Drug & supplement interaction

Samphire + Nadolol

Nadolol brand names: Corgard, Nadolol.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Samphire and Nadolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Samphire and Nadolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nadolol and Samphire in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Samphire at all — not against Nadolol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Samphire safety at a glance

Samphire overall Use caution Generally safe as a food, but it can be high in sodium and is poorly studied as a supplement.
Pregnancy Use caution Likely fine in normal food amounts, but avoid concentrated supplements due to lack of safety data.
Breastfeeding Use caution Food amounts are probably okay, but supplement-strength products have not been studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nadolol and Samphire? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Nadolol’s Own FDA Label Lists

This is not an interaction — none of it involves Samphire. These are the most notable effects listed in the ADVERSE REACTIONS section of Nadolol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Memory problems Worth acting on
  • A slow heartbeat Worth acting on
  • Blood clots Worth acting on
  • Hallucinations Worth acting on
  • Heart failure Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Low mood Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on

Showing the 10 most notable of 41 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed › Where a percentage is shown, it is the share of 7,530 voluntary FDA FAERS reports for Nadolol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Samphire’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Samphire side to compare — that is a limit of the record, not a statement that Samphire has no side effects.

Everything else you take

See Every Supplement That Interacts With Nadolol

This page covers Samphire only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nadolol page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Green Tea (major) and Indian Snakeroot (major).

By severity: 6 major · 119 moderate · 20 minor.

From our pharmacist’s overview on the Nadolol page

“If you take nadolol (Corgard) for blood pressure, angina, or heart rhythm, treat this list with real care, and green tea is the surprise at the top. In a clinical study, green tea cut nadolol blood levels by roughly 85 percent, which can quietly leave you undertreated.”

Reviewed by 2 · Jul 18, 2026

Open the Nadolol interaction page

One more smart check

Taking Samphire as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Samphire, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Samphire. Even though Samphire itself has no known interaction with Nadolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Samphire and Nadolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Samphire
Steady interest

#1,234 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nadolol
Top half

#1,005 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Samphire is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Samphire reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Samphire and Nadolol records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Samphire

What is Samphire?

  • Culinary vegetable and seasoning
  • Source of vitamins and minerals
  • Digestive health
  • Traditional skin and antioxidant uses
  • Salt substitute or low-sodium flavoring

Samphire is a salt-tolerant coastal plant eaten as a vegetable, prized for its crisp, salty taste and its nutrients like vitamins and minerals. There is very little human research supporting any specific health benefit beyond its value as a food, so it should be enjoyed mainly as a food rather than relied on as a medicine. If you are pregnant, breastfeeding, or watching your salt intake, talk to a pharmacist or doctor first.

Young stems and leaves (sometimes the whole above-ground plant) · Fresh vegetable, pickled, dried, powder, and occasionally as an extract

An interaction check asks whether these two react with each other — it does not ask whether Samphire is a good idea for someone in your situation. Here is what our Samphire record says about it on its own.

Samphire: dosing

There is no established medicinal dose for samphire. As a food, people simply eat it as a vegetable in normal portions.

From our Samphire monograph — the full record covers uses, side effects and every documented interaction.

Read the full Samphire monograph & all interactions
Medication

About Nadolol

What Is Nadolol Used For?

Brand names: Corgard, Nadolol

Nadolol tablets are used for two main conditions: high blood pressure (hypertension) and angina pectoris (ongoing chest pain caused by reduced blood flow to the heart). Lowering high blood pressure reduces the risk of stroke and heart attack.

For high blood pressure, nadolol may be prescribed on its own or combined with other blood pressure medications, especially thiazide-type diuretics (water pills). For angina, it is used for long-term management to help reduce how often chest pain occurs.

Most-Reported Side Effects for Nadolol

From FAERS, the FDA’s public side-effect reporting system (7,530 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Macular degeneration 831 reports
Nausea 673 reports
Headache 603 reports
Fatigue 526 reports
Weight decreased 464 reports
See full Nadolol drug information
Keep checking

Other Drugs & Samphire

Browse every other medication we’ve checked against Samphire — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Samphire against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Samphire list.

See the full Samphire interactions page
See every supplement checked against Nadolol, ranked by severity
Evidence & sources

Samphire References

The 3 sources that drive our Samphire monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Samphire is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Sodium in Your Diet — U.S. Food and Drug Administration (FDA) Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Herbal Supplements — MedlinePlus (NIH) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Samphire and Nadolol Together: Common Questions

Is it safe to take Samphire with Nadolol?
We do not list a known interaction between Samphire and Nadolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Nadolol interact with any supplements?
Yes. Nadolol has documented interactions with 145 supplements in our database — Samphire is not one of them. The Nadolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Samphire monograph Uses, safety profile, and every drug interaction in one place Nadolol drug information The full plain-English guide to this medication Nadolol supplement interactions Every supplement checked against Nadolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nadolol and Samphire?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.