Drug & supplement interaction

Rusty-leaved Rhododendron + Rilpivirine

Rilpivirine brand names: Edurant, Edurant Ped.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Rusty-leaved Rhododendron and Rilpivirine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Rilpivirine states a food rule worth keeping to.

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Interaction report

Rusty-leaved Rhododendron and Rilpivirine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rilpivirine and Rusty-leaved Rhododendron in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Rusty-leaved Rhododendron at all — not against Rilpivirine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rusty-leaved Rhododendron safety at a glance

Rusty-leaved Rhodo... overall Use caution Limited safety data and risk of toxic look-alike species mean it should be used cautiously.
Pregnancy Possibly Unsafe When used orally. Rusty-leaved rhododendron might be poisonous; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Rusty-leaved rhododendron might be poisonous; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rilpivirine and Rusty-leaved Rhododendron? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Rusty-leaved Rhododendron Itself Has Been Linked To

This is not an interaction — nothing below involves Rilpivirine. It is the side-effect record for Rusty-leaved Rhododendron on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Rusty-leaved Rhododendron, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A slow heartbeat / Fainting / Seizures Worth acting on Additional detail

    “There is currently no information on the adverse effects of rusty-leaved rhododendron. A related species, Rhododendron ponticum, can cause weakness, dizziness, nausea, vomiting, hypotension, bradycardia, transient A-V dissociation and blurred vision (18,3496).”

    Rusty-leaved Rhododendron · Natural Medicines adverse-effect record, reported in epilepsy.

    5 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 3496. Biberoglu S, Biberoglu K, Komsuoglu B. Mad honey. [Letter to the Editor] JAMA 1988;259:1943.
    3. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    4. 3477. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
    5. 100643. Louis A, Petereit F, Lechtenberg M, Deters A, Hensel A. Phytochemical characterization of Rhododendron ferrugineum and in vitro assessment of an aqueous extract on cell toxicity. Planta Med 2010;76(14):1550-7. doi: 10.1055/s-0029-1241016.
  • Chills / Blurred vision / Sweating / Low blood pressure / Dizziness / Vomiting / Nausea Additional detail

    Recorded for Rusty-leaved Rhododendron in the same Natural Medicines adverse-effect record shown under A slow heartbeat / Fainting / Seizures above.

Everything above comes from the Natural Medicines adverse-effect record for Rusty-leaved Rhododendron — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Rilpivirine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Rilpivirine column appears here.

Special populations

Rusty-leaved Rhododendron in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Rusty-leaved rhododendron might be poisonous; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Rilpivirine Products Have a Food Rule — Rusty-leaved Rhododendron Should Not Break It

At least one FDA label for a product containing Rilpivirine says to take it with food. If you take Rusty-leaved Rhododendron on an empty stomach out of habit, keep them separate — and take Rilpivirine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Rilpivirine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION One 25 mg rilpivirine tablet taken once daily with a meal for patients weighing at least 35 kg.

From the Dosage and Administration section of the FDA label we read for Rilpivirine — where that label names a specific product, the instruction is that product's. See the Rilpivirine drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Rilpivirine

This page covers Rusty-leaved Rhododendron only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rilpivirine page lists 175 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 127 moderate · 37 minor.

From our pharmacist’s overview on the Rilpivirine page

“St. John's wort is the supplement I would rule out first for anyone taking rilpivirine (Edurant) for HIV.”

Reviewed by 2 · Jul 18, 2026

Open the Rilpivirine interaction page

How much people look this up

Where Rusty-leaved Rhododendron and Rilpivirine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rusty-leaved Rhododendron
Steady interest

#1,410 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rilpivirine
Steady interest

#2,222 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rusty-leaved Rhododendron reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rusty-leaved Rhododendron and Rilpivirine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rusty-leaved Rhododendron

What is Rusty-leaved Rhododendron?

  • Joint and muscle pain
  • Gout and rheumatic complaints
  • High blood pressure (folk use)
  • General aches and pains

Rusty-leaved rhododendron is an alpine shrub used in traditional European medicine for pain and rheumatic complaints, but there is very little human research to support these uses. Because rhododendron species can contain toxic compounds and are easily confused with one another, it is best to use this plant only with professional guidance and to avoid it during pregnancy and breastfeeding.

Rhododendron ferrugineum · Ericaceae · Leaves and flowers · Tea, tincture, dried herb, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Rusty-leaved Rhododendron is a good idea for someone in your situation. Here is what our Rusty-leaved Rhododendron record says about it on its own.

Rusty-leaved Rhododendron: dosing

There is no established or standardized safe dose for rusty-leaved rhododendron. Because the plant can contain toxic compounds and because amounts vary from plant to plant, it is not possible to recommend a specific dose.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Rusty-leaved Rhododendron monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rusty-leaved Rhododendron monograph & all interactions
Medication

About Rilpivirine

What Is Rilpivirine Used For?

Brand names: Edurant, Edurant Ped

Rilpivirine tablets (sold as Edurant, Edurant Ped, and generic rilpivirine) are used along with other antiretroviral medicines to treat HIV-1 infection in patients who have not previously been treated with HIV medicines (treatment-naïve). Eligibility depends on age, body weight, and the level of virus in the blood at the start of treatment.

Edurant tablets are also approved, in combination with cabotegravir (Vocabria), for short-term oral use in adults and adolescents who are already virologically suppressed — specifically as a lead-in before starting the long-acting injectable regimen Cabenuva, or as a bridge if a Cabenuva injection dose will be missed.

Most-Reported Side Effects for Rilpivirine

From FAERS, the FDA’s public side-effect reporting system (24,864 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Bone density decreased 4,430 reports
Renal injury 3,215 reports
Skeletal injury 2,981 reports
Chronic kidney disease 2,716 reports
Tooth loss 2,413 reports
See full Rilpivirine drug information
Keep checking

Other Drugs & Rusty-leaved Rhododendron

Browse every other medication we’ve checked against Rusty-leaved Rhododendron — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Rusty-leaved Rhododendron References

The 6 references that drive our Rusty-leaved Rhododendron monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Furbee B, Wermuth M. Life-threatening plant poisoning. Crit Care Clin 1997;13:849-88. PubMed
  5. Biberoglu S, Biberoglu K, Komsuoglu B. Mad honey. [Letter to the Editor] JAMA 1988;259:1943.
  6. Louis A, Petereit F, Lechtenberg M, Deters A, Hensel A. Phytochemical characterization of Rhododendron ferrugineum and in vitro assessment of an aqueous extract on cell toxicity. Planta Med 2010;76(14):1550-7. doi: 10.1055/s-0029-1241016.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rusty-leaved Rhododendron and Rilpivirine Together: Common Questions

Is it safe to take Rusty-leaved Rhododendron with Rilpivirine?
We do not list a known interaction between Rusty-leaved Rhododendron and Rilpivirine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Rusty-leaved Rhododendron and Rilpivirine at the same time of day?
At least one FDA label for a product containing Rilpivirine says to take it with food. If you take Rusty-leaved Rhododendron on an empty stomach out of habit, keep them separate and take Rilpivirine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Rilpivirine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Rilpivirine interact with any supplements?
Yes. Rilpivirine has documented interactions with 175 supplements in our database — Rusty-leaved Rhododendron is not one of them. The Rilpivirine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Rilpivirine and Rusty-leaved Rhododendron?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.