Drug & supplement interaction

Propionyl-l-carnitine + Infliximab

Infliximab brand name: Remicade.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Propionyl-l-carnitine and Infliximab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Propionyl-l-carnitine and Infliximab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Infliximab and Propionyl-l-carnitine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Propionyl-l-carnitine safety at a glance

Propionyl-l-carnit... overall Use caution Generally well tolerated for short-term use, but talk to a healthcare provider first.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety data is available, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Infliximab and Propionyl-l-carnitine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Propionyl-l-carnitine Does Interact With Other Medications

Propionyl-l-carnitine has 19 moderate known drug interactions in our database — Infliximab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 19 No known interaction 2,811 (incl. Infliximab)
Taking anything else?

Check Another of Your Medications Against Propionyl-l-carnitine

Covers the 2,830 medications we’ve checked against Propionyl-l-carnitine. Pick one to open its full report.

What to actually watch for

What Propionyl-l-carnitine Itself Has Been Linked To

This is not an interaction — nothing below involves Infliximab. It is the side-effect record for Propionyl-l-carnitine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Propionyl-l-carnitine, this list is the first place to look.

  • Back pain Additional detail

    “Orally, back pain was reported more frequently with propionyl-L-carnitine when compared with placebo in one clinical trial.”

    Propionyl-l-carnitine · Natural Medicines adverse-effect record, reported in back pain.

    1 source cited
    1. 94443. Hiatt WR, Creager MA, Amato A, Brass EP. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. J Cardiopulm Rehabil Prev 2011;31:125-32. PubMed
  • Diarrhea / Vomiting / Nausea Additional detail

    “Orally, nausea, vomiting, diarrhea, and gastric pain have been reported with propionyl-L-carnitine use.”

    Propionyl-l-carnitine · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 1579. Cherchi A, Lai C, Onnis E, et al. Propionyl carnitine in stable effort angina. Cardiovasc Drugs Ther 1990;4:481-6. PubMed
    2. 1580. Bartels GL, Remme WJ, den Hartog FR, et al. Additional anti-ischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy. Cardiovasc Drugs Ther 1995;9:749-53.
    3. 1582. Caponnetto S, Canale C, Masperone MA, et al. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. Eur Heart J 1994;15:1267-73. PubMed
    4. 12682. Gentile V, Vicini P, Prigiotti G, et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. Curr Med Res Opin 2004;20:1377-84. PubMed
    5. 94439. Brass EP, Koster D, Hiatt WR, Amato A. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. Vasc Med 2013;18:3-12.
    6. 94443. Hiatt WR, Creager MA, Amato A, Brass EP. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. J Cardiopulm Rehabil Prev 2011;31:125-32. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Propionyl-l-carnitine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Infliximab’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Infliximab column appears here.

Overlapping uses

What Infliximab Is Prescribed For, and What Propionyl-l-carnitine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Infliximab is a prescription medicine with approved uses on its FDA label. Propionyl-l-carnitine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Infliximab is prescribed for: Infliximab injection is used to treat several serious inflammatory conditions. It treats moderately to severely active Crohn's disease (including fistulizing disease) and ulcerative colitis in adults, and in children ages 6 and older. It also treats moderately to severely active rheumatoid arthritis (in combination with methotrexate), ankylosing spondylitis (a type of spinal arthritis), psoriatic arthritis, and chronic severe plaque psoriasis in adults. Infliximab is intended for patients whose disease has not responded well enough to conventional therapies.

Read the rest of what Infliximab is prescribed for

It is available under the brand names INFLECTRA, Remicade, and Renflexis, all given by intravenous (IV) infusion.

Propionyl-l-carnitine has been studied for:

  • Ulcerative colitis Natural Medicines rates the evidence for Propionyl-l-carnitine: Possibly Effective Read what the research shows

    Propionyl-l-carnitine for ulcerative colitis

    Oral propionyl-L-carnitine may improve clinical response and remission rates in patients with mild to moderate ulcerative colitis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Infliximab on your own; if you are taking Propionyl-l-carnitine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Propionyl-l-carnitine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 57 real supplement products containing Propionyl-l-carnitine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Propionyl-l-carnitine. Even though Propionyl-l-carnitine itself has no known interaction with Infliximab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Propionyl-l-carnitine and Infliximab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Propionyl-l-carnitine
Top half

#483 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Infliximab
Top half

#1,290 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Propionyl-l-carnitine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Propionyl-l-carnitine and Infliximab records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Propionyl-l-carnitine

What is Propionyl-l-carnitine?

  • Peripheral artery disease and leg pain
  • Heart and circulation support
  • Energy and exercise performance
  • Erectile dysfunction
  • Diabetic nerve pain

Propionyl-l-carnitine is a form of the amino acid derivative carnitine that the body uses to help turn fat into energy, and it is studied mostly for circulation problems like peripheral artery disease. Some evidence suggests it may help walking distance in people with poor leg circulation, but results are mixed and it is not a substitute for standard medical care. Talk to a pharmacist or doctor before using it, especially if you have a medical condition or take other medicines.

Capsules, tablets, oral powder

An interaction check asks whether these two react with each other — it does not ask whether Propionyl-l-carnitine is a good idea for someone in your situation. Here is what our Propionyl-l-carnitine record says about it on its own.

Propionyl-l-carnitine: dosing

There is no single official dose of PLC for supplement use, and the right amount can depend on the condition being studied and the specific product. They can help you decide whether PLC is appropriate for you and what amount makes sense.Do not assume more is better. Higher doses raise the chance of side effects without guaranteeing more benefit.

From our Propionyl-l-carnitine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Propionyl-l-carnitine monograph & all interactions
Medication

About Infliximab Injection

What Is Infliximab Injection Used For?

Brand name: Remicade

Infliximab injection is used to treat several serious inflammatory conditions. It treats moderately to severely active Crohn's disease (including fistulizing disease) and ulcerative colitis in adults, and in children ages 6 and older. It also treats moderately to severely active rheumatoid arthritis (in combination with methotrexate), ankylosing spondylitis (a type of spinal arthritis), psoriatic arthritis, and chronic severe plaque psoriasis in adults.

Infliximab is intended for patients whose disease has not responded well enough to conventional therapies. It is available under the brand names INFLECTRA, Remicade, and Renflexis, all given by intravenous (IV) infusion.

Most-Reported Side Effects for Infliximab

From FAERS, the FDA’s public side-effect reporting system (243,742 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 21,885 reports
Fatigue 19,677 reports
Infusion related reaction 19,598 reports
Rheumatoid arthritis 18,789 reports
Nausea 14,435 reports
See full Infliximab Injection drug information
Keep checking

Other Drugs & Propionyl-l-carnitine

Browse every other medication we’ve checked against Propionyl-l-carnitine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
19Moderate
0Minor
2,810No known interaction
19 Moderate 2,810 No interaction
Moderate

19 interactions

No interaction 2,810 drugs checked — show the list

We also checked Propionyl-l-carnitine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,810 medications checked with no known interaction — see the full Propionyl-l-carnitine list.

See the full Propionyl-l-carnitine interactions page
See every supplement checked against Infliximab, ranked by severity
Evidence & sources

Propionyl-l-carnitine References

The 12 references that drive our Propionyl-l-carnitine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cherchi A, Lai C, Onnis E, et al. Propionyl carnitine in stable effort angina. Cardiovasc Drugs Ther 1990;4:481-6. PubMed
  2. Bartels GL, Remme WJ, den Hartog FR, et al. Additional anti-ischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy. Cardiovasc Drugs Ther 1995;9:749-53.
  3. Caponnetto S, Canale C, Masperone MA, et al. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. Eur Heart J 1994;15:1267-73. PubMed
  4. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  5. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  6. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  7. Gentile V, Vicini P, Prigiotti G, et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. Curr Med Res Opin 2004;20:1377-84. PubMed
  8. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  9. Brass EP, Koster D, Hiatt WR, Amato A. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. Vasc Med 2013;18:3-12.
  10. Hiatt WR, Creager MA, Amato A, Brass EP. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. J Cardiopulm Rehabil Prev 2011;31:125-32. PubMed
  11. Jacobs PL, Goldstein ER, Blackburn W, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr 2009;6:9. PubMed
  12. Jacobs PL, Goldstein ER. Long-term glycine propionyl-l-carnitine supplementation and paradoxical effects on repeated anaerobic sprint performance. J Int Soc Sports Nutr 2010;7:35.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Propionyl-l-carnitine and Infliximab Together: Common Questions

Is it safe to take Propionyl-l-carnitine with Infliximab?
We do not list a known interaction between Propionyl-l-carnitine and Infliximab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Propionyl-l-carnitine and Infliximab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Propionyl-l-carnitine in each. That is a conversation for your prescriber, especially if Infliximab is being adjusted to a target.
Does Propionyl-l-carnitine interact with any other medications?
Yes. Propionyl-l-carnitine has 19 documented drug interactions in our database — Infliximab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Propionyl-l-carnitine monograph Uses, safety profile, and every drug interaction in one place Infliximab Injection drug information The full plain-English guide to this medication Infliximab supplement interactions Every supplement checked against Infliximab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Infliximab and Propionyl-l-carnitine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.