Drug & supplement interaction

S-23 + Ursodiol

Ursodiol brand name: Actigall.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between S-23 and Ursodiol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

S-23 and Ursodiol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ursodiol and S-23 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for S-23 at all — not against Ursodiol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

S-23 safety at a glance

S-23 overall Avoid S-23 is an unapproved experimental drug with no human safety data and known hormonal risks.
Pregnancy Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ursodiol and S-23? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ursodiol’s Own FDA Label Lists

This is not an interaction — none of it involves S-23. These are the most notable effects listed in the ADVERSE REACTIONS section of Ursodiol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Chest pain Worth acting on
  • A higher chance of infection Worth acting on
  • Bloating or gas
  • Hair loss
  • A stuffy or runny nose
  • Sore throat
  • Back pain
  • Cough
  • Joint pain
  • Muscle pain

Showing the 10 most notable of 20 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ursodiol. Read the label on DailyMed › S-23’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no S-23 side to compare — that is a limit of the record, not a statement that S-23 has no side effects.

Special populations

S-23 in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modulators (SARMs) are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About S-23 or Ursodiol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers S-23 or Ursodiol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ursodiol

This page covers S-23 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ursodiol page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Ursodiol page

“Ursodiol (Actigall) has to be absorbed to do its job, whether that job is dissolving gallstones or protecting a liver with primary biliary cholangitis, and all 17 supplements on this page can interfere with exactly that. I'd treat these pairings with genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Ursodiol interaction page

One more smart check

Taking S-23 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 5 real supplement products containing S-23, each one broken down to its full ingredient list — and combination products often carry several ingredients besides S-23. Even though S-23 itself has no known interaction with Ursodiol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where S-23 and Ursodiol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement S-23
Steady interest

#1,009 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ursodiol
Top half

#1,409 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every S-23 reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The S-23 and Ursodiol records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About S-23

What is S-23?

  • Muscle building
  • Fat loss
  • Athletic performance enhancement
  • Body recomposition
  • Investigational male contraceptive (research only)

S-23 is an experimental, non-prescription synthetic drug called a selective androgen receptor modulator (SARM), not a dietary supplement, herb, or natural product. It has never been approved for human use, has not been proven safe in people, and is banned in sports; we do not recommend using it.

Not applicable; S-23 is a synthetic chemical compound · Liquid solutions, capsules, and powders sold as 'research chemicals'

An interaction check asks whether these two react with each other — it does not ask whether S-23 is a good idea for someone in your situation. Here is what our S-23 record says about it on its own.

S-23: dosing

There is no established or safe dose of S-23 for humans. It has never gone through the clinical testing that would set a safe and effective dose, so any amounts shared online are unverified and potentially dangerous.We do not provide dosing guidance for S-23 because doing so could imply it is safe to use, which it is not.

From our S-23 monograph — the full record covers uses, side effects and every documented interaction.

Read the full S-23 monograph & all interactions
Medication

About Ursodiol

What Is Ursodiol Used For?

Brand name: Actigall

Ursodiol capsules (including Reltone, Ursolign, and generic ursodiol capsules) are used to dissolve certain types of gallstones — specifically small, non-calcified cholesterol stones — in people who cannot have or prefer not to have gallbladder surgery. Capsules are also used to prevent gallstones from forming in people who are losing weight rapidly.

Ursodiol tablets — including Urso 250, Urso Forte, and generic ursodiol tablets — are indicated for the treatment of primary biliary cholangitis (PBC), a chronic liver disease that damages the bile ducts inside the liver.

Most-Reported Side Effects for Ursodiol

From FAERS, the FDA’s public side-effect reporting system (21,651 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 1,299 reports
Diarrhea 1,223 reports
Fatigue 1,093 reports
Nausea 1,062 reports
Fever 990 reports
See full Ursodiol drug information
Keep checking

Other Drugs & S-23

Browse every other medication we’ve checked against S-23 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked S-23 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full S-23 list.

See the full S-23 interactions page
See every supplement checked against Ursodiol, ranked by severity
Evidence & sources

S-23 References

The 1 references that drive our S-23 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking S-23 and Ursodiol Together: Common Questions

Is it safe to take S-23 with Ursodiol?
We do not list a known interaction between S-23 and Ursodiol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ursodiol interact with any supplements?
Yes. Ursodiol has documented interactions with 17 supplements in our database — S-23 is not one of them. The Ursodiol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

S-23 monograph Uses, safety profile, and every drug interaction in one place Ursodiol drug information The full plain-English guide to this medication Ursodiol supplement interactions Every supplement checked against Ursodiol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ursodiol and S-23?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.