Drug & supplement interaction

Ribose + Guaifenesin, Hydrocodone, Pseudoephedrine

Guaifenesin, Hydrocodone, Pseudoephedrine brand names: Tussi-Organidin DM NR, Entuss-D.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Guaifenesin, Hydrocodone, Pseudoephedrine and Ribose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ribose safety at a glance

Ribose overall Use caution Often well tolerated short-term, but it can lower blood sugar and long-term safety is not well studied.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Guaifenesin, Hydrocodone, Pseudoephedrine and Ribose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Guaifenesin, Hydrocodone, Pseudoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Guaifenesin, Hydrocodone, Pseudoephedrine is filed under 9 classifications — including narcotic drugs, alpha-adrenergic agonists, stimulant drugs. Ribose has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and insulin (moderate) — and none of Guaifenesin, Hydrocodone, Pseudoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ribose Does Interact With Other Medications

Ribose has 86 moderate known drug interactions in our database — Guaifenesin, Hydrocodone, Pseudoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Guaifenesin, Hydrocodone, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Ribose

Covers the 2,830 medications we’ve checked against Ribose. Pick one to open its full report.

What to actually watch for

What Ribose Itself Has Been Linked To

This is not an interaction — nothing below involves Guaifenesin, Hydrocodone, Pseudoephedrine. It is the side-effect record for Ribose on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ribose, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on Additional detail

    “Orally, ribose can decrease blood glucose levels. In one pharmacokinetic study, fasting plasma glucose declined after single ribose doses of 2.5-10 grams. At all doses, serum glucose returned to near normal 2 hours post-administration but remained slightly below pre-dose levels for up to 5 hours. One case of symptomatic hypoglycemia 70 minutes post-dose was reported in a 53 kg female who took ribose 10 grams.”

    Ribose · Natural Medicines adverse-effect record, reported in hypoglycemia.

    6 sources cited
    1. 5667. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
    2. 92891. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed
    3. 5650. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
    4. 5662. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
    5. 5663. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
    6. 5676. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  • Increased appetite / Anxiety or restlessness / Dizziness Additional detail

    “Orally, ribose can cause headache. It has also been reported to cause a hyperanxious feeling, lightheadedness, increased appetite, and mild anxiety. In one study, lowering the dose of ribose resolved the feeling of anxiety.”

    Ribose · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 5664. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
    2. 92891. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed
    3. 15218. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  • Stomach upset / Diarrhea / Nausea Additional detail

    “Orally, ribose can cause diarrhea, gastrointestinal discomfort, and nausea. In one study, lowering the dose of ribose resolved the nausea.”

    Ribose · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 5664. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
    2. 5676. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
    3. 15218. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
    4. 92891. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed
  • Headache Additional detail

    Recorded for Ribose in the same Natural Medicines adverse-effect record shown under Low blood sugar above.

Everything above comes from the Natural Medicines adverse-effect record for Ribose — expand a row for the licensed statement it rests on. We haven’t matched Guaifenesin, Hydrocodone, Pseudoephedrine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Guaifenesin, Hydrocodone, Pseudoephedrine.

Everything else you take

See Every Supplement That Interacts With Guaifenesin, Hydrocodone, Pseudoephedrine

This page covers Ribose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guaifenesin, Hydrocodone, Pseudoephedrine page lists 241 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Ephedra (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 13 major · 190 moderate · 38 minor.

From our pharmacist’s overview on the Guaifenesin, Hydrocodone, Pseudoephedrine page

“Tussi-Organidin DM NR (guaifenesin, hydrocodone, and pseudoephedrine) pairs an opioid cough suppressant with a stimulant decongestant, and that pairing is why its 241-ingredient interaction list warrants genuine care, starting with the 13 rated major. The list pulls in two directions at once.”

Reviewed by 2 · Jul 18, 2026

Open the Guaifenesin, Hydrocodone, Pseudoephedrine interaction page

One more smart check

Taking Ribose as Part of a Dietary Supplement Product? Check It for Interactions

We hold 543 real supplement products containing Ribose, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ribose. Even though Ribose itself has no known interaction with Guaifenesin, Hydrocodone, Pseudoephedrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ribose
Top half

#391 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Guaifenesin, Hydrocodone, Pseudoephedrine
Steady interest

#2,021 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ribose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ribose

What is Ribose?

  • Energy and fatigue
  • Athletic performance and recovery
  • Fibromyalgia symptoms
  • Chronic fatigue
  • Heart-related (cardiac) conditions

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditions, but solid human evidence is limited and mostly small or preliminary. It is generally well tolerated in short-term use, but talk to your pharmacist or doctor before trying it, especially if you have diabetes.

Not applicable (a naturally occurring simple sugar) · Powder, capsules, tablets, drink mixes

An interaction check asks whether these two react with each other — it does not ask whether Ribose is a good idea for someone in your situation. Here is what our Ribose record says about it on its own.

Ribose: dosing

There is no official standardized dose of ribose, and the amounts used in studies have varied widely depending on the goal. Because of this, it is best to follow the directions on the product label.To lower the chance of stomach upset or low blood sugar, some people take it with food and start with a smaller amount.

From our Ribose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ribose monograph & all interactions
Keep checking

Other Drugs & Ribose

Browse every other medication we’ve checked against Ribose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Ribose page.

No interaction 2,743 drugs checked — show the list

We also checked Ribose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Ribose list.

See the full Ribose interactions page
See every supplement checked against Guaifenesin, Hydrocodone, Pseudoephedrine, ranked by severity
Evidence & sources

Ribose References

The 8 references that drive our Ribose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine Together: Common Questions

Is it safe to take Ribose with Guaifenesin, Hydrocodone, Pseudoephedrine?
We do not list a known interaction between Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Ribose and Guaifenesin, Hydrocodone, Pseudoephedrine combination checked?
Interactions in our licensed database are recorded against drug classes. Guaifenesin, Hydrocodone, Pseudoephedrine is filed under 9 classifications, and Ribose has documented interactions with 2 drug classes — none of Guaifenesin, Hydrocodone, Pseudoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ribose interact with any other medications?
Yes. Ribose has 86 documented drug interactions in our database — Guaifenesin, Hydrocodone, Pseudoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Guaifenesin, Hydrocodone, Pseudoephedrine interact with any supplements?
Yes. Guaifenesin, Hydrocodone, Pseudoephedrine has documented interactions with 241 supplements in our database — Ribose is not one of them. The Guaifenesin, Hydrocodone, Pseudoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ribose monograph Uses, safety profile, and every drug interaction in one place Guaifenesin, Hydrocodone, Pseudoephedrine supplement interactions Every supplement checked against Guaifenesin, Hydrocodone, Pseudoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Guaifenesin, Hydrocodone, Pseudoephedrine and Ribose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.