Drug & supplement interaction

Siberian Cocklebur + Evinacumab-Dgnb

Evinacumab-Dgnb brand name: Evkeeza.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Siberian Cocklebur and Evinacumab-Dgnb in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Siberian Cocklebur and Evinacumab-Dgnb

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Evinacumab-Dgnb and Siberian Cocklebur in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Siberian Cocklebur safety at a glance

Siberian Cocklebur overall Use caution The fruit contains toxic compounds and has caused serious poisoning, so it requires careful processing and professional oversight.
Pregnancy Likely Unsafe When the seeds and seedlings of Siberian cocklebur are used orally. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the seeds and seedlings of Siberian cocklebur are used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Evinacumab-Dgnb and Siberian Cocklebur? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Siberian Cocklebur Does Interact With Other Medications

Siberian Cocklebur has 662 major, known drug interactions in our database — Evinacumab-Dgnb isn’t one of them. If you take anything else, check it against the full list below.

Major 662 No known interaction 2,168 (incl. Evinacumab-Dgnb)
Taking anything else?

Check Another of Your Medications Against Siberian Cocklebur

Covers the 2,830 medications we’ve checked against Siberian Cocklebur. Pick one to open its full report.

What to actually watch for

What Siberian Cocklebur Itself Has Been Linked To

This is not an interaction — nothing below involves Evinacumab-Dgnb. It is the side-effect record for Siberian Cocklebur on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Siberian Cocklebur, this list is the first place to look. 9 entries are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on Additional detail

    “Orally, Siberian cocklebur seedlings and seeds can cause rhabdomyolysis. White blood cell infiltration in the muscles has been reported in autopsy findings from patients who died after consuming Siberian cocklebur.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in muscle breakdown.

    1 source cited
    1. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  • Low blood sugar / Seizures Worth acting on Additional detail

    “Siberian cocklebur is generally regarded as unsafe for use. Any benefits of therapy might not outweigh the risk of toxicity. Orally, Siberian cocklebur seeds and seedlings can cause various adverse effects. Initial effects include abdominal pain, nausea, vomiting, hypoglycemia, elevated liver function tests, increased risk of bleeding, drowsiness, dizziness, dyspnea, sweating, fever, and palpitations.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in arrhythmia.

    4 sources cited
    1. 27827. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
    2. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
    3. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
    4. 27815. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI

    “Orally, Siberian cocklebur seedlings and seeds can cause hypoglycemia. This occurs soon after consumption. Later, metabolic acidosis, hyperglycemia, and/or worsening hypoglycemia might occur. In some individuals, these changes can cause seizures.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in epilepsy.

    2 sources cited
    1. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
    2. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
  • A slow heartbeat Worth acting on Additional detail

    “Orally, Siberian cocklebur seed can cause both tachycardia and bradycardia. Palpitations can occur in as little as 3 hours after ingestion, with arrhythmia occurring a few hours later. Elevated heart enzymes can also occur soon after intake. White blood cell infiltration in the myocardium has been reported in autopsy findings from patients who died after consuming Siberian cocklebur.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
    2. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
  • Pancreatitis Worth acting on Additional detail

    “Orally, Siberian cocklebur seedlings and seeds can cause abdominal pain, nausea, and vomiting. Gastrointestinal symptoms occur within a few hours after consumption. In one case, pancreatitis occurred approximately 2 days after intake of the seeds in a 15-year-old girl.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
  • Yellowing of the skin or eyes Worth acting on Additional detail

    “Orally, Siberian cocklebur seedlings and seeds can cause liver damage, including increased bilirubin levels and increases in liver enzyme levels by as much as 6 times the normal value. These symptoms can progress to include jaundice, hepatomegaly, and edema, resulting in liver failure and death in some patients.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in liver transplant.

    4 sources cited
    1. 27827. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
    2. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
    3. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
    4. 27815. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  • High blood sugar Worth acting on Additional detail

    Recorded for Siberian Cocklebur in the same Natural Medicines adverse-effect record shown under Low blood sugar / Seizures above.

  • An irregular heartbeat Worth acting on Additional detail

    Recorded for Siberian Cocklebur in the same Natural Medicines adverse-effect record shown under Low blood sugar / Seizures above.

  • Confusion Worth acting on Additional detail

    “Orally, Siberian cocklebur seedlings and seeds can cause altered mental status, malaise, dizziness, sweating, fever, seizures, convulsions, unconsciousness, and coma. Malaise, dizziness, and sweating onset are rapid. Fever onset is usually after the onset of vomiting. Unconsciousness can follow vomiting within minutes or hours, with coma occurring later in some individuals.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in epilepsy.

    3 sources cited
    1. 27827. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
    2. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
    3. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.
  • Kidney problems Worth acting on Additional detail

    “Orally, Siberian cocklebur seedlings and seeds have resulted in cases of renal injury with increased levels of creatinine and blood urea nitrogen. This can result in decreased urine output. In some individuals, renal symptoms return to normal. However, renal failure can occur and renal proximal tubular necrosis has been reported in autopsy findings for patients who died after consuming Siberian cocklebur.”

    Siberian Cocklebur · Natural Medicines adverse-effect record, reported in kidney failure.

    2 sources cited
    1. 27828. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
    2. 99948. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

Showing the 10 most notable of 23 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Siberian Cocklebur — expand a row for the licensed statement it rests on. We haven’t matched Evinacumab-Dgnb to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Evinacumab-Dgnb.

Special populations

Siberian Cocklebur in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the seeds and seedlings of Siberian cocklebur are used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Siberian Cocklebur as Part of a Dietary Supplement Product? Check It for Interactions

We hold 84 real supplement products containing Siberian Cocklebur, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Siberian Cocklebur. Even though Siberian Cocklebur itself has no known interaction with Evinacumab-Dgnb, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Siberian Cocklebur and Evinacumab-Dgnb Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Siberian Cocklebur
Top half

#476 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Evinacumab-Dgnb
Top half

#1,100 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Siberian Cocklebur reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Siberian Cocklebur and Evinacumab-Dgnb records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Siberian Cocklebur

What is Siberian Cocklebur?

  • Nasal congestion and sinus problems
  • Allergic rhinitis (hay fever)
  • Headache
  • Skin conditions and itching
  • Joint and muscle discomfort

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the plant contains naturally toxic compounds that can cause serious poisoning, so it should only be used under expert guidance, if at all.

Xanthium sibiricum · Asteraceae · Fruit (burr), sometimes leaves and aerial parts · Dried fruit, decoctions (teas), powders, capsules, traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Siberian Cocklebur is a good idea for someone in your situation. Here is what our Siberian Cocklebur record says about it on its own.

Siberian Cocklebur: dosing

There is no well-established standardized dose for Siberian cocklebur, and dosing in traditional medicine depends on the specific preparation and formula used. Because of the toxicity risk, the difference between a traditional dose and a harmful one can be small.Do not self-dose with this herb. If you are considering it, only use products from a reputable source and follow the directions of a qualified practitioner.

From our Siberian Cocklebur monograph — the full record covers uses, side effects and every documented interaction.

Read the full Siberian Cocklebur monograph & all interactions
Medication

About Evinacumab-dgnb Injection

What Is Evinacumab-dgnb Injection Used For?

Brand name: Evkeeza

  • Evinacumab-dgnb is used in combination with other treatments to reduce the amount low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and other fatty substances in the blood in adults and children 12 years of age or older that have homozygous familial hypercholesterolemia (HoFH; an inherited condition in which cholesterol cannot be removed from the body normally). Evinacumab-dgnb is in a class of medications called angiopoietin-like protein 3 (ANGPTL3) inhibitor monoclonal antibodies. It works by decreasing the production of LDL cholesterol and increasing the breakdown of LDL cholesterol and other fatty substances in the body.

  • Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats may help prevent heart disease, angina (chest pain), strokes, and heart attacks.

See full Evinacumab-dgnb Injection drug information
Keep checking

Other Drugs & Siberian Cocklebur

Browse every other medication we’ve checked against Siberian Cocklebur — both the ones with a known interaction and the ones without. Select any drug for the full detail.

662Major
0Moderate
0Minor
2,167No known interaction
662 Major 2,167 No interaction
Major

662 interactions

Showing 60 of 662 major interactions — see all 662 on the Siberian Cocklebur page.

No interaction 2,167 drugs checked — show the list

We also checked Siberian Cocklebur against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,167 medications checked with no known interaction — see the full Siberian Cocklebur list.

See the full Siberian Cocklebur interactions page
See every supplement checked against Evinacumab-Dgnb, ranked by severity
Evidence & sources

Siberian Cocklebur References

The 4 references that drive our Siberian Cocklebur monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Siberian Cocklebur and Evinacumab-Dgnb Together: Common Questions

Is it safe to take Siberian Cocklebur with Evinacumab-Dgnb?
We do not list a known interaction between Siberian Cocklebur and Evinacumab-Dgnb. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Siberian Cocklebur interact with any other medications?
Yes. Siberian Cocklebur has 662 documented drug interactions in our database — Evinacumab-Dgnb is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Siberian Cocklebur monograph Uses, safety profile, and every drug interaction in one place Evinacumab-dgnb Injection drug information The full plain-English guide to this medication Evinacumab-Dgnb supplement interactions Every supplement checked against Evinacumab-Dgnb, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Evinacumab-Dgnb and Siberian Cocklebur?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.