Medication interaction hub

What Supplements Interact with Guaifenesin, Hydrocodone, Pseudoephedrine?

Guaifenesin, Hydrocodone, Pseudoephedrine brand names: Tussi-Organidin DM NR, Entuss-D. Every interaction below applies to the brands too.

241 Interactions 13 Major 190 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guaifenesin, Hydrocodone, Pseudoephedrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guaifenesin, Hydrocodone, Pseudoephedrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tussi-Organidin DM NR (guaifenesin, hydrocodone, and pseudoephedrine) pairs an opioid cough suppressant with a stimulant decongestant, and that pairing is why its 241-ingredient interaction list warrants genuine care, starting with the 13 rated major. The list pulls in two directions at once. Seventy-eight ingredients, alcohol chief among them, deepen hydrocodone's sedation, sometimes to the point of dangerously slowed breathing, while 44 stimulant-type products can drive heart rate and blood pressure up on top of the pseudoephedrine.

Much of the rest is about drug levels. Over a hundred entries can change how the liver clears hydrocodone; grapefruit raises its levels and St. John's wort lowers them, and either shift matters with an opioid. Among the 190 moderate entries are everyday caffeine sources that add jitter to the decongestant side. Minor entries make up the last 38, but the simplest rule here is to skip alcohol entirely while this medicine is in your system.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 190 Minor 38 No known interaction 1,211

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Guaifenesin, Hydrocodone, Pseudoephedrine: Top Interactions at a Glance

The Guaifenesin, Hydrocodone, Pseudoephedrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 241 interacting ingredients — plus 1,211 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Guaifenesin, Hydrocodone, Pseudoephedrine Combinations Today

The Guaifenesin, Hydrocodone, Pseudoephedrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Sida Cordifolia + Guaifenesin, Hydrocodone, Pseudoephedrinei

Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Read the full interaction Moderate Likelihood Possible 5-htp + Guaifenesin, Hydrocodone, Pseudoephedrinei

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Read the full interaction Moderate Likelihood Possible Bacopa + Guaifenesin, Hydrocodone, Pseudoephedrinei

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Yohimbe + Guaifenesin, Hydrocodone, Pseudoephedrinei

Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.

Read the full interaction Moderate Likelihood Possible Lime + Guaifenesin, Hydrocodone, Pseudoephedrinei

Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Read the full interaction Moderate Likelihood Possible Ginkgo + Guaifenesin, Hydrocodone, Pseudoephedrinei

Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Read the full interaction
The complete list

Every Supplement Checked Against Guaifenesin, Hydrocodone, Pseudoephedrine

All 1,452 ingredients in our database, ranked by severity — 241 with a Guaifenesin, Hydrocodone, Pseudoephedrine interaction on file and 1,211 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guaifenesin, Hydrocodone, Pseudoephedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Sida Cordifolia with Guaifenesin, Hydrocodone, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take 5-htp with Guaifenesin, Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Bacopa with Guaifenesin, Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Yohimbe with Guaifenesin, Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.

Full Yohimbe + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Lime with Guaifenesin, Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Aegeline with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Agar with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Algin with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Atractylodes with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Full Atractylodes + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Bael with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Bael + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Black Psyllium with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Blond Psyllium with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Breadfruit with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more i...

Full Breadfruit + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Calea Zacatechichi with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.

Full Calea Zacatechichi + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Carob with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Cascara Sagrada with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.

Full Cascara Sagrada + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Fucus Vesiculosus with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Full Fucus Vesiculosus + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Hemp with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Hibiscus Sabdariffa with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2D6 substrates.

Full Hibiscus Sabdariffa + Guaifenesin, Hydrocodone, Pseudoephedrine answer

Can you take Honey with Guaifenesin, Hydrocodone, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Guaifenesin, Hydrocodone, Pseudoephedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guaifenesin, Hydrocodone, Pseudoephedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guaifenesin, Hydrocodone, Pseudoephedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guaifenesin, Hydrocodone, Pseudoephedrine sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guaifenesin, Hydrocodone, Pseudoephedrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Guaifenesin, Hydrocodone, Pseudoephedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guaifenesin, Hydrocodone, Pseudoephedrine.

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Guaifenesin, Hydrocodone, Pseudoephedrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Guaifenesin, Hydrocodone, Pseudoephedrine.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Guaifenesin, Hydrocodone, Pseudoephedrine & Supplements: Common Questions

What supplements interact with Guaifenesin, Hydrocodone, Pseudoephedrine?
Our database currently documents 241 ingredients with a known Guaifenesin, Hydrocodone, Pseudoephedrine interaction (13 major, 190 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 241. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Guaifenesin, Hydrocodone, Pseudoephedrine supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Guaifenesin, Hydrocodone, Pseudoephedrine?
Plenty of supplements coexist fine with Guaifenesin, Hydrocodone, Pseudoephedrine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tussi-Organidin DM NR have the same supplement interactions as Guaifenesin, Hydrocodone, Pseudoephedrine?
Yes — Tussi-Organidin DM NR, Entuss-D all contain Guaifenesin, Hydrocodone, Pseudoephedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Guaifenesin, Hydrocodone, Pseudoephedrine and my other medications?
This page covers Guaifenesin, Hydrocodone, Pseudoephedrine against supplements and herbal ingredients. Checking Guaifenesin, Hydrocodone, Pseudoephedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.