Osha + Guaifenesin, Hydrocodone, Pseudoephedrine
Guaifenesin, Hydrocodone, Pseudoephedrine brand names: Tussi-Organidin DM NR, Entuss-D.
We found no known interaction between Osha and Guaifenesin, Hydrocodone, Pseudoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Osha and Guaifenesin, Hydrocodone, Pseudoephedrine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Guaifenesin, Hydrocodone, Pseudoephedrine and Osha in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Osha at all — not against Guaifenesin, Hydrocodone, Pseudoephedrine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Osha safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Osha in Pregnancy & Breastfeeding
When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Guaifenesin, Hydrocodone, Pseudoephedrine
This page covers Osha only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guaifenesin, Hydrocodone, Pseudoephedrine page lists 241 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Ephedra (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 13 major · 190 moderate · 38 minor.
From our pharmacist’s overview on the Guaifenesin, Hydrocodone, Pseudoephedrine page
“Tussi-Organidin DM NR (guaifenesin, hydrocodone, and pseudoephedrine) pairs an opioid cough suppressant with a stimulant decongestant, and that pairing is why its 241-ingredient interaction list warrants genuine care, starting with the 13 rated major. The list pulls in two directions at once.”
Reviewed by 2 · Jul 18, 2026
Open the Guaifenesin, Hydrocodone, Pseudoephedrine interaction page
Taking Osha as Part of a Dietary Supplement Product? Check It for Interactions
We hold 336 real supplement products containing Osha, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Osha. Even though Osha itself has no known interaction with Guaifenesin, Hydrocodone, Pseudoephedrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Osha and Guaifenesin, Hydrocodone, Pseudoephedrine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#635 of 1,452 supplements looked up here in the last 7 days
#2,021 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Osha reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Osha and Guaifenesin, Hydrocodone, Pseudoephedrine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Osha
What is Osha?
- Cough and sore throat
- Respiratory infections and colds
- Immune support
- Digestive upset
- Bronchitis and congestion
Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats. Solid human research is lacking, so its benefits remain unproven, and it should be avoided during pregnancy and breastfeeding. Talk to your pharmacist or doctor before trying it.
Ligusticum porteri · Apiaceae · Root · Tea, tincture, capsules, lozenges, chewed raw root
An interaction check asks whether these two react with each other — it does not ask whether Osha is a good idea for someone in your situation. Here is what our Osha record says about it on its own.
Osha: dosing
There is no established standard dose for osha. The right amount depends on the form (tea, tincture, capsule, or lozenge) and the product's strength.If you choose to use osha, follow the directions on the product label and do not exceed them.
From our Osha monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Osha
Browse every other medication we’ve checked against Osha — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Osha against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Letrozole ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Osha list.
Osha References
The 2 references that drive our Osha monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Osha and Guaifenesin, Hydrocodone, Pseudoephedrine Together: Common Questions
Is it safe to take Osha with Guaifenesin, Hydrocodone, Pseudoephedrine?
Does Guaifenesin, Hydrocodone, Pseudoephedrine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.