Vitamins or Ospemifene

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Prenatal Vitamins or Ospemifene, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ospemifene

This page covers Prenatal Vitamins only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ospemifene page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Tiratricol (major) and Acacia Rigidula (moderate).

By severity: 4 major · 112 moderate · 39 minor.

From our pharmacist’s overview on the Ospemifene page

“Women prescribed ospemifene (Osphena) for painful intercourse after menopause are often the same women reaching for St. John's wort for mood or grapefruit juice at breakfast, and both sit among the four major-rated interactions on this page, so the list deserves genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Ospemifene interaction page

How much people look this up

Where Prenatal Vitamins and Ospemifene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Prenatal Vitamins
Steady interest

#1,086 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ospemifene
Steady interest

#2,474 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Prenatal Vitamins reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Prenatal Vitamins and Ospemifene records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Prenatal Vitamins

What is Prenatal Vitamins?

  • Nutritional support before and during pregnancy
  • Preventing neural tube defects (folic acid)
  • Supporting healthy fetal development
  • Preventing iron-deficiency anemia in pregnancy
  • Support during breastfeeding

Prenatal vitamins are multivitamin-mineral supplements designed to fill nutritional gaps before and during pregnancy and while breastfeeding, with folic acid and iron being especially important. They are widely recommended by doctors, but they do not replace a healthy diet, and you should choose a product and dose with guidance from your pharmacist or doctor.

Tablets, capsules, soft gels, chewables, gummies, liquids

An interaction check asks whether these two react with each other — it does not ask whether Prenatal Vitamins is a good idea for someone in your situation. Here is what our Prenatal Vitamins record says about it on its own.

Prenatal Vitamins: dosing

There is no single "correct" prenatal vitamin, since products differ in their ingredients and amounts. Most are taken once daily, but some require more than one tablet or a separate DHA softgel.

From our Prenatal Vitamins monograph — the full record covers uses, side effects and every documented interaction.

Read the full Prenatal Vitamins monograph & all interactions
Medication

About Ospemifene

What Is Ospemifene Used For?

Brand name: Osphena

Osphena (ospemifene) is used to treat two specific symptoms of vulvar and vaginal atrophy — the thinning and drying of vaginal tissues that can happen after menopause. The first is moderate to severe dyspareunia (painful intercourse), and the second is moderate to severe vaginal dryness.

Both of these uses are for postmenopausal women only. Osphena is not used in children or in women who are pregnant or may become pregnant.

Most-Reported Side Effects for Ospemifene

From FAERS, the FDA’s public side-effect reporting system (2,601 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hot flush 372 reports
Headache 209 reports
Muscle spasms 194 reports
Vaginal haemorrhage 150 reports
Vaginal discharge 134 reports
See full Ospemifene drug information
Keep checking

Other Drugs & Prenatal Vitamins

Browse every other medication we’ve checked against Prenatal Vitamins — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Prenatal Vitamins against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Prenatal Vitamins list.

See the full Prenatal Vitamins interactions page
See every supplement checked against Ospemifene, ranked by severity
Evidence & sources

Prenatal Vitamins References

The 18 references that drive our Prenatal Vitamins monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.
  2. Bentley S, Hermes A, Phillips D, Daoud YA, Hanna S. Comparative effectiveness of a prenatal medical food to prenatal vitamins on hemoglobin levels and adverse outcomes: a retrospective analysis. Clin Ther. 2011;33(2):204-10. PubMed
  3. Braun JM, Froehlich T, Kalkbrenner A. Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations? J Autism Dev Disord. 2014;44(10):2602-7. PubMed
  4. Dougan MM, Willett WC, Michels KB. Prenatal vitamin intake during pregnancy and offspring obesity. Int J Obes. 2015;39(1):69-74. PubMed
  5. Sauder KA, Starling AP, Shapiro AL, et al. Exploring the association between maternal prenatal multivitamin use and early infant growth: The Healthy Start Study. Pediatr Obes. 2016;11(5):434-41. PubMed
  6. Riley LE, Stark AR, Kilpatrick SJ, et al. Guidelines for Perinatal Care. 7th ed. Washington, DC: The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists; 2012.
  7. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992;327(26):1832-5. PubMed
  8. Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ. 1993;306(6893):1645-8. PubMed
  9. Scholl TO, Hediger ML, Bendich A, et al. Use of multivitamin/mineral prenatal supplements: influence on the outcome of pregnancy. Am J Epidemiol. 1997;146(2):134-41. PubMed
  10. Goh YI, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol Ther. 2007 May;81(5):685-91. PubMed
  11. Goh YI, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can. 2006 Aug;28(8):680-9. Review. PubMed
  12. Balogun OO, da Silva Lopes K, Ota E, et al. Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev. 2016 May 6;(5):CD004073. PubMed
  13. Dean SV, Lassi ZS, Imam AM, Bhutta ZA. Preconception care: nutritional risks and interventions. Reprod Health. 2014;11 Suppl 3:S3. PubMed
  14. Virk J, Liew Z, Olsen J, Nohr EA, Catov JM, Ritz B. Pre-conceptual and prenatal supplementary folic acid and multivitamin intake, behavioral problems, and hyperkinetic disorders: A study based on the Danish National Birth Cohort (DNBC). Nutr Neurosci. 201 PubMed
  15. Wolf HT, Hegaard HK, Huusom LD, Pinborg AB. Multivitamin use and adverse birth outcomes in high-income countries: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;217(4):404.e1-404.e30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Prenatal Vitamins and Ospemifene Together: Common Questions

Is it safe to take Prenatal Vitamins with Ospemifene?
We do not list a known interaction between Prenatal Vitamins and Ospemifene. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Prenatal Vitamins and Ospemifene at the same time of day?
At least one FDA label for a product containing Ospemifene says to take it with food. If you take Prenatal Vitamins on an empty stomach out of habit, keep them separate and take Ospemifene with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ospemifene products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Ospemifene interact with any supplements?
Yes. Ospemifene has documented interactions with 155 supplements in our database — Prenatal Vitamins is not one of them. The Ospemifene interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Prenatal Vitamins monograph Uses, safety profile, and every drug interaction in one place Ospemifene drug information The full plain-English guide to this medication Ospemifene supplement interactions Every supplement checked against Ospemifene, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ospemifene and Prenatal Vitamins?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.