Drug & supplement interaction

Sodium Tetrachloroaurate + Trametinib

Trametinib brand name: Mekinist.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sodium Tetrachloroaurate and Trametinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Trametinib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sodium Tetrachloroaurate and Trametinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trametinib and Sodium Tetrachloroaurate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sodium Tetrachloroaurate at all — not against Trametinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sodium Tetrachloroaurate safety at a glance

Sodium Tetrachloro... overall Avoid This is an industrial gold(III) salt, not a supplement, and is not safe to consume.
Pregnancy Possibly Unsafe When used orally or parenterally. Sodium tetrachloroaurate is a gold salt. Evidence from animal models shows that the administration of other gold salts increas... Read the full pregnancy detail
Breastfeeding Avoid Not for human use; avoid entirely while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trametinib and Sodium Tetrachloroaurate? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Sodium Tetrachloroaurate and Trametinib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • A low platelet count / Anemia / A low white blood cell count Worth acting on Additional detail

    Sodium Tetrachloroaurate

    “No adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted. Sodium tetrachloroaurate contains gold and might cause adverse effects similar to other gold salts. Orally, gold salts have been reported to cause gastrointestinal side effects, including diarrhea, loose stools, nausea, vomiting, and abdominal cramps.”

    Sodium Tetrachloroaurate · Natural Medicines adverse-effect record, reported in anemia.

    3 sources cited
    1. 100534. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.
    2. 100535. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Gold Preparations. [Updated 2017 Aug 2].
    3. 100536. Eisler R. Chrysotherapy: a synoptic review. Inflamm Res. 2003;52(12):487-501. PubMed

    “Orally or parenterally, gold salts may cause gold toxicity, with signs including immune thrombocytopenia, leukopenia, granulocytopenia, and aplastic anemia. Sodium tetrachloroaurate is a gold salt and may theoretically cause similar adverse effects.”

    Sodium Tetrachloroaurate · Natural Medicines adverse-effect record, reported in anemia.

    1 source cited
    1. 100534. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.

    Trametinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Trametinib. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    Sodium Tetrachloroaurate

    “Orally and parenterally, gold salts may cause nephrotic syndrome with proteinuria and hematuria. These adverse effects are typically mild, but may become severe and chronic if treatment is not discontinued after onset of the reaction. Sodium tetrachloroaurate is a gold salt and may theoretically cause similar adverse effects.”

    Sodium Tetrachloroaurate · Natural Medicines adverse-effect record, reported in nephrotic syndrome.

    1 source cited
    1. 100534. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.

    Trametinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Trametinib. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Sodium Tetrachloroaurate

    “Orally and parenterally, gold salts have been associated with slight elevations in serum aminotransferase levels. Parenterally, gold salts have also been associated with acute liver injury, although this is less common. Onset of injury seems to occur 1-8 weeks after starting therapy. Initial symptoms of liver injury include fever, rash, malaise, nausea, dark urine, and jaundice.”

    Sodium Tetrachloroaurate · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 100535. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Gold Preparations. [Updated 2017 Aug 2].

    Trametinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Trametinib. Read the label on DailyMed ›

  • Fever / Tiredness reported in 16.9% of FDA reports for Trametinib Additional detail

    Sodium Tetrachloroaurate

    Recorded for Sodium Tetrachloroaurate in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Trametinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Trametinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A change in taste / Mouth irritation or sores Additional detail

    Sodium Tetrachloroaurate

    “Orally, gold salts can cause stomatitis, which may be preceded by a metallic taste. Other adverse events including diarrhea, loose stools, nausea, vomiting, and abdominal cramps may also occur. Ulcerative enterocolitis has also been reported, but this is rare. Sodium tetrachloroaurate is a gold salt and may theoretically cause similar adverse effects.”

    Sodium Tetrachloroaurate · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 100534. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.

    Trametinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Trametinib. Read the label on DailyMed ›

  • Itching Additional detail

    Sodium Tetrachloroaurate

    “Parenterally, gold salts commonly cause cutaneous reactions including pruritus and dermatitis. Chrysiasis, which is an irreversible blue-gray discoloration of the skin, may also occur. Exposure to sunlight might worsen these reactions. Sodium tetrachloroaurate is a gold salt and may theoretically cause similar adverse effects.”

    Sodium Tetrachloroaurate · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 100534. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.

    Trametinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Trametinib. Read the label on DailyMed ›

Showing the 10 most notable of 15 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Sodium Tetrachloroaurate but not commonly for Trametinib: liver problems and yellowing of the skin or eyes.

Effects for Trametinib come from the ADVERSE REACTIONS section of its FDA label; effects for Sodium Tetrachloroaurate come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 23,697 voluntary FDA FAERS reports for Trametinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Sodium Tetrachloroaurate in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally or parenterally. Sodium tetrachloroaurate is a gold salt. Evidence from animal models shows that the administration of other gold salts increases the risk of miscarriage and congenital abnormalities in the offspring. Theoretically, sodium tetrachloroaurate may have similar adverse effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Trametinib Products Have a Food Rule — Sodium Tetrachloroaurate Should Not Break It

At least one FDA label for a product containing Trametinib says to take it on an empty stomach. Most supplements — Sodium Tetrachloroaurate included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Trametinib on its own and move Sodium Tetrachloroaurate to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Trametinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

MEKINIST Tablets Take MEKINIST tablets on an empty stomach (at least 1 hour before or 2 hours after a meal) [see Clinical Pharmacology (12.3)] .

From the Dosage and Administration section of the FDA label we read for Trametinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Trametinib

This page covers Sodium Tetrachloroaurate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trametinib page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Trametinib interaction page

One more smart check

Taking Sodium Tetrachloroaurate as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Sodium Tetrachloroaurate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sodium Tetrachloroaurate. Even though Sodium Tetrachloroaurate itself has no known interaction with Trametinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sodium Tetrachloroaurate and Trametinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sodium Tetrachloroaurate
Steady interest

#1,017 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trametinib
Top 25%

#350 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sodium Tetrachloroaurate reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sodium Tetrachloroaurate and Trametinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sodium Tetrachloroaurate

What is Sodium Tetrachloroaurate?

  • Used in chemistry as a source of gold
  • Gold nanoparticle synthesis (research)
  • Electroplating and gold chemistry
  • Marketed by some sellers as a 'colloidal gold' precursor

Sodium tetrachloroaurate is a gold(III) chemical compound used in laboratories and industry, not a dietary supplement or herb. It is not approved or recommended for human use, and ingesting it can be harmful. Do not take it as a supplement.

Not a plant; this is a chemical gold(III) compound · Laboratory reagent solution; not sold as a dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Sodium Tetrachloroaurate is a good idea for someone in your situation. Here is what our Sodium Tetrachloroaurate record says about it on its own.

Sodium Tetrachloroaurate: dosing

There is no established or safe human dose for sodium tetrachloroaurate, because it is not a dietary supplement or approved medicine. We cannot and will not provide an amount to take.Do not consume this product.

From our Sodium Tetrachloroaurate monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sodium Tetrachloroaurate monograph & all interactions
Medication

About Trametinib

What Is Trametinib Used For?

Brand name: Mekinist

Mekinist is used to treat cancers that have a BRAF V600E or V600K mutation — a specific genetic change that tells cancer cells to grow out of control. It can be used alone or, more often, paired with another targeted medicine called dabrafenib.

On its own, Mekinist treats certain patients with unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) melanoma who have not previously received a BRAF inhibitor. In combination with dabrafenib, Mekinist is used for metastatic or surgically treated melanoma, metastatic non-small cell lung cancer (NSCLC), locally advanced or metastatic anaplastic thyroid cancer (ATC), certain other BRAF V600E-positive solid tumors in adults and children 1 year and older, and low-grade glioma (a type of brain tumor) in children 1 year and older. A BRAF mutation must be confirmed by an FDA-approved test before starting treatment.

Most-Reported Side Effects for Trametinib

From FAERS, the FDA’s public side-effect reporting system (24,023 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 4,068 reports
Malignant neoplasm progression 2,040 reports
Rash 1,736 reports
Fatigue 1,516 reports
Nausea 1,496 reports
See full Trametinib drug information
Keep checking

Other Drugs & Sodium Tetrachloroaurate

Browse every other medication we’ve checked against Sodium Tetrachloroaurate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sodium Tetrachloroaurate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sodium Tetrachloroaurate list.

See the full Sodium Tetrachloroaurate interactions page
See every supplement checked against Trametinib, ranked by severity
Evidence & sources

Sodium Tetrachloroaurate References

The 3 references that drive our Sodium Tetrachloroaurate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.
  2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Gold Preparations. [Updated 2017 Aug 2].
  3. Eisler R. Chrysotherapy: a synoptic review. Inflamm Res. 2003;52(12):487-501. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sodium Tetrachloroaurate and Trametinib Together: Common Questions

Is it safe to take Sodium Tetrachloroaurate with Trametinib?
We do not list a known interaction between Sodium Tetrachloroaurate and Trametinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sodium Tetrachloroaurate and Trametinib have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Sodium Tetrachloroaurate and Trametinib at the same time of day?
At least one FDA label for a product containing Trametinib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Trametinib on its own and move Sodium Tetrachloroaurate to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Trametinib interact with any supplements?
Yes. Trametinib has documented interactions with 17 supplements in our database — Sodium Tetrachloroaurate is not one of them. The Trametinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sodium Tetrachloroaurate monograph Uses, safety profile, and every drug interaction in one place Trametinib drug information The full plain-English guide to this medication Trametinib supplement interactions Every supplement checked against Trametinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trametinib and Sodium Tetrachloroaurate?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.