Drug & supplement interaction

Rose Hip + Isosorbide Mononitrate

Isosorbide Mononitrate brand names: Imdur, Angeze, Dynamin, Elantan, Ismo, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rose Hip and Isosorbide Mononitrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rose Hip and Isosorbide Mononitrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isosorbide Mononitrate and Rose Hip in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rose Hip safety at a glance

Rose Hip overall Use caution Generally well tolerated as a food, but supplement safety is less studied.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated supplements unless your doctor approves.
Breastfeeding Use caution Not enough reliable safety data on supplement doses, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isosorbide Mononitrate and Rose Hip? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Isosorbide Mononitrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Isosorbide Mononitrate is filed under 3 classifications — nitrates, vasodilators, oral drugs. Rose Hip has documented interactions with 8 drug classes — the most serious being alkylating agents (moderate), aluminum (moderate) and anticoagulant/antiplatelet drugs (moderate) — and none of Isosorbide Mononitrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rose Hip Does Interact With Other Medications

Rose Hip has 213 moderate known drug interactions in our database — Isosorbide Mononitrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 213 No known interaction 2,617 (incl. Isosorbide Mononitrate)
Taking anything else?

Check Another of Your Medications Against Rose Hip

Covers the 2,830 medications we’ve checked against Rose Hip. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Rose Hip and Isosorbide Mononitrate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Diarrhea reported in 6.4% of FDA reports for Isosorbide Mononitrate Additional detail

    Rose Hip

    “Orally, gastrointestinal reactions have been reported. These include abdominal cramps, acid reflux, constipation, diarrhea, flatulence, nausea, vomiting, gastrointestinal obstruction, esophagitis, heartburn, acid reflux, and water brash. However, in most cases, these adverse effects occurred at the same frequency in patients taking placebo (15,18104,71641,71646,97938).

    Rose hip powder is a source of vitamin C.”

    Rose Hip · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 18104. Andersson U, Berger K, Hogberg A, et al. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr 2012;66:585-90. PubMed
    3. 71641. Rein, E., Kharazmi, A., and Winther, K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trial. PubMed
    4. 71646. Winther, K., Apel, K., and Thamsborg, G. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34
    5. 97938. Seifi M, Abbasalizadeh S, Mohammad-Alizadeh-Charandabi S, Khodaie L, Mirghafourvand M. The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: a randomized placebo-controlled trial. Phytother Res 2018;32(1):76-83
    6. 4844. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.

    Isosorbide Mononitrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Mononitrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Stomach upset / Constipation / Stomach pain / Nausea / Vomiting reported in 6.2% of FDA reports for Isosorbide Mononitrate Additional detail

    Rose Hip

    Recorded for Rose Hip in the same Natural Medicines adverse-effect record shown under Bloating or gas / Diarrhea above.

    Isosorbide Mononitrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Mononitrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Dizziness / Headache reported in 7.1% of FDA reports for Isosorbide Mononitrate Additional detail

    Rose Hip

    “Orally, vertigo and headache have been reported rarely.”

    Rose Hip · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 97938. Seifi M, Abbasalizadeh S, Mohammad-Alizadeh-Charandabi S, Khodaie L, Mirghafourvand M. The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: a randomized placebo-controlled trial. Phytother Res 2018;32(1):76-83

    Isosorbide Mononitrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Mononitrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Rose Hip but not commonly for Isosorbide Mononitrate: heartburn and hives.

Effects for Isosorbide Mononitrate come from the ADVERSE REACTIONS section of its FDA label; effects for Rose Hip come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 20,621 voluntary FDA FAERS reports for Isosorbide Mononitrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Rose Hip or Isosorbide Mononitrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rose Hip or Isosorbide Mononitrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isosorbide Mononitrate

This page covers Rose Hip only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isosorbide Mononitrate page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Coleus (major), Hawthorn (major) and Beer (moderate).

By severity: 4 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Isosorbide Mononitrate page

“Isosorbide mononitrate (Imdur) is taken daily to prevent angina by keeping blood vessels relaxed, and the 22 supplements and herbs on this page deserve careful reading, not a shrug. Four carry major ratings, and they pull in different directions.”

Reviewed by 2 · Jul 18, 2026

Open the Isosorbide Mononitrate interaction page

One more smart check

Taking Rose Hip as Part of a Dietary Supplement Product? Check It for Interactions

We hold 273 real supplement products containing Rose Hip, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rose Hip. Even though Rose Hip itself has no known interaction with Isosorbide Mononitrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rose Hip and Isosorbide Mononitrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rose Hip
Top half

#373 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isosorbide Mononitrate
Steady interest

#2,537 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rose Hip reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rose Hip and Isosorbide Mononitrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rose Hip

What is Rose Hip?

Rose Hip
  • Joint pain and osteoarthritis
  • Colds and flu
  • Source of vitamin C
  • Digestive complaints
  • Anti-inflammatory support

Rose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research support for easing osteoarthritis symptoms, but evidence for most other uses is limited. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using it as a supplement.

Rosa canina · Rosaceae · Fruit (hips), including the seeds and outer flesh · Tea, capsules, tablets, powder, syrup, dried fruit, extracts

An interaction check asks whether these two react with each other — it does not ask whether Rose Hip is a good idea for someone in your situation. Here is what our Rose Hip record says about it on its own.

Rose Hip: dosing

There is no single official dose for rose hip. The amount used in osteoarthritis research has been a standardized powder taken daily, but products on the market vary widely in strength and vitamin C content.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Rose Hip monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rose Hip monograph & all interactions
Medication

About Isosorbide

What Is Isosorbide Used For?

Brand names: Imdur, Angeze, Dynamin, Elantan, Ismo, Chemydur 60XL, Elantan LA, Isib 60XL, Ismo Retard, Isodur, Isotard, Modisal LA, Modisal XL, Monomax SR, Monomax XL, Angeze SR, Monomil XL, Monosorb XL, Zemon

Isosorbide is used to prevent angina pectoris — chest pain or tightness caused by coronary artery disease. Both isosorbide dinitrate tablets and isosorbide mononitrate tablets (including Monoket and Isordil) are used for this purpose.

Important: none of these oral formulations work fast enough to stop a chest pain episode that has already started. They are taken on a schedule to prevent angina, not to treat it in the moment.

Most-Reported Side Effects for Isosorbide Mononitrate

From FAERS, the FDA’s public side-effect reporting system (20,621 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,568 reports
Dizziness 1,464 reports
Fatigue 1,314 reports
Diarrhea 1,311 reports
Nausea 1,284 reports
See full Isosorbide drug information
Keep checking

Other Drugs & Rose Hip

Browse every other medication we’ve checked against Rose Hip — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
213Moderate
0Minor
2,616No known interaction
213 Moderate 2,616 No interaction
Moderate

213 interactions

Showing 60 of 213 moderate interactions — see all 213 on the Rose Hip page.

No interaction 2,616 drugs checked — show the list

We also checked Rose Hip against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,616 medications checked with no known interaction — see the full Rose Hip list.

See the full Rose Hip interactions page
See every supplement checked against Isosorbide Mononitrate, ranked by severity
Evidence & sources

Rose Hip References

The 24 references that drive our Rose Hip monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  5. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  6. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  9. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  10. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  11. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  12. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  13. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  14. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  15. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rose Hip and Isosorbide Mononitrate Together: Common Questions

Is it safe to take Rose Hip with Isosorbide Mononitrate?
We do not list a known interaction between Rose Hip and Isosorbide Mononitrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rose Hip and Isosorbide Mononitrate have any of the same side effects?
Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Rose Hip and Isosorbide Mononitrate combination checked?
Interactions in our licensed database are recorded against drug classes. Isosorbide Mononitrate is filed under 3 classifications, and Rose Hip has documented interactions with 8 drug classes — none of Isosorbide Mononitrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rose Hip interact with any other medications?
Yes. Rose Hip has 213 documented drug interactions in our database — Isosorbide Mononitrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Isosorbide Mononitrate interact with any supplements?
Yes. Isosorbide Mononitrate has documented interactions with 22 supplements in our database — Rose Hip is not one of them. The Isosorbide Mononitrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rose Hip monograph Uses, safety profile, and every drug interaction in one place Isosorbide drug information The full plain-English guide to this medication Isosorbide Mononitrate supplement interactions Every supplement checked against Isosorbide Mononitrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isosorbide Mononitrate and Rose Hip?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.