Drug & supplement interaction

Serine + Diclofenac Sodium

Diclofenac Sodium brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Serine and Diclofenac Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Serine and Diclofenac Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac Sodium and Serine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Serine at all — not against Diclofenac Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Serine safety at a glance

Serine overall Use caution Generally considered low-risk in food amounts, but supplement safety and long-term use are not well established.
Pregnancy Avoid There is not enough safety data on supplemental serine in pregnancy, so it is best avoided unless your doctor advises it.
Breastfeeding Avoid Safety during breastfeeding has not been studied, so avoid supplements unless directed by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac Sodium and Serine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Serine and Diclofenac Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Serine

    “Orally, D-serine 120 mg/kg (about 8 grams) daily has been reported to cause insomnia after a single dose. Taking L-serine in doses greater than 400 mg/kg (about 25 grams) can cause reversible nystagmus and seizures.”

    Serine · Natural Medicines adverse-effect record, reported in epilepsy.

    2 sources cited
    1. 102215. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
    2. 102204. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    Serine

    “Orally, D-serine 120 mg/kg (about 8 grams) daily for 4 weeks has been reported to cause proteinuria without glycosuria or creatine elevation. Proteinuria resolved completely after discontinuation of serine.”

    Serine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 102215. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Serine

    “Orally, D-serine 120 mg/kg (about 8 grams) daily has been reported to cause asymptomatic transaminitis which resolved after discontinuation of serine.”

    Serine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 102215. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • A higher chance of infection Worth acting on Additional detail

    Serine

    “Orally, in one very small, exploratory study, patients taking L-serine 400 mg/kg (about 25 grams) daily for one year had a higher rate of localized infections than those taking placebo. Whether ingestion of L-serine caused or increased the risk of these infections is unknown.”

    Serine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 102204. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • Bloating or gas / Stomach upset / Stomach pain / Nausea reported in 6.2% of FDA reports for Diclofenac Sodium Additional detail

    Serine

    “Orally, D-serine 120 mg/kg (about 8 grams) daily has been reported to cause gastrointestinal distress. L-serine 5-30 grams daily has been reported to cause abdominal pain, dyspepsia, bloating, nausea, and loss of appetite.”

    Serine · Natural Medicines adverse-effect record, reported in dyspepsia.

    3 sources cited
    1. 102215. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
    2. 102204. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
    3. 102220. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Trouble sleeping Additional detail

    Serine

    Recorded for Serine in the same Natural Medicines adverse-effect record shown under Seizures above.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

Reported for Serine but not commonly for Diclofenac Sodium: reduced appetite.

Effects for Diclofenac Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Serine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 155,962 voluntary FDA FAERS reports for Diclofenac Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Serine or Diclofenac Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Serine or Diclofenac Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac Sodium

This page covers Serine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac Sodium page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 266 moderate · 35 minor.

From our pharmacist’s overview on the Diclofenac Sodium page

“Diclofenac (Voltaren), a daily mainstay for arthritis and joint pain, comes with a supplement list that calls for real vigilance. Of the 308 ingredients on file, 7 rate major, and roughly two hundred entries share a single theme: anything with blood-thinning activity adds to diclofenac's own bleeding risk, especially in the stomach.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac Sodium interaction page

One more smart check

Taking Serine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 898 real supplement products containing Serine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Serine. Even though Serine itself has no known interaction with Diclofenac Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Serine and Diclofenac Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Serine
Top 25%

#292 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac Sodium
Top 10%

#276 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Serine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Serine and Diclofenac Sodium records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Serine

What is Serine?

  • Memory and brain health
  • Nervous system disorders (e.g., ALS research)
  • Mood and stress support
  • Sleep support
  • General supplementation for the nervous system

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has been studied for certain neurological conditions like ALS, but the evidence is still early and far from proven. If you are considering a serine supplement, talk with your pharmacist or doctor first.

Amino acid (made by the body and found in protein foods) · Capsules, powder, tablets; available as L-serine and phosphatidylserine

An interaction check asks whether these two react with each other — it does not ask whether Serine is a good idea for someone in your situation. Here is what our Serine record says about it on its own.

Serine: dosing

There is no well-established standard dose of serine for general supplement use. Doses used in research, especially for neurological conditions, vary widely and were given under medical supervision, so they should not be copied at home.If you choose to take a serine product, follow the directions on the label and do not exceed the recommended amount.

From our Serine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Serine monograph & all interactions
Medication

About Diclofenac

What Is Diclofenac Used For?

Brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, Diclo SR, Voltarol, Acoflam, Defenac, Dicloflex, Diclovol, Diclozip, Fenactol, Flamrase, Volraman, Diclomax SR, Diclomax Retard, Motifene 75 mg, Voltarol 75 mg SR, Acoflam 75 SR, Defenac SR, Dexomon 75 SR, Dicloflex 75 SR, Diclovol SR, Fenactol 75 mg SR, Flamatak 75 MR, Flamrase SR, Flexotard MR 75, Rheumatac Retard 75, Rhumalgan CR, Slofenac SR, Volsaid Retard 75, Voltarol Retard, Acoflam Retard, Defenac Retard, Dexomon Retard 100, Dicloflex Retard, Diclovol Retard, Fenactol Retard 100 mg, Flamatak 100 MR, Volsaid Retard 100, Voltarol Ophtha Multidose, Voltarol Ophtha, Pennsaid, Voltaren Emulgel, Dyloject

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

Most-Reported Side Effects for Diclofenac Sodium

From FAERS, the FDA’s public side-effect reporting system (155,962 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,844 reports
Arthralgia 11,333 reports
Rash 10,855 reports
Rheumatoid arthritis 10,744 reports
Abdominal discomfort 9,636 reports
See full Diclofenac drug information
Keep checking

Other Drugs & Serine

Browse every other medication we’ve checked against Serine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Serine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Serine list.

See the full Serine interactions page
See every supplement checked against Diclofenac Sodium, ranked by severity
Evidence & sources

Serine References

The 3 references that drive our Serine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Serine and Diclofenac Sodium Together: Common Questions

Is it safe to take Serine with Diclofenac Sodium?
We do not list a known interaction between Serine and Diclofenac Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Serine and Diclofenac Sodium have any of the same side effects?
Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Diclofenac Sodium interact with any supplements?
Yes. Diclofenac Sodium has documented interactions with 308 supplements in our database — Serine is not one of them. The Diclofenac Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Serine monograph Uses, safety profile, and every drug interaction in one place Diclofenac drug information The full plain-English guide to this medication Diclofenac Sodium supplement interactions Every supplement checked against Diclofenac Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac Sodium and Serine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.