Drug & supplement interaction

Reflexology + Diazepam

Diazepam brand names: Valium, Valium injection, Diastat AcuDial, Valtoco.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Reflexology and Diazepam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Reflexology and Diazepam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diazepam and Reflexology in our sources. This does not guarantee that the combination is completely free of risk — research on Reflexology alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Reflexology at all — not against Diazepam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Reflexology is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Reflexology safety at a glance

Reflexology overall Use caution Generally low-risk for most people, but it is not a substitute for medical care.
Pregnancy Possibly Safe When used appropriately. Reflexology has been used during pregnancy with apparent safety. Read the full pregnancy detail
Breastfeeding Possibly Safe When used appropriately. Reflexology has been used with apparent safety in lactating women. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diazepam and Reflexology? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Reflexology and Diazepam May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so having Reflexology while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tiredness Additional detail

    Reflexology

    “Some practitioners of reflexology indicate that some patients, following a treatment session, can experience symptoms of malaise, fatigue, nausea, or flu-like symptoms. Reflexology is believed to stimulate the body to eliminate metabolic "toxins." These potential side effects are believed to be due to this process; however, there is no reliable scientific evidence to support this belief.”

    Reflexology · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 15827. Blunt E. Foot reflexology. Holist Nurs Pract 2006;20:257-9.

    Diazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Diazepam. Read the label on DailyMed ›

Reported for Reflexology but not commonly for Diazepam: nausea.

Effects for Diazepam come from the ADVERSE REACTIONS section of its FDA label; effects for Reflexology come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Reflexology in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used appropriately. Reflexology has been used during pregnancy with apparent safety.

Lactation Possibly Safe

When used appropriately. Reflexology has been used with apparent safety in lactating women.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Diazepam Is Prescribed For, and What Reflexology Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Diazepam is a prescription medicine with approved uses on its FDA label. Reflexology is a treatment: what follows is what researchers have looked at it for, and how strong that evidence is.

Diazepam is prescribed for: Diazepam treats several different problems, depending on the product. Oral diazepam (tablets such as Valium, and oral solution) is used for anxiety disorders, short-term relief of anxiety symptoms, and symptom relief in acute alcohol withdrawal. It is also used alongside other treatments for muscle spasm and, adjunctively, for convulsive disorders (seizure disorders). Diazepam injection is used for the same anxiety and alcohol withdrawal uses.

Read the rest of what Diazepam is prescribed for

It is also used before endoscopic procedures, before surgery, and before cardioversion (when given intravenously). It helps with muscle spasm and tetanus, and with status epilepticus (a prolonged, dangerous seizure) as an add-on. Diazepam rectal gel and Valtoco nasal spray are used only for seizure clusters (acute repetitive seizures) in people with epilepsy ages 2 and older.

Reflexology has been studied for:

  • Epilepsy studied, not established Reflexology has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Reflexology for epilepsy

    Preliminary clinical research shows that adding reflexology to standard treatment with antiepileptic drugs might reduce seizure frequency compared to using antiepileptic drugs alone in patients with intractable epilepsy. This study was limited by unclear reporting of outcomes.

    1 source cited
    1. 98108. Dalal K, Devarajan E, Pandey RM, Subbiah V, Tripathi M. Role of reflexology and antiepileptic drugs in managing intractable epilepsy--a randomized controlled trial. Forsch Komplementmed. 2013;20(2):104-11. PubMed
  • Anxiety studied, not established Reflexology has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Reflexology for anxiety

    Most clinical research shows that foot reflexology is beneficial for reducing anxiety due to various causes, although it may not be beneficial in all patient populations. A meta-analysis of preliminary clinical research shows that foot reflexology has a large beneficial effect on anxiety related to various illnesses or procedures when compared to control.

    6 sources cited
    1. 107680. Wang WL, Hung HY, Chen YR, et al. Effect of foot reflexology intervention on depression, anxiety, and sleep quality in adults: A meta-analysis and metaregression of randomized controlled trials. Evid Based Complement Alternat Med 2020;2020:2654353. PubMed
    2. 101629. Bahrami T, Rejeh N, Heravi-Karimooi M, Tadrisi SD, Vaismoradi M. The Effect of Foot Reflexology on Hospital Anxiety and Depression in Female Older Adults: a Randomized Controlled Trial. Int J Ther Massage Bodywork. 2019;12(3):16-21. DOI
    3. 107679. Alinia-Najjar R, Bagheri-Nesami M, Shorofi SA, Mousavinasab SN, Saatchi K. The effect of foot reflexology massage on burn-specific pain anxiety and sleep quality and quantity of patients hospitalized in the burn intensive care unit (ICU). Burns 2020;46(8) PubMed
    4. 107684. Davodabady F, Naseri-Salahshour V, Sajadi M, Mohtarami A, Rafiei F. Randomized controlled trial of the foot reflexology on pain and anxiety severity during dressing change in burn patients. Burns 2021;47(1):215-221. PubMed
    5. 107687. Sayari S, Nobahar M, Ghorbani R. Effect of foot reflexology on chest pain and anxiety in patients with acute myocardial infarction: A double blind randomized clinical trial. Complement Ther Clin Pract 2021;42:101296. PubMed
    6. 107686. Murat-Ringot A, Souquet PJ, Subtil F, Boutitie F, Preau M, Piriou V. The effect of foot reflexology on chemotherapy-induced nausea and vomiting in patients with digestive or lung cancer: Randomized controlled trial. JMIR Cancer 2021;7(4):e25648. PubMed
  • Cerebral palsy studied, not established Reflexology has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Reflexology for cerebral palsy

    Preliminary clinical research in children with cerebral palsy shows that receiving 20 minutes of reflexology twice weekly for 12 weeks reduces leg spasticity and attenuates the worsening of motor function when compared with placebo-reflexology and no additional treatment.

    1 source cited
    1. 98122. Özkan F, Zincir H. The effect of reflexology upon spasticity and function among children with cerebral palsy who received physiotherapy: Three group randomised trial. Appl Nurs Res. 2017;36:128-134. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Diazepam on your own; if you are taking Reflexology for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Reflexology or Diazepam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Reflexology or Diazepam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diazepam

This page covers Reflexology only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diazepam page lists 244 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 191 moderate · 44 minor.

Open the Diazepam interaction page

How much people look this up

Where Reflexology and Diazepam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Reflexology
Steady interest

#1,136 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diazepam
Top 10%

#244 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Reflexology reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Reflexology and Diazepam records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Reflexology

What is Reflexology?

  • Stress and relaxation
  • Anxiety
  • Pain relief
  • Sleep problems
  • Easing cancer-treatment symptoms
  • General well-being

Reflexology is a hands-on therapy where a practitioner applies pressure to specific points on the feet, hands, or ears, based on the idea that these points map to other parts of the body. Most people find it relaxing, and it appears generally safe, but solid evidence that it treats specific medical conditions is limited. It is best viewed as a complementary, relaxation-focused practice rather than a cure.

Not applicable (a hands-on therapy, not a plant or supplement) · In-person sessions with a trained reflexologist; foot, hand, or ear reflexology

An interaction check asks whether these two react with each other — it does not ask whether Reflexology is a good idea for someone in your situation. Here is what our Reflexology record says about it on its own.

Reflexology: dosing

There is no standardized "dose" for reflexology because it is a hands-on therapy, not something you take. Sessions commonly last around 30 to 60 minutes, and how often people go varies widely based on personal preference and budget.If you want to try it, look for a trained, reputable practitioner, share your health history, and start with an occasional session to see how you respond.

From our Reflexology monograph — the full record covers uses, side effects and every documented interaction.

Read the full Reflexology monograph & all interactions
Medication

About Diazepam

What Is Diazepam Used For?

Brand names: Valium, Valium injection, Diastat AcuDial, Valtoco

Diazepam treats several different problems, depending on the product. Oral diazepam (tablets such as Valium, and oral solution) is used for anxiety disorders, short-term relief of anxiety symptoms, and symptom relief in acute alcohol withdrawal. It is also used alongside other treatments for muscle spasm and, adjunctively, for convulsive disorders (seizure disorders).

Diazepam injection is used for the same anxiety and alcohol withdrawal uses. It is also used before endoscopic procedures, before surgery, and before cardioversion (when given intravenously). It helps with muscle spasm and tetanus, and with status epilepticus (a prolonged, dangerous seizure) as an add-on. Diazepam rectal gel and Valtoco nasal spray are used only for seizure clusters (acute repetitive seizures) in people with epilepsy ages 2 and older.

See full Diazepam drug information
Keep checking

Other Drugs & Reflexology

Browse every other medication we’ve checked against Reflexology — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Reflexology against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Reflexology list.

See the full Reflexology interactions page
See every supplement checked against Diazepam, ranked by severity
Evidence & sources

Reflexology References

The 75 references that drive our Reflexology monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blunt E. Foot reflexology. Holist Nurs Pract 2006;20:257-9.
  2. Stephenson NL, Dalton JA. Using reflexology for pain management. A review. J Holist Nurs 2003;21:179-91. PubMed
  3. Stephenson N, Dalton JA, Carlson J. The effect of foot reflexology on pain in patients with metastatic cancer. Appl Nurs Res 2003;16:284-6. PubMed
  4. Tipping L, Mackereth PA. A concept analysis: the effect of reflexology on homeostasis to establish and maintain lactation. Complement Ther Nurs Midwifery 2000;6:189-98. PubMed
  5. Mak HL, Cheon WC, Wong T, et al. Randomized controlled trial of foot reflexology for patients with symptomatic idiopathic detrusor overactivity. Int Urogynecol J Pelvic Floor Dysfunct 2007;18:653-8. PubMed
  6. Wilkinson IS, Prigmore S, Rayner CF. A randomised-controlled trail examining the effects of reflexology of patients with chronic obstructive pulmonary disease (COPD). Complement Ther Clin Pract 2006;12:141-7. PubMed
  7. McNeill JA, Alderdice FA, McMurray F. A retrospective cohort study exploring the relationship between antenatal reflexology and intranatal outcomes. Complement Ther Clin Pract 2006;12:119-25. PubMed
  8. Tiran D, Chummun H. The physiological basis of reflexology and its use as a potential diagnostic tool. Complement Ther Clin Pract 2005;11:58-64. PubMed
  9. Siev-Ner I, Gamus D, Lerner-Geva L, Achiron A. Reflexology treatment relieves symptoms of multiple sclerosis: a randomized controlled study. Mult Scler 2003;9:356-61.
  10. Mollart L. Single-blind trial addressing the differential effects of two reflexology techniques versus rest, on ankle and foot oedema in late pregnancy. Complement Ther Nurs Midwifery 2003;9:203-8. PubMed
  11. Bishop E, McKinnon E, Weir E, Brown DW. Reflexology in the management of encopresis and chronic constipation. Paediatr Nurs 2003;15:20-1. DOI
  12. Ross CS, Hamilton J, Macrae G, et al. A pilot study to evaluate the effect of reflexology on mood and symptom rating of advanced cancer patients. Palliat Med 2002;16:544-5. PubMed
  13. Williamson J, White A, Hart A, Ernst E. Randomised controlled trial of reflexology for menopausal symptoms. BJOG 2002;109:1050-5. PubMed
  14. Tovey P. A single-blind trial of reflexology for irritable bowel syndrome. Br J Gen Pract 2002;52:19-23.
  15. Oleson T, Flocco W. Randomized controlled study of premenstrual symptoms treated with ear, hand, and foot reflexology. Obstet Gynecol 1993;82(6):906-11.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Reflexology While Taking Diazepam: Common Questions

Is it safe to have Reflexology while taking Diazepam?
We do not list a known interaction between Reflexology and Diazepam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Reflexology and Diazepam have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Reflexology and Diazepam used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Reflexology in each. That is a conversation for your prescriber, especially if Diazepam is being adjusted to a target.
Does Diazepam interact with any supplements?
Yes. Diazepam has documented interactions with 244 supplements in our database — Reflexology is not one of them. The Diazepam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Reflexology monograph Uses, safety profile, and every drug interaction in one place Diazepam drug information The full plain-English guide to this medication Diazepam supplement interactions Every supplement checked against Diazepam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 75 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diazepam and Reflexology?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.