Drug & supplement interaction

Smartweed + Cobimetinib Fumarate

Cobimetinib Fumarate brand name: Cotellic.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Smartweed and Cobimetinib Fumarate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Smartweed and Cobimetinib Fumarate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cobimetinib Fumarate and Smartweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Smartweed safety at a glance

Smartweed overall Use caution There is little modern safety data, so use cautiously and talk to a healthcare provider first.
Pregnancy Avoid Traditionally used to affect menstruation and the uterus, so avoid during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cobimetinib Fumarate and Smartweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cobimetinib Fumarate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cobimetinib Fumarate is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Smartweed has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Cobimetinib Fumarate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Smartweed Does Interact With Other Medications

Smartweed has 2 moderate known drug interactions in our database — Cobimetinib Fumarate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Cobimetinib Fumarate)
Taking anything else?

Check Another of Your Medications Against Smartweed

Covers the 2,830 medications we’ve checked against Smartweed. Pick one to open its full report.

What to actually watch for

What Cobimetinib Fumarate’s Own FDA Label Lists

This is not an interaction — none of it involves Smartweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Cobimetinib Fumarate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on
  • Low sodium Worth acting on
  • Low potassium Worth acting on
  • Heart failure Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • Liver problems Worth acting on

Showing the 10 most notable of 26 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cobimetinib Fumarate. Read the label on DailyMed › Smartweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Smartweed side to compare — that is a limit of the record, not a statement that Smartweed has no side effects.

From our Q&A

Questions About Smartweed or Cobimetinib Fumarate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Smartweed or Cobimetinib Fumarate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cobimetinib Fumarate

This page covers Smartweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobimetinib Fumarate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Cobimetinib Fumarate page

“If you are on cobimetinib (Cotellic) for melanoma, be strict about supplements, because this list carries real weight. The drug is cleared by the liver enzyme CYP3A4, and nearly all 138 flagged ingredients can push its blood level up or down through that pathway.”

Reviewed by 2 · Jul 18, 2026

Open the Cobimetinib Fumarate interaction page

One more smart check

Taking Smartweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Smartweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Smartweed. Even though Smartweed itself has no known interaction with Cobimetinib Fumarate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Smartweed and Cobimetinib Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Smartweed
Top half

#644 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cobimetinib Fumarate
Steady interest

#2,101 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Smartweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Smartweed and Cobimetinib Fumarate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Smartweed

What is Smartweed?

Smartweed
  • Digestive upset
  • Minor skin irritation
  • Heavy menstrual bleeding (traditional)
  • Wound and bleeding (traditional topical use)
  • Antioxidant and anti-inflammatory support

Smartweed (Persicaria hydropiper) is a peppery wetland plant with a long history in traditional medicine for digestive complaints, bleeding, and skin problems. Modern human studies are very limited, so its benefits are not well proven. Because safety data are thin, it's best to use cautiously and avoid it during pregnancy and breastfeeding.

Persicaria hydropiper · Polygonaceae · Aerial parts (leaves, stems, and flowering tops); sometimes the whole plant · Tea, tincture, liquid extract, dried herb, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Smartweed is a good idea for someone in your situation. Here is what our Smartweed record says about it on its own.

Smartweed: dosing

There is no well-established or standardized dose for smartweed. Because it has not been carefully studied in people, experts cannot recommend a safe and effective amount.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Smartweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Smartweed monograph & all interactions
Medication

About Cobimetinib

What Is Cobimetinib Used For?

Brand name: Cotellic

Cobimetinib is approved for two uses in adults. First, it is used in combination with another drug called vemurafenib to treat melanoma (a type of skin cancer) that cannot be surgically removed or has spread to other parts of the body — but only when the tumor carries a specific genetic change called a BRAF V600E or V600K mutation. A lab test must confirm this mutation before treatment begins.

Second, cobimetinib can be used on its own (as a single agent) to treat adults with histiocytic neoplasms — a rare group of cancers involving immune cells called histiocytes.

See full Cobimetinib drug information
Keep checking

Other Drugs & Smartweed

Browse every other medication we’ve checked against Smartweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Smartweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Smartweed list.

See the full Smartweed interactions page
See every supplement checked against Cobimetinib Fumarate, ranked by severity
Evidence & sources

Smartweed References

The 2 references that drive our Smartweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Smartweed and Cobimetinib Fumarate Together: Common Questions

Is it safe to take Smartweed with Cobimetinib Fumarate?
We do not list a known interaction between Smartweed and Cobimetinib Fumarate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Smartweed and Cobimetinib Fumarate combination checked?
Interactions in our licensed database are recorded against drug classes. Cobimetinib Fumarate is filed under 2 classifications, and Smartweed has documented interactions with 1 drug class — none of Cobimetinib Fumarate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Smartweed interact with any other medications?
Yes. Smartweed has 2 documented drug interactions in our database — Cobimetinib Fumarate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cobimetinib Fumarate interact with any supplements?
Yes. Cobimetinib Fumarate has documented interactions with 138 supplements in our database — Smartweed is not one of them. The Cobimetinib Fumarate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Smartweed monograph Uses, safety profile, and every drug interaction in one place Cobimetinib drug information The full plain-English guide to this medication Cobimetinib Fumarate supplement interactions Every supplement checked against Cobimetinib Fumarate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cobimetinib Fumarate and Smartweed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.